anti-Maternal Embryonic Leucine Zipper Kinase (MELK) Antikörper

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Zusätzlich bieten wir Ihnen MELK Kits (25) und MELK Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MELK 9833 Q14680
MELK 17279 Q61846
MELK 362510  
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Top anti-MELK Antikörper auf antikoerper-online.de

Showing 10 out of 154 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-MELK Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HT1080 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host:  Rabbit  Target Name:  Melk  Sample Type:  Mouse Testis lysates  Antibody Dilution:  1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, WB ABIN184576 (0.1µg/ml) staining of human testes lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Maus Unkonjugiert ICC, FACS, IHC, ELISA Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of MCF-7 cells using MELK mouse mAb (green) and negative control (red) . 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$430.10
Details
Human Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of MELK staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of MELK staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Maus Unkonjugiert ELISA, FACS, ICC, IHC Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Immunohistochemical analysis of paraffin-embedded liver cancer tissues using MELK mouse mAb with DAB staining.  Dilution: 1/200 - 1/1000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$561.00
Details
Human Maus Unkonjugiert ELISA, FACS, IF/ICC, IHC 100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details
Human Maus Unkonjugiert ELISA, FACS, IF, IHC 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from K562 cells, using MELK Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert CyTOF, ELISA, FACS, ICC, IF, IHC ELISA: MELK Antibody (2G2) [NBP2-37481] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng); Immunohistochemistry: MELK Antibody (2G2) [NBP2-37481] - Immunohistochemical analysis of paraffin-embedded liver cancer tissues using MELK mouse mAb with DAB staining. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details

MELK Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-MELK Antikörper

  1. Human Monoclonal MELK Primary Antibody für ICC, FACS - ABIN969538 : Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. in Neuro-oncology 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal MELK Primary Antibody für WB - ABIN2475560 : Nagase, Seki, Ishikawa, Tanaka, Nomura: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. in DNA research : an international journal for rapid publication of reports on genes and genomes 1996 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MELK Primary Antibody für - ABIN2017585 : Hu, Ru, Xiao, Chaturbedi, Hoa, Tian, Zhang, Ke, Yan, Nelson, Li, Gramer, Yu, Siegel, Zhang, Jia, Jadus, Limoli, Linskey, Xing, Zhou: Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. in PLoS ONE 2013 (PubMed)

Weitere Antikörper gegen MELK Interaktionspartner

Human Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. Study demonstrates that the interaction occurring between MELK and EZH2 (zeige EZH2 Antikörper) promotes self-proliferation and stemness.

  2. In common culture conditions, the authors found that small molecule inhibition, genetic deletion, or acute depletion of MELK did not significantly affect cellular growth.

  3. Synthesis of MCL1 (zeige MCL1 Antikörper), an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling.

  4. Inhibition of MELK (genetically and pharmacologically) induces radiation sensitivity.

  5. MELK is a host factor required for optimal uncoating of the HIV-1 core to promote viral cDNA synthesis.

  6. Here, the authors report that mutagenizing MELK with CRISPR/Cas9 has no effect on the fitness of basal breast cancer cell lines or cell lines from six other cancer types. Cells that harbor null mutations in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent growth.

  7. MELK-inhibitor has a role in triple-negative breast cancer cells demonstrating context-dependent response with p53 (zeige TP53 Antikörper) as a key determinant

  8. MELK is an oncogenic kinase involved in the pathogenesis and recurrence of hepatocellular carcinoma.

  9. Inhibition or depletion of MELK reduced cell proliferation and anchorage-dependent and -independent growth in various ovarian cancer cell lines through a G2/M cell cycle arrest, eventually resulting in apoptosis.

  10. Report IL11RA (zeige IL11RA Antikörper) and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas.

Mouse (Murine) Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. MELK promotes cell migration and invasion via the FAK (zeige PTK2 Antikörper)/Paxillin (zeige PXN Antikörper) pathway, and plays an important role in the occurrence and development of gastric cancer.

  2. Phosphorylation of the activation loop of MPK38 induces its movement resulting in kinase activation.

  3. These results indicate that Trx (zeige TXN Antikörper) functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1 (zeige MAP3K5 Antikörper)-, TGF-beta (zeige TGFB1 Antikörper), and p53 (zeige TP53 Antikörper)-mediated activity

  4. an important role for MPK38-mediated phosphorylation of PDK1 (zeige PDPK1 Antikörper) in the negative regulation of PDK1 (zeige PDPK1 Antikörper) activity.

  5. MPK38 may act as a novel regulator for promoting p53 (zeige TP53 Antikörper) activity through direct phosphorylation of p53 (zeige TP53 Antikörper) at Ser (zeige SIGLEC1 Antikörper)(15).

  6. Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.

  7. MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP (zeige GFAP Antikörper)-expressing progenitors to rapid amplifying progenitors in the postnatal brain.

  8. The characterization of two novel E2F (zeige E2F1 Antikörper) target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1 (zeige NCAPD2 Antikörper)) and maternal embryonic leucine zipper kinase (Melk) is reported.

  9. MPK38 physically interacts with ASK1 (zeige MAP3K5 Antikörper) in vivo and acts as a positive upstream regulator of ASK1 (zeige MAP3K5 Antikörper)

Zebrafish Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.

Xenopus laevis Maternal Embryonic Leucine Zipper Kinase (MELK) Interaktionspartner

  1. Overexpression of xMELK leads to failure of cytokinesis and impairs accumulation RhoA- a pivotal regulator of cytokinesis.

  2. These results demonstrate the presence of a mitochondrial targeting signal at the N-terminus of the MC domain of MELK. This mitochondrial targeting signal was also functional in human HeLa cells.[MELK]

MELK Antigen-Profil

Protein Überblick

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.

Genbezeichner und Symbole assoziert mit MELK

  • maternal embryonic leucine zipper kinase (MELK) Antikörper
  • maternal embryonic leucine zipper kinase (melk) Antikörper
  • maternal embryonic leucine zipper kinase (cgd5_2270) Antikörper
  • maternal embryonic leucine zipper kinase (Melk) Antikörper
  • maternal embryonic leucine zipper kinase L homeolog (melk.L) Antikörper
  • AI327312 Antikörper
  • fb71b01 Antikörper
  • fe01f04 Antikörper
  • HPK38 Antikörper
  • Melk Antikörper
  • mKIAA0175 Antikörper
  • MPK38 Antikörper
  • wu:fb71b01 Antikörper
  • wu:fe01f04 Antikörper
  • xmelk Antikörper

Bezeichner auf Proteinebene für MELK

maternal embryonic leucine zipper kinase , maternal embryonic leucine zipper kinase-like , pEg3 kinase , protein kinase Eg3 , protein kinase PK38 , tyrosine-protein kinase MELK , zMelk , Protein kinase Eg3

GENE ID SPEZIES
428391 Gallus gallus
465095 Pan troglodytes
549144 Xenopus (Silurana) tropicalis
3373320 Cryptosporidium parvum Iowa II
100123808 Nasonia vitripennis
100386947 Callithrix jacchus
100586707 Nomascus leucogenys
9833 Homo sapiens
481608 Canis lupus familiaris
520088 Bos taurus
17279 Mus musculus
362510 Rattus norvegicus
30724 Danio rerio
397927 Xenopus laevis
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