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The product encoded by LPXN is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Zusätzlich bieten wir Ihnen Leupaxin Proteine (6) und Leupaxin Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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this is the first demonstration of a role for the leupaxin in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin (zeige CTNNB1 Antikörper) transcription activity.
The full-length leupaxin binds to the Pyk2 (zeige PTK2B Antikörper)-focal adhesion targeting domain.
Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein (zeige KPTN Antikörper) CaD (zeige CAD Antikörper) and regulates CaD (zeige CAD Antikörper) phosphorylation by recruiting ERK (zeige EPHB2 Antikörper) to highly dynamic structures within PCa (zeige FLVCR1 Antikörper) cells.
Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions.
first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors
leupaxin functions as a paxillin (zeige PXN Antikörper) counterpart that potently suppresses the tyrosine phosphorylation of paxillin (zeige PXN Antikörper) during integrin signaling.
leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex
Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP.
These data demonstrate that LPXN forms a signaling complex with Pyk2 (zeige PTK2B Antikörper), c-Src (zeige SRC Antikörper), and PTP-PEST (zeige PTPN12 Antikörper) to regulate migration of prostate cancer cells.
Leupaxin plays an inhibitory role in BCR (zeige BCR Antikörper) signaling and B cell function.
Association of the scaffold protein (zeige HOMER1 Antikörper) LPXN with Src (zeige SRC Antikörper) adds further complexity to the organization of the podosomal signaling complex in osteoclasts.
Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development.
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.