Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 Proteine (Lrig1)

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. Zusätzlich bieten wir Ihnen Lrig1 Antikörper (68) und Lrig1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Lrig1 26018 Q96JA1
Lrig1 16206 P70193
Ratte Lrig1 Lrig1 312574  
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Showing 6 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Human Cells Maus His tag 50 μg Anmelden zum Anzeigen 14 bis 16 Tage
$250.80
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$765.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Human Cells Maus His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$187.50
Details

Lrig1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) Interaktionspartnern

Human Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) Interaktionspartner

  1. MiR (zeige MLXIP Proteine)-183 overexpression promoted radioresistance of glioblastoma via down-regulating LRIG1 and increasing the activity of EFGR (zeige EGFR Proteine)/Akt (zeige AKT1 Proteine).

  2. LRIG1 is a negative regulator of RET2A and RET2B and is also downregulated in papillary and medullary thyroid carcinoma

  3. LRIG1 expression in human GC tissues is inversely correlated with miR (zeige MLXIP Proteine)-20a and EGFR (zeige EGFR Proteine).

  4. Role of LRIG1 in cancer [review]

  5. LRIG1 expression may represent a barrier to EMT (zeige ITK Proteine)

  6. LRIG1 role in the atrophic epidermis

  7. Downregulation of LRIG1 expression in oral verrucous carcinoma tissue is reported.

  8. LRIG1, as a negative mediated gene of tumor, can inhibit biological function of PAs (zeige PASK Proteine) via inhibiting PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and Ras/Raf (zeige RAF1 Proteine)/ERK (zeige EPHB2 Proteine) pathways, and it might be a new target for gene therapy ofPituitary adenomas

  9. LRIG1 and Fascin-1 (zeige FSCN1 Proteine) were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.

  10. Results suggest that the LRIG1could negatively control MRP-1 (zeige MDM4 Proteine) and the apoptosis to improve the sensitivity of VP16-related chemotherapy.

Mouse (Murine) Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) Interaktionspartner

  1. Lrig1 marks gastric corpus epithelial progenitor cells capable of repopulating the damaged oxyntic mucosa by differentiating into normal gastric lineage cells in mouse stomach.

  2. findings reveal a novel and essential role of Lrig1 in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB (zeige NTRK2 Proteine) with Lrig1 represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF (zeige BDNF Proteine) during brain development

  3. LRIG1 role in the atrophic epidermis

  4. LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin

  5. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (zeige AREG Proteine) and Egfr (zeige EGFR Proteine) activity.

  6. LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.

  7. Loss of one Apc (zeige APC Proteine) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.

  8. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.

  9. LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (zeige STAT3 Proteine).

  10. A review summarizes the data that LRIG1 is a ERBB (zeige EGFR Proteine) negative regulator and tumour suppressor.

Lrig1 Protein Überblick

Protein Überblick

Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).

Genbezeichner und Symbole assoziert mit Lrig1

  • leucine rich repeats and immunoglobulin like domains 1 (LRIG1)
  • leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)
  • D6Bwg0781e Protein
  • Img Protein
  • LIG-1 Protein
  • LIG1 Protein

Bezeichner auf Proteinebene für Lrig1

leucine-rich repeat protein LRIG1 , leucine-rich repeats and immunoglobulin-like domains protein 1 , ortholog of mouse integral membrane glycoprotein LIG-1 , integral membrane glycoprotein

GENE ID SPEZIES
26018 Homo sapiens
16206 Mus musculus
312574 Rattus norvegicus
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