Leucyl-tRNA Synthetase 2, Mitochondrial Proteine (LARS2)

LARS2 encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Zusätzlich bieten wir Ihnen LARS2 Antikörper (39) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LARS2 23395 Q15031
Ratte LARS2 LARS2 363172  
Maus LARS2 LARS2 102436 Q8VDC0
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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LARS2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Weitere Proteine zu Leucyl-tRNA Synthetase 2, Mitochondrial (LARS2) Interaktionspartnern

Human Leucyl-tRNA Synthetase 2, Mitochondrial (LARS2) Interaktionspartner

  1. IARS2 knockdown inhibits proliferation, suppresses colony formation, and causes cell cycle arrest in AGS (zeige JAG1 Proteine) cells.

  2. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4 (zeige HSD17B4 Proteine), LARS2, CLPP (zeige CLPP Proteine) and C10orf2 (zeige C10ORF2 Proteine)

  3. This represents the first independent replication of the involvement of LARS2 mutations in Perrault syndrome, contributing valuable information for the further understanding of this disease

  4. analysis of the CP1 domain in human mitochondrial leucyl-tRNA synthetase

  5. Leucyl tRNA synthetase is able to partially rescue defects caused by mutations in non-cognate itochondrial-tRNAs.

  6. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome.

  7. No evidence to support previous data indicating a role in type 2 diabetes susceptibility in humans with LARS2 single nucleotide polymorphisms

  8. Upregulation of LARS2 is a hallmark of 324A>G mutation. The accumulation of 3243A>G mutation in the brain may have a pathophysiologic role in bipolar disorder and schizophrenia.

  9. In this study, we provide evidence that the LARS2 gene may represent a novel type 2 diabetes susceptibility gene.

  10. There was investigated whether overexpression of human mitochondrial LeuRS suppressed translation and respiratory chain defects associated with the pathogenic A3243G mutation in human cells.

LARS2 Protein Überblick

Protein Überblick

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.

Genbezeichner und Symbole assoziert mit LARS2

  • leucyl-tRNA synthetase 2, mitochondrial (LARS2)
  • leucyl-tRNA synthetase 2 L homeolog (lars2.L)
  • probable leucine--tRNA ligase, mitochondrial (LOC100163590)
  • leucyl-tRNA synthetase 2 (lars2)
  • leucyl-tRNA synthetase 2, mitochondrial (lars2)
  • leucyl-tRNA synthetase 2, mitochondrial (Lars2)
  • leucyl-tRNA synthetase, mitochondrial (Lars2)
  • AI035546 Protein
  • Kiaa0028 Protein
  • LARS2 Protein
  • LEURS Protein
  • MGC80460 Protein
  • PRLTS4 Protein

Bezeichner auf Proteinebene für LARS2

leucyl-tRNA synthetase 2, mitochondrial , probable leucyl-tRNA synthetase, mitochondrial , Probable leucyl-tRNA synthetase, mitochondrial , leuRS , leucine--tRNA ligase , probable leucine--tRNA ligase, mitochondrial , probable leucyl-tRNA synthetase, mitochondrial-like , leucine tRNA ligase 2, mitochondrial , leucine tRNA ligase 2, mitocondrial , leucine translase , leucyl-tRNA synthetase, mitochondrial

GENE ID SPEZIES
420702 Gallus gallus
443989 Xenopus laevis
476652 Canis lupus familiaris
504609 Bos taurus
714224 Macaca mulatta
739246 Pan troglodytes
100082885 Ornithorhynchus anatinus
100163590 Acyrthosiphon pisum
100174294 Pongo abelii
100358356 Oryctolagus cuniculus
100379697 Xenopus (Silurana) tropicalis
100484574 Ailuropoda melanoleuca
100540484 Meleagris gallopavo
100556212 Anolis carolinensis
23395 Homo sapiens
363172 Rattus norvegicus
102436 Mus musculus
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