Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 Proteine (LILRA2)

LILRA2 encodes a member of the leukocyte Ig-like receptor (LIR) family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. Zusätzlich bieten wir Ihnen Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 Antikörper (75) und Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LILRA2 11027 Q8N149
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$688.00
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Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Wheat germ Human Unkonjugiert   10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$654.29
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HEK-293 Cells Human His tag   10 μg Anmelden zum Anzeigen 8 bis 11 Tage
$227.70
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Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
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HEK-293 Cells Human AVI tag,Biotin,His tag   200 μg Anmelden zum Anzeigen 5 Days
$1,518.00
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LILRA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , , ,

Weitere Proteine zu Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) Interaktionspartnern

Human Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) Interaktionspartner

  1. LILRA2 recognizes microbially cleaved antibodies and activates innate immunity, suggesting that LILRA2 detects dangerous immunological situations in which antibodies are destroyed by pathogens.

  2. LILRA2-mediated activation of monocytes is significantly different to LPS (zeige IRF6 Proteine) and that LILRA2 selectively modulates LPS (zeige IRF6 Proteine)-mediated monocyte activation and FcgammaRI (zeige FCGR1A Proteine)-dependent phagocytosis.

  3. LIR7 is an activating receptor for eosinophils that elicited the release of cytotoxic granule proteins, de novo lipid mediator generation, and cytokine release through vesicular transport

  4. Cross-linking of basophil LIR7 resulted in the concentration-dependent net release of histamine and cysteinyl leukotrienes that were maximal at 30 minutes, and of IL-4 (zeige IL4 Proteine) that was maximal at 4 hours

  5. Progenitor mast cells expressed cell surface activating LILRA2. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface.

  6. LILRA2 activation, by altering GM-CSF (zeige CSF2 Proteine)-induced monocyte differentiation into immature DC, provides a mechanism for down-regulating the ability of the innate immune system to activate the adaptive T cell response while promoting an inflammatory response.

  7. LILRA2 Delta 419-421 isoform encoded by the splice site SNP may play a role in systemic lupus erythematosus and microscopic polyangiitis.

  8. The authors report the LILRA2 extracellular D1D2 domain crystal structure, which reveals structural shifts of the corresponding MHC-binding amino acid residues in comparison with LILR B1/B2, explaining its non-binding to MHC molecules.

Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) Protein Überblick

Protein Überblick

This gene encodes a member of the leukocyte Ig-like receptor (LIR) family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The LIR family comprises of activating (subfamily A) and inhibitory (subfamily B) cell-surface receptors. The LIR encoded by this gene was shown to be an activating receptor for eosinophils that elicited the release of cytotoxic granule proteins, de novo lipid mediator generation, and cytokine release through vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit LILRA2

  • leukocyte immunoglobulin like receptor A2 (LILRA2)
  • CD85H Protein
  • ILT1 Protein
  • LIR-7 Protein
  • LIR7 Protein

Bezeichner auf Proteinebene für LILRA2

CD85 antigen-like family member H , ILT-1 , immunoglobulin-like transcript 1 , leukocyte immunoglobulin-like receptor 7 , leukocyte immunoglobulin-like receptor subfamily A member 2 , leukocyte immunoglobulin-like receptor subfamily A member 2 soluble

GENE ID SPEZIES
11027 Homo sapiens
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