Maternal Embryonic Leucine Zipper Kinase Proteine (MELK)

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Zusätzlich bieten wir Ihnen MELK Antikörper (136) und MELK Kits (25) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MELK 9833 Q14680
MELK 17279 Q61846
MELK 362510  
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Top MELK Proteine auf antikoerper-online.de

Showing 10 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Insektenzellen Human Unkonjugiert 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$1,502.67
Details
Escherichia coli (E. coli) Human GST tag 5 μg Anmelden zum Anzeigen 11 bis 12 Tage
$516.00
Details
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details
Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$363.67
Details

MELK Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartnern

Human Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. data suggest that MELK is a modulator of tumor cell growth and survival in a hypoxic microenvironment in adrenal cancer cells and support future investigation of its role as a therapeutic kinase target in patients with Adrenocortical Carcinoma.

  2. Study found that STRAP and MELK were overexpressed and highly phosphorylated in samples form colorectal adenocarcinoma patients and their expression were significantly correlated with tumor stages.

  3. Study demonstrates that the interaction occurring between MELK and EZH2 promotes self-proliferation and stemness.

  4. In common culture conditions, the authors found that small molecule inhibition, genetic deletion, or acute depletion of MELK did not significantly affect cellular growth.

  5. Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling.

  6. Inhibition of MELK (genetically and pharmacologically) induces radiation sensitivity.

  7. MELK is a host factor required for optimal uncoating of the HIV-1 core to promote viral cDNA synthesis.

  8. Here, the authors report that mutagenizing MELK with CRISPR/Cas9 has no effect on the fitness of basal breast cancer cell lines or cell lines from six other cancer types. Cells that harbor null mutations in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent growth.

  9. MELK-inhibitor has a role in triple-negative breast cancer cells demonstrating context-dependent response with p53 as a key determinant

  10. MELK is an oncogenic kinase involved in the pathogenesis and recurrence of hepatocellular carcinoma.

  11. Inhibition or depletion of MELK reduced cell proliferation and anchorage-dependent and -independent growth in various ovarian cancer cell lines through a G2/M cell cycle arrest, eventually resulting in apoptosis.

  12. Report IL11RA and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas.

  13. MELK expression in hepatocellular carcinoma is extremely intense compared to its expression reported in other types of cancer and could be a promising effective tumor marker of HCC.

  14. targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold

  15. Together, these data indicate that MELK is a normally non-essential kinase, but is critical for basal-like breast cancer.

  16. EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner

  17. we report characterization of possible roles of MELK in acute myeloid leukemia

  18. insight has been brought by the discovery of a protein complex of FOXM1 with the mitotic kinase MELK in cancer stem cells in brain cancers, as this protein complex appears to be cancer-specific

  19. advanced cancers with OTSSP167 started in 2013, as the first-in-class MELK inhibitor. This review summarizes the current molecular understanding of MELK and the recent preclinical studies about MELK as a cancer therapeutic target.

  20. MELK promotes cell migration and invasion via the FAK/Paxillin pathway, and plays an important role in the occurrence and development of gastric cancer.

Mouse (Murine) Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. MELK promotes cell migration and invasion via the FAK/Paxillin pathway, and plays an important role in the occurrence and development of gastric cancer.

  2. Phosphorylation of the activation loop of MPK38 induces its movement resulting in kinase activation.

  3. These results indicate that Trx functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1-, TGF-beta, and p53-mediated activity

  4. an important role for MPK38-mediated phosphorylation of PDK1 in the negative regulation of PDK1 activity.

  5. MPK38 may act as a novel regulator for promoting p53 activity through direct phosphorylation of p53 at Ser(15).

  6. Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.

  7. MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain.

  8. The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported.

  9. MPK38 physically interacts with ASK1 in vivo and acts as a positive upstream regulator of ASK1

Zebrafish Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.

Xenopus laevis Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. Overexpression of xMELK leads to failure of cytokinesis and impairs accumulation RhoA- a pivotal regulator of cytokinesis.

  2. These results demonstrate the presence of a mitochondrial targeting signal at the N-terminus of the MC domain of MELK. This mitochondrial targeting signal was also functional in human HeLa cells.[MELK]

MELK Protein Überblick

Protein Überblick

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.

Genbezeichner und Symbole assoziert mit MELK

  • maternal embryonic leucine zipper kinase (MELK)
  • maternal embryonic leucine zipper kinase (melk)
  • maternal embryonic leucine zipper kinase (cgd5_2270)
  • maternal embryonic leucine zipper kinase (Melk)
  • maternal embryonic leucine zipper kinase L homeolog (melk.L)
  • AI327312 Protein
  • fb71b01 Protein
  • fe01f04 Protein
  • HPK38 Protein
  • Melk Protein
  • mKIAA0175 Protein
  • MPK38 Protein
  • wu:fb71b01 Protein
  • wu:fe01f04 Protein
  • xmelk Protein

Bezeichner auf Proteinebene für MELK

maternal embryonic leucine zipper kinase , maternal embryonic leucine zipper kinase-like , pEg3 kinase , protein kinase Eg3 , protein kinase PK38 , tyrosine-protein kinase MELK , zMelk , Protein kinase Eg3

GENE ID SPEZIES
428391 Gallus gallus
465095 Pan troglodytes
549144 Xenopus (Silurana) tropicalis
3373320 Cryptosporidium parvum Iowa II
100123808 Nasonia vitripennis
100386947 Callithrix jacchus
100586707 Nomascus leucogenys
9833 Homo sapiens
481608 Canis lupus familiaris
520088 Bos taurus
17279 Mus musculus
362510 Rattus norvegicus
30724 Danio rerio
397927 Xenopus laevis
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