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May involved in cell-cell interactions (By similarity)..
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A novel tumour suppressor gene, MDGA2, which is frequently inactivated by promoter methylation in Gastric cancer was identified. Promoter hypermethylation of MDGA2 represents a prognostic biomarker in patients with early stage Gastric cancer.
This finding provides further support for a link between variants in the MDGA2 gene and specific neuroticism-related phenotypes.
Polymorphisms of rs961616 in MAMDC1 gene were associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese population.
This study demonistrated suggested taht Rostral growth of commissural axons requires the cell adhesion molecule (zeige MCAM Proteine) MDGA2
A novel uncharacterized gene, MAMDC1 (MAM domain containing glycosylphosphatidylinositol anchor 2, also known as MDGA2, MIM (zeige MTSS1 Proteine) 611128), represents a putative susceptibility gene for systemic lupus erythematosus.
MAMDC1 gene is implicated in neuroticism.
results suggest that mutations in MDGA2 contribute to altered cortical processing through the dual disadvantages of elevated excitation and hyperconnectivity.
The neuronal migration deficit caused by loss of Laf4 can be partially rescued by Mdga2 over-expression, revealing an important functional relationship between these genes in a mouse model of intellectual disability.
MDGA binding and suppression of synaptogenic activity was selective for neuroligin-2 (zeige NLGN2 Proteine) and not neuroligin-1 (zeige NLGN1 Proteine) excitatory synapse organizer.
The transgene was inserted into the intronic sequences between exon 3 and exon 4 of the Mdga2 gene;the transgene was highly or under methylated in normal and deformed mice, respectively.
May involved in cell-cell interactions (By similarity).
MAM domain containing 1
, MAM domain-containing glycosylphosphatidylinositol anchor protein 2
, MAM domain-containing protein 1