anti-MKL/myocardin-Like 2 (MKL2) Antikörper

Acts as a transcriptional coactivator of serum response factor (SRF). Zusätzlich bieten wir Ihnen MKL2 Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MKL2 57496 Q9ULH7
MKL2 100362470  
MKL2 239719 P59759
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Top anti-MKL2 Antikörper auf antikoerper-online.de

Showing 10 out of 30 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of MKL2 Antibody (N-term) in mouse bladder tissue lysates (35ug/lane). This demonstrates the MKL2 antibody detected the MKL2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of MKL2 expression in HEK293T (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Maus Kaninchen Unkonjugiert WB MKL2 Antibody (N-term) (ABIN656903) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the MKL2 antibody detected the MKL2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: MKL2 Antibody [NBP1-46209] - Sample: FFPE section of human prostate carcinoma and linitis plastica stomach cancer . Antibody: Affinity purified rabbit anti-MKL2 used at a dilution of 1:200 (1ug/ml) and 1:1,000 (0.2ug/ml). Detection: DAB Western Blot: MKL2 Antibody [NBP1-46209] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug), and mouse NIH3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-MKL2 antibody NBP1-46209 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. MKL2 was also immunoprecipitated by rabbit anti-MKL2 antibody NBP1-46208, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 10 seconds (A and B). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert IP Immunoprecipitation: MKL2 Antibody [NBP1-46208] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Affinity purified rabbit anti-MKL2 antibody used for IP at 3 mcg/mg lysate. MKL2 was also immunoprecipitated by rabbit anti-MKL2 antibody NBP1-46209, which recognizes a downstream epitope. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$375.83
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$581.17
Details
Rind (Kuh) Kaninchen Unkonjugiert IF, IP, IHC (p), WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$595.83
Details
Human Kaninchen Unkonjugiert ELISA, WB   200 μL Anmelden zum Anzeigen 7 bis 9 Tage
$793.83
Details
Maus Kaninchen Alkaline Phosphatase (AP) ELISA, WB   200 μL Anmelden zum Anzeigen 7 bis 9 Tage
$1,013.83
Details

MKL2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human ,
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Rat (Rattus)


Mouse (Murine)


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Weitere Antikörper gegen MKL2 Interaktionspartner

Human MKL/myocardin-Like 2 (MKL2) Interaktionspartner

  1. Study showed that MRTF-A (zeige MKL1 Antikörper) and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.

  2. While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development.

  3. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2 (zeige BACH2 Antikörper); many of these integrations were in clonally expanded cells.

  4. MKL1 (zeige MKL1 Antikörper)/2 depletion resulted in Ras activation, elevated p16 (zeige CDKN2A Antikörper) expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1 (zeige DYNLL1 Antikörper)-deficient hepatocellular carcinoma cells.

  5. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.

  6. study provides evidence that MKL1 (zeige MKL1 Antikörper)/2 mediates cancerous transformation in DLC1 (zeige DYNLL1 Antikörper)-deficient hepatocellular and mammary carcinoma cells

  7. C11orf95-MKL2 is the resulting fusion oncogene (zeige RAB1A Antikörper) of t(11;16)(q13;p13) in chondroid lipoma.

  8. dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro.

  9. BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases.

  10. Myocardin (zeige MYOCD Antikörper)-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[

Mouse (Murine) MKL/myocardin-Like 2 (MKL2) Interaktionspartner

  1. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  2. MRTF-A (zeige MKL1 Antikörper)/B depletion results in an increase in the cell surface expression of ICAM-1 (zeige ICAM1 Antikörper) and interactions between HAoECs and leukocytes

  3. Either MRTF-A (zeige MKL1 Antikörper) or MRTF-B is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.

  4. These results identify SRF and its MRTF cofactors as major transcriptional regulators of endothelial cell junctional stability, guaranteeing physiological functions of the cerebral microvasculature.

  5. Suggest role for nuclear RhoA (zeige RHOA Antikörper) signaling in MRTF-dependent gene expression in smooth muscle cells.

  6. Myocardin (zeige MYOCD Antikörper)-related transcription factor (MRTF)-A (zeige MKL1 Antikörper) and MRTF-B (MKL1 (zeige MKL1 Antikörper) and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development.

  7. MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.

  8. Smad2 (zeige SMAD2 Antikörper) interaction with MRTFB seems to be a novel and important mechanism underlying neural crest cell differentiation to vascular smooth muscle cells.

  9. MRTF-B knockdown leads to increase in S and G2/M populations and downregulation of cyclin (zeige PCNA Antikörper)-CDK (zeige CDK4 Antikörper) inhibitors p27Kip1 (zeige CDKN1B Antikörper), p18Ink4c (zeige CDKN2C Antikörper) and 19Ink4d as well as upregulation of p21Waf1 and cyclin D1 (zeige CCND1 Antikörper).

  10. Data suggest that MKL1 (zeige MKL1 Antikörper) and MKL2 are expressed in megakaryocytes and platelets; megakaryocytes lacking expression of MKL1 (zeige MKL1 Antikörper) and/or MKL2 have both defective megakaryocytopoiesis and thrombopoiesis.

MKL2 Antigen-Profil

Protein Überblick

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.

Genbezeichner und Symbole assoziert mit MKL2

  • MKL1/myocardin like 2 (MKL2) Antikörper
  • MKL1/myocardin like 2 S homeolog (mkl2.S) Antikörper
  • MKL1/myocardin like 2 (mkl2) Antikörper
  • MKL1/myocardin like 2 (Mkl2) Antikörper
  • MKL/myocardin-like 2 (Mkl2) Antikörper
  • ENSMUSG00000075401 Antikörper
  • Gt4-1 Antikörper
  • MGC145857 Antikörper
  • mKIAA1243 Antikörper
  • MRTF-B Antikörper
  • mrtf-b-A Antikörper
  • Mrtfb Antikörper
  • npd001 Antikörper

Bezeichner auf Proteinebene für MKL2

MKL/myocardin-like protein 2 , megakaryoblastic leukemia 2 , myocardin-related transcription factor B , MRTF-B , xMRTF-B , MKL/myocardin-like 2 , megakaryoblastic leukemia 2 protein , gene trap insertion site 4-1

GENE ID SPEZIES
57496 Homo sapiens
378496 Xenopus laevis
780107 Xenopus (Silurana) tropicalis
100050736 Equus caballus
100073360 Ornithorhynchus anatinus
100350900 Oryctolagus cuniculus
100362470 Rattus norvegicus
239719 Mus musculus
100731881 Cavia porcellus
511461 Bos taurus
416421 Gallus gallus
489999 Canis lupus familiaris
Ausgewählte Anbieter für anti-MKL2 (MKL2) Antikörper
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