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MAN1B1 encodes an enzyme belonging to the glycosyl hydrolase 47 family. Zusätzlich bieten wir Ihnen MAN1B1 Antikörper (21) und viele weitere Produktgruppen zu diesem Protein an.
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Results show that MAN1B1 expression was higher in bladder cancer (BC) tissues than those in normal tissues. Its overexpression was associated with poor prognosis. Furthermore, MAN1B1 seems to act as an oncogene (zeige RAB1A Proteine) in BC, which improved the likelihood of MAN1B1 taking on a promising prognostic biomarker.
The two genetic associations with severe liver disease that had been suspected previously (one SNP for SERPINA1 (zeige SERPINA1 Proteine) and another for MAN1B1) were not confirmed in our cohort. For MAN1B1, four major haplotypes were identified but the prevalence of PHT did not significantly differ between them.
in the bound substrate complex, hydrophobic stacking interactions between Trp (zeige TBPL1 Proteine) residues and the glycan core anchor the base of the glycan structure to the enzyme cleft
MAN1B1 defective congenital disorder of glycosylation is reviewed.
Data show that HIV-1 env (zeige ERVW-1 Proteine) protein interacts with alpha-mannosidases ERManI (MAN1B1) and initiates endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway degradation process.
The properties of ERMAN1 enable rapid selection of endoplasmic reticulum-associated degradation substrates in the endoplasmic reticulum.ERMAN1 digests mono-, di- and tri (zeige VANGL2 Proteine)-glucosylated N-glycans.
we linked mutations in MAN1B1 to a Golgi glycosylation disorder. Additionally, our results support the recent findings on MAN1B1 localization
MAN1B1 deficiency appeared to be a frequent cause in our cohort of patients with unsolved congenital disorder of glycosylation type II.
A novel post-transcriptional regulatory mechanism for ERManI via miR (zeige MLXIP Proteine)-125b and this molecule contributes to the regulation of carcinogenesis in hepatocellular carcinoma.
ERManI and gamma-COP contribute to a golgi-based quality control module that facilitates the retrieval of captured ERAD substrates back to the endoplasmic reticulum.
This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.
mannosidase, alpha, class 1B, member 1
, alpha 1,2-mannosidase
, ER alpha 1,2-mannosidase
, Man9GlcNAc2-specific processing alpha-mannosidase
, endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
, endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1
, ER alpha-1,2-mannosidase
, ER mannosidase 1
, man9GlcNAc2-specific-processing alpha-mannosidase