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The protein encoded by LAIR2 is a member of the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen LAIR2 Antikörper (49) und LAIR2 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.
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We suggest that LAIR1 and LAIR2 genetic variants are associated with regulation of gene expression and variable pemphigus foliaceus susceptibility, and show indirect association of LAIR2 differential mRNA expression with pemphigus foliaceus pathogenesis.
recombinant LAIR-2-Fc inhibits complement-mediated lysis of cells sensitized with anti-HLA antibodies
the presence of high LAIR-2 levels in 74/80 sera from patients with autoimmune thyroid diseases
LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion
Two markers in two different genes (CNOT3 and LAIR2) showed significant association with ankylosing spondylitis.
LAIR-2/Fc has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis.
LAIR-2 prevents binding of human LAIR-1 to collagens and LAIR-1 cross-linking in vitro, suggesting that the protein has an immunoregulatory function in vivo.
Human collagen II peptides II-17, -27, -30, -35, -38, -42, -49 & -56; and collagen III peptides III-1, 5, -8, -10, -12, -13, -22, -30, -38, -40, -44, -45, and -51 specifically interacted with hLAIR-2 expressed on K562 cells
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.
, leukocyte-associated Ig-like receptor 2
, leukocyte-associated Ig-like receptor-2
, leukocyte-associated immunoglobulin-like receptor 2