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may play a role in bone homeostasis.
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Results indicate an association of MEPE gene inactivation with decreased survival after DNA damage.
Mice deficient in an ortholog of MEPE show increased bone mass and are resistant to aging-related bone loss.
results indicated that MEPE appeared to play an important positive role in proliferation and osteogenesis differentiation of DPCs through interaction with downstream signals.
MEPE or the MEPE-derived acidic serine aspartate-rich MEPE-associated motif peptide may contribute to decreased bone mineralization in Oncogenic osteomalacia patients.
Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke.
Sclerostin (zeige SOST ELISA Kits) acts through regulation of the PHEX (zeige PHEX ELISA Kits)/MEPE axis at the preosteocyte stage and serves as a master regulator of physiologic bone mineralization.
MEPE may play a regulatory role in periodontal ligament cell osteogenic differentiation.
These results suggest that abnormal MEPE cleavage occurs when PHEX (zeige PHEX ELISA Kits) activity is deficient in humans.
This study demonstrates the importance of posttranslational modification for the site-specific activity of MEPE and its ASARM peptide.
The patterns of expression of FGF-23 (zeige FGF23 ELISA Kits), MEPE, and DMP1 (zeige DMP1 ELISA Kits) differ markedly in trabecular bone, suggesting that individual osteocytes may have specialized functions.
Mepe(-/-) molars exhibited increased thickness of predentin, dentin, and enamel over controls and decreased gene expression of Enam (zeige ENAM ELISA Kits), Bsp (zeige KLK6 ELISA Kits), Dmp1 (zeige DMP1 ELISA Kits), Dspp (zeige DSPP ELISA Kits), and Opn (zeige SPP1 ELISA Kits) by RT-PCR.
An in situ hybridization study of perlecan (zeige HSPG2 ELISA Kits), DMP1 (zeige DMP1 ELISA Kits), and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.
MEPE is an important regulator of growth plate chondrocyte matrix mineralization through its cleavage to an ASARM peptide.
The temporal-spatial specific pattern and unique co-localization of Dspp (zeige DSPP ELISA Kits), Mepe, Mimecan (zeige OGN ELISA Kits) and Versican (zeige Vcan ELISA Kits) suggest they play complementary roles during odontogenesis.
Wnt3a (zeige WNT3A ELISA Kits) stimulates Mepe transcription directly by a canonical Wnt (zeige WNT2 ELISA Kits) signaling pathway through beta-catenin (zeige CTNNB1 ELISA Kits) and Lef-1 (zeige LEF1 ELISA Kits) and indirectly through the activation of a Bmp-2 (zeige BMP2 ELISA Kits) autocrine loop.
MEPE might be an important signaling molecule involved in the regulation of osteoblast and osteoclast activity during bone remodeling.
the C-terminal fragment of MEPE containing an RGD sequence, cleaved in odontoblasts, appeared to be the active form of MEPE, which may play important roles in dentinogenesis and pulpal homeostasis by keeping the odontoblasts in immature condition.
MEPE may be involved in the pathogenesis defective mineralization due to Phex (zeige PHEX ELISA Kits) deficiency in X-linked hypophosphatemia (XLH (zeige PHEX ELISA Kits)) and the Hyp (zeige PHEX ELISA Kits)-mouse.
Mepe appears to play a role in both long bone regeneration and the latter stages of skeletogenesis.
degradation of MEPE and DMP-1 (zeige DMP1 ELISA Kits) and release of ASARM peptides are chiefly responsible for the HYP (zeige PHEX ELISA Kits) mineralization defect and changes in osteoblast-osteoclast differentiation.
may play a role in bone homeostasis
matrix extracellular phosphoglycoprotein
, matrix, extracellular phosphoglycoprotein with ASARM motif (bone)
, matrix, extracellular phosphoglycoprotein with ASARM motif (bone)-like
, matrix extracellular phosphoglycoprotein-like
, osteoblast/osteocyte factor 45
, matrix extracellular phosphoglycoprotein with ASARM motif (bone)
, ovocleidin-116 protein
, matrix extracellular phosphoglycoprotein with ASARM motif