MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Proteine (MAD2L2)

The protein encoded by MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.

alle Proteine anzeigen Gen GeneID UniProt
Maus MAD2L2 MAD2L2 71890 Q9D752
Human MAD2L2 MAD2L2 10459 Q9UI95
Ratte MAD2L2 MAD2L2 313702 D3Z8D9
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Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,744.22
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,520.83
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Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,520.83
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,520.83
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,520.83
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,520.83
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,520.83
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Weitere Proteine zu MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaktionspartnern

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaktionspartner

  1. Skp2, a confirmed APC (zeige APC Proteine)/C-CDH1 (zeige CDH1 Proteine) substrate and E-cadherin (zeige CDH1 Proteine) destroyer, was increased in TGF-beta1 (zeige TGFB1 Proteine)-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion.

  2. This study demonstrates using super-resolution microscopy that numerous MAD2L2 microfoci are exclusively associated with euchromatin, similar to other factors of the DNA damage response. In the absence of MAD2L2 the amount of heterochromatin demarcated by H3K9me2 was significantly increased.

  3. Increased gonadotropins caused by the absence of functional oocytes and accumulation of DNA damage in cells caused by the lack of repair function could be responsible for the development and progression of ovarian tumors in the Rev7 mutant mouse.

  4. the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs (zeige NR2E3 Proteine)), depending on the growth conditions.

  5. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  6. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  7. These results demonstrated that Rev7 is essential in resolving the replication stalls caused by DNA damage during S phase.

  8. The function of Mad2l2 is essential in PGCs, and thus of high relevance for fertility

  9. Rev7 is essential for PGC (zeige PGC Proteine) maintenance by prevention of apoptotic cell death in the mouse.

  10. identification of the Rev7 binding surface of the Rev1 C-terminal domain

Xenopus laevis MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaktionspartner

  1. We have successfully isolated Xenopus laevis Mad2B and PRCC (zeige PRCC Proteine) cDNAs, so the well-established animal model Xenopus laevis can be used as a powerful system to study in detail the role of xPRCC (zeige PRCC Proteine) and xMad2B in the intricate processes of cell cycle control.

Human MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaktionspartner

  1. Skp2, a confirmed APC (zeige APC Proteine)/C-CDH1 (zeige CDH1 Proteine) substrate and E-cadherin (zeige CDH1 Proteine) destroyer, was increased in TGF-beta1 (zeige TGFB1 Proteine)-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion.

  2. structure-based interaction analyses revealed an unprecedented mechanism involving CAMP's WK motif. Surprisingly, in one of the crystal forms, the MAD2L2-CAMP complex formed a dimeric structure in which the C-terminal region of MAD2L2 was swapped and adopted an immature structure

  3. REV7 is a previously undescribed FA gene, which we term FANCV

  4. Knockdown of REV7 inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) of breast cancer cells. Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT (zeige ITK Proteine) of breast cancer cells.

  5. hMAD2 also binds to the hREV7-binding sequence in hREV3, whereas hMAD2 does not bind to a similar sequence in ADAM9 (zeige ADAM9 Proteine) or ELK-1 (zeige ELK1 Proteine) and hREV7 does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20.

  6. data establish MAD2L2 as a crucial contributor to the control of DNA repair activity by 53BP1 that promotes NHEJ by inhibiting 5' end resection downstream of RIF1

  7. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  8. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  9. Rev7 is essential for mutagenesis and S phase progression in UV-irradiated fibroblasts.

  10. These findings indicate that depletion of REV7 enhances sensitivity to cisplatin treatment in ovarian clear cell carcinoma (CCC), suggesting that REV7 is a candidate molecular target in CCC management.

MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Protein Überblick

Protein Überblick

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.

Genbezeichner und Symbole assoziert mit MAD2L2

  • mitotic arrest deficient 2 like 2 (mad2l2)
  • mitotic arrest deficient 2 like 2 (MAD2L2)
  • MAD2 mitotic arrest deficient-like 2 (Mad2l2)
  • mitotic arrest deficient 2 like 2 S homeolog (mad2l2.S)
  • mitotic arrest deficient 2 like 2 (Mad2l2)
  • MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2)
  • si:dkey-23c22.2 (si:dkey-23c22.2)
  • 2310033C13Rik Protein
  • mad2B Protein
  • mad2l2 Protein
  • mad2l2-A Protein
  • POLZ2 Protein
  • REV7 Protein
  • xMAD2L2 Protein
  • zgc:110299 Protein

Bezeichner auf Proteinebene für MAD2L2

MAD2-like protein 2 , Mitotic arrest deficient 2-like protein 2 , mitotic spindle assembly checkpoint protein MAD2B , MAD2 homolog , mitotic arrest deficient 2-like protein 2 , Mitotic arrest defective protein 2B , MAD2 (mitotic arrest deficient, yeast, homolog)-like 2 , REV7 homolog , hREV7 , mitotic arrest deficient homolog-like 2 , polymerase (DNA-directed), zeta 2, accessory subunit

GENE ID SPEZIES
448122 Xenopus (Silurana) tropicalis
457953 Pan troglodytes
714527 Macaca mulatta
71890 Mus musculus
394380 Xenopus laevis
10459 Homo sapiens
313702 Rattus norvegicus
506605 Bos taurus
419493 Gallus gallus
487443 Canis lupus familiaris
550258 Danio rerio
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