anti-MDM2 Oncogene, E3 Ubiquitin Protein Ligase (MDM2) Antikörper

MDM2 is a target gene of the transcription factor tumor protein p53.

Alle Antikörper anzeigen Gen GeneID UniProt
MDM2 4193 Q00987
MDM2    
MDM2    
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Top anti-MDM2 Oncogene, E3 Ubiquitin Protein Ligase Antikörper auf antikoerper-online.de

Showing 10 out of 66 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert IHC (fro), IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: MDM2/HDM2 Antibody (SMP14) [ABIN251181] - IHC analysis of formalin fixed paraffin embedded tissue section of human breast cancer xenograft using MDM2/HDM2 antibody (clone SMP14) at 1:100 dilution. Several of the cancer cells developed a strong nuclear with weak cytoplasmic immunostaining of MDM2. Immunohistochemistry-Paraffin: MDM2/HDM2 Antibody (SMP14) [ABIN251181] - IHC analysis of formalin fixed paraffin embedded tissue section of human breast cancer xenograft using MDM2/HDM2 antibody (clone SMP14) at 1:100 dilution. Several of the cancer cells developed a strong nuclear with weak cytoplasmic immunostaining of MDM2. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$446.35
Details
Human Kaninchen Unkonjugiert ChIP, ICC, IF, IHC, IHC (p), IP, WB Western Blot: MDM2 Antibody [NBP2-17247] - Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC C: BCL-1 7. 5% SDS PAGE gel, diluted at 1:1000. Western Blot: MDM2 Antibody [NBP2-17247] - Sample (30 ug of whole cell lysate) A: A549 7. 5% SDS PAGE gel, diluted at 1:3000. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$516.98
Details
Human Maus Unkonjugiert ELISA, ICC, IF, IHC, IP, WB Western Blot: MDM2/HDM2 Antibody (SMP 14) [NBP2-50503] - Detection of MDM2 in two cell line lysates. Western Blot: MDM2/HDM2 Antibody (SMP 14) [NBP2-50503] - Strip and reprobe blot with 2A10 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$347.48
Details
Human Ziege Unkonjugiert ELISA, WB ABIN251295 (0.3?g/ml) staining of Human Liver lysate (35?g protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Western Blot: MDM2/HDM2 Antibody [ABIN251295] - Analysis of MDM2/HDM2(isoform) using this antibody at 0.1 ug/ml in Human Liver lysate (35ug protein in RIPA buffer). 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$488.73
Details
Human Maus Unkonjugiert ELISA, WB Western Blot: MDM2/HDM2 Antibody (HDM2-323)  - Whole extracts of HEK-293 cells overexpressing human (lane 1) or mouse (lane 2) MDM2 were separated on SDS-PAGE and probed with 2 ug/mL Monoclonal Anti-MDM2 Clone: HDM2-323. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$418.10
Details
Human Kaninchen Unkonjugiert IP, ELISA, WB 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$587.60
Details
Human Huhn Unkonjugiert WB Western Blot: MDM2/HDM2 Antibody [ABIN268488] - E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-MTHFD2 ) 0.05 mg Anmelden zum Anzeigen 7 bis 9 Tage
$587.60
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$418.10
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB Western Blot: MDM2/HDM2 Antibody [NBP2-30041] - Western blot analysis of MDM2 antibody (S166) (NBP2-30041) in 293 cell line lysates (35ug/lane). MDM2 (arrow) was detected using the purified Pab. Immunocytochemistry/Immunofluorescence: MDM2/HDM2 Antibody [NBP2-30041] - Confocal immunofluorescent analysis of MDM2 Antibody (S166) (NBP2-30041) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue). 0.4 mL Anmelden zum Anzeigen 10 bis 13 Tage
$516.98
Details
Human Maus Alexa Fluor 488 IHC (fro), IHC (p), WB   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$559.35
Details

Am meisten referenzierte anti-MDM2 Oncogene, E3 Ubiquitin Protein Ligase Antikörper

  1. Human Monoclonal MDM2 Primary Antibody für IHC (fro), IHC (p) - ABIN251181 : Sionov, Moallem, Berger, Kazaz, Gerlitz, Ben-Neriah, Oren, Haupt: c-Abl neutralizes the inhibitory effect of Mdm2 on p53. in The Journal of biological chemistry 1999 (PubMed)
    Show all 18 Pubmed References

  2. Human Polyclonal MDM2 Primary Antibody für ELISA, WB - ABIN251295 : Bond, Hu, Bond, Robins, Lutzker, Arva, Bargonetti, Bartel, Taubert, Wuerl, Onel, Yip, Hwang, Strong, Lozano, Levine: A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. in Cell 2004 (PubMed)

  3. Human Polyclonal MDM2 Primary Antibody für ChIP, ICC - ABIN4333337 : Ullah, Rosendahl, Izzi, Bergmann, Pihlajaniemi, Mäki, Myllyharju: Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways. in Scientific reports 2017 (PubMed)

Weitere Antikörper gegen MDM2 Oncogene, E3 Ubiquitin Protein Ligase Interaktionspartner

Human MDM2 Oncogene, E3 Ubiquitin Protein Ligase (MDM2) Interaktionspartner

  1. H3K9ac was a specific target for Ras-ERK1/2 signaling pathway. H3K9 acetylation can be modulated by HDAC2 and MDM2-depedent degradation of PCAF. The revealed regulation provides a better understanding of Ras-ERK1/2 signaling in tumorigenesis.

  2. this is the first study demonstrating that MDM2 could play an important role in the molecular mechanisms of recurrence/metastasis of Epithelioid angiomyolipoma.

  3. High-level MDM2 amplification determined by FISH strongly favors dedifferentiated liposarcoma over malignant peripheral nerve sheath tumor.

  4. Chromatin modification by Mdm2 and PRC1 ensures smooth DNA replication through the avoidance of R-loop formation.

  5. Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.

  6. HDMX and HDM2 interact via their respective C-terminal RING domains but here we show that the presence of p53 induces an N-terminal interface under normal cellular conditions.

  7. a novel uORF-based regulatory mechanism that is employed under conditions of hyperosmotic stress by at least two human mRNAs, coding for translation reinitiation/recycling factor eIF2D and E3 ubiquitin ligase MDM2. This novel mode of translational control selectively downregulates their expression and requires as few as one uORF.

  8. MDM2 amplification in large-duct intrahepatic cholangiocarcinomas is more common than presently considered, and it may represent a unique biliary carcinogenetic process in which KRAS and TP53 mutations are less frequent.

  9. A role for PDLIM7 and CDH18, regulating MDM2 protein in CDK4/6 inhibitor-treated cells.

  10. the inhibition of HDAC activity by suberoylanilide hydroxamic acid rescued NCL acetylation accompanied by the loss of mouse double minute 2 homolog (MDM2)-mediated ubiquitination.

  11. USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer.

  12. Homeobox A13 (HOXA13) played a role of carcinogenesis through directly down-regulating dehydrogenase/reductase 2 (DHRS2) to increase proto-oncogene proteins c-mdm2 (MDM2).

  13. The findings uncover a novel mechanism for the regulation of Mdm2 and reveal MARCH7 as an important regulator of the Mdm2-p53 pathway.

  14. A combination of MDM4/MDM2 knockdown and conventional cytotoxic drugs could be a promising treatment strategy for wtTP53/highMDM4 gastrointestinal cancers.

  15. Study found significantly higher MDM2 single nucleotide polymorphism 309 GG genotype and G allele frequencies in the Brazilian Li-Fraumeni syndrome cohort than in controls.

  16. Our case-control analysis revealed that MDM2 rs937283 was associated with the susceptibility to breast and liver cancer, but not cervical, colon, or rectal cancer.

  17. Meta-analysis found that significant association between the MDM2 rs2279744 polymorphism and increased retinoblastoma (Rb) risk, while MDM2 rs937283 polymorphism was associated with significantly decreased RB risk. However, as to the P21 rs1801270 polymorphism, a statistically significant association was not identified for RB.

  18. Meta-analysis suggested that MDM2 SNP309 polymorphism increased the risk of endometrial cancer significantly, especially in endometrioid and Type I endometrial cancer, indicating MDM2 could serve as a potential diagnostic factor marker for endometrial cancer.

  19. The Numb-Mdm2 interaction represents a fuzzy complex mediated by a short Numb sequence encompassing its alternatively spliced exon 3 (Ex3), which is necessary and sufficient to inhibit Mdm2 and prevent p53 degradation.

  20. It has been shown that MDM2 and MDMX are targetable vulnerabilities within TP53-wild-type T-cell lymphomas.

MDM2 Oncogene, E3 Ubiquitin Protein Ligase (MDM2) Antigen-Profil

Protein Überblick

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Genbezeichner und Symbole assoziert mit MDM2

  • MDM2 proto-oncogene (MDM2) Antikörper
  • ACTFS Antikörper
  • hdm2 Antikörper
  • HDMX Antikörper

Bezeichner auf Proteinebene für MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2

GENE ID SPEZIES
4193 Homo sapiens
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