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The protein encoded by MCTS1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Zusätzlich bieten wir Ihnen Malignant T Cell Amplified Sequence 1 Proteine (10) und Malignant T Cell Amplified Sequence 1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Polyclonal MCTS1 Primary Antibody für IHC - ABIN966547
Carpenter, Poole, Halestrap: Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. in Biochimica et biophysica acta 1996
Show all 6 Pubmed References
Human Polyclonal MCTS1 Primary Antibody für WB - ABIN152954
Kumar, Kant, Singh et al.: Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage ... in Toxicology and applied pharmacology 2013
Human Polyclonal MCTS1 Primary Antibody für WB - ABIN4891880
Haas, Ngo, Li, Schleich, Qu, Vanyai, Cullen, Cardona-Alberich, Gladwyn-Ng, Pagnamenta, Taylor, Stewart, Kini, Duncan, Teleman, Keays, Heng: De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation. in Cell reports 2016
Hypoxia-induced MCT1 (zeige CMA1 Antikörper) supports glioblastoma glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness
our finding that the expression of MCT1 (zeige CMA1 Antikörper) and MCT4 (zeige SLC16A4 Antikörper) is reduced in mutant IDH1 (zeige IDH1 Antikörper) gliomas highlights the unusual metabolic reprogramming that occurs in mutant IDH1 (zeige IDH1 Antikörper) tumors and has important implications for our understanding of these tumors and their treatment
DENR (zeige DENR Antikörper) binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1 (zeige EIF1 Antikörper)/eIF2 (zeige EIF2S1 Antikörper)/eIF3 (zeige EIF3A Antikörper) binding, thus operating in post-termination ribosome recycling and translation re-initiation
MCT1 (zeige CMA1 Antikörper) expression, independent of transporter activity, is required for growth factor-induced tumor cell motility.
TOMM20 (zeige TOMM20 Antikörper), MCT1 (zeige CMA1 Antikörper), and MCT4 (zeige SLC16A4 Antikörper) expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of MCT1 (zeige CMA1 Antikörper), while tumor associated macrophages have absent MCT1 (zeige CMA1 Antikörper) expression. Tumor-infiltrating lymphocytes have absent MCT1 (zeige CMA1 Antikörper) expression. Reactive lymph nodes in contrast to cHL (zeige CHRDL1 Antikörper) tumors had low TOMM20 (zeige TOMM20 Antikörper), MCT1 (zeige CMA1 Antikörper), and MCT4 (zeige SLC16A4 Antikörper) expression in lymphocytes and macrophages.
TOMM20 (zeige TOMM20 Antikörper) and MCT1 (zeige CMA1 Antikörper) were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers.
MCT1 (zeige CMA1 Antikörper) inhibitor AZD3965 increased MCT4 (zeige SLC16A4 Antikörper)-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.
Silencing or genetic deletion of MCT1 (zeige CMA1 Antikörper) in vivo inhibited migration, invasion, and spontaneous metastasis.
The reversible H(+)/lactate(-) symporter MCT1 (zeige CMA1 Antikörper) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.
Reinitiation complexes involving initiation factors eIF2D (zeige EIF2D Antikörper), MCT-1 (zeige CMA1 Antikörper), and DENR (zeige DENR Antikörper) controls the translation of a large fraction of mammalian cellular mRNAs.
This study confirmed age-dependent changes of MCT1 expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 increases with the development of rumen function and also in adult animals MCT 1 may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
Data suggest that expression of MCT1 in intestinal mucosa can be altered by diet; here, expression of MCT1 is down-regulated in colonic mucosa by high-protein diet and appears to be linked to fermentation of dietary proteins by intestinal microbes.
MCT1-mRNA showed a higher expression in the ileum; feeding inulin-coated butyrate resulted in an increased ileal surface; delivery of butyrate to the colon requires a more resistant inulin-coating.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
malignant T cell-amplified sequence 1
, malignant T-cell-amplified sequence 1
, multiple copies T-cell malignancies
, MCT 1
, monocarboxylate transporter 1
, solute carrier family 16 (monocarboxylic acid transporters), member 1
, solute carrier family 16 member 1
, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
, multiple copies T-cell malignancies 1
, malignant T cell amplified sequence 1
, Malignant T cell amplified sequence 1-A
, malignant T cell-amplified sequence 1-A
, malignant T-cell-amplified sequence 1-A