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MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. Zusätzlich bieten wir Ihnen MAP/microtubule Affinity-Regulating Kinase 2 Antikörper (97) und MAP/microtubule Affinity-Regulating Kinase 2 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
In the modeled structure of inactive MARK2, activation segment occludes the enzyme active site and assumes a relatively stable position.
In conclusion, baicalin and DDP (zeige TIMM8A ELISA Kits) were synergistic at inhibiting proliferation and invasion of human lung cancer cells at appropriate dosages and incubation time in the presence or absence of DDP (zeige TIMM8A ELISA Kits) resistance. The attenuation of DDP (zeige TIMM8A ELISA Kits) resistance was associated with downregulation of MARK2 and p-Akt (zeige AKT1 ELISA Kits).
MARK2 plays a role in promoting malignant phenotypes of lung cancer.
Phosphorylation of RNF41 (zeige RNF41 ELISA Kits) by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.
induces asymmetric inheritance of plasma membrane domains via LGN (zeige GPSM2 ELISA Kits)-dependent mitotic spindle orientation in proliferating hepatocytes
Perturbation of PAR1b and SHP2 (zeige PTPN11 ELISA Kits) by CagA (zeige S100A8 ELISA Kits) underlies the oncogenic potential of CagA (zeige S100A8 ELISA Kits).
The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.
Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN (zeige GPSM2 ELISA Kits)-NuMA (zeige NUMA1 ELISA Kits) to yield the distinct epithelial division phenotypes.
automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.
The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3 (zeige F2RL2 ELISA Kits).
These results indicate that the basal localization of Par-1b in the outer epithelial cells is required for myoepithelial cell compression, and Par-1b is required for myoepithelial differentiation, regardless of its localization.
data suggest ectopic PAR1 (zeige F2R ELISA Kits) expression is not tolerated in mouse platelets and indicate a different approach is required to develop a small animal model for the purpose of any future preclinical testing of PAR (zeige AFG3L2 ELISA Kits) antagonists as anti-platelet drugs
a model whereby MARK2 negatively regulates insulin (zeige INS ELISA Kits) sensitivity in peripheral tissue through inhibition of KSR1 (zeige KSR1 ELISA Kits)
ROCK1 (zeige ROCK1 ELISA Kits)/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.
PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap (zeige SRCIN1 ELISA Kits) in dendritic spines.
Par-1b is a regulator of glucose metabolism and adiposity in the whole animal
Interaction of MARK2 with CaMKI (zeige CAMK1 ELISA Kits) results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.
Akt (zeige AKT1 ELISA Kits) enhances the activity of PAR1 (zeige F2R ELISA Kits) to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 (zeige HSP90 ELISA Kits) complex
Coreduction of MARK2 and DCX (zeige DCX ELISA Kits) resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.
ELKL motif kinase 1
, PAR1 homolog b
, Ser/Thr protein kinase PAR-1B
, serine/threonine protein kinase EMK
, serine/threonine-protein kinase MARK2
, serine/threonine kinase