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Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. Zusätzlich bieten wir Ihnen Lrig1 Antikörper (75) und Lrig1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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LRIG1 is a negative regulator of RET2A and RET2B and is also downregulated in papillary and medullary thyroid carcinoma
LRIG1 expression in human GC tissues is inversely correlated with miR (zeige MLXIP Proteine)-20a and EGFR (zeige EGFR Proteine).
Role of LRIG1 in cancer [review]
LRIG1 expression may represent a barrier to EMT (zeige ITK Proteine)
LRIG1 role in the atrophic epidermis
Downregulation of LRIG1 expression in oral verrucous carcinoma tissue is reported.
LRIG1, as a negative mediated gene of tumor, can inhibit biological function of PAs (zeige PASK Proteine) via inhibiting PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and Ras/Raf (zeige RAF1 Proteine)/ERK (zeige EPHB2 Proteine) pathways, and it might be a new target for gene therapy ofPituitary adenomas
LRIG1 and Fascin-1 (zeige FSCN1 Proteine) were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.
Results suggest that the LRIG1could negatively control MRP-1 (zeige MDM4 Proteine) and the apoptosis to improve the sensitivity of VP16-related chemotherapy.
ERa-dependent expression of LRIG1 dampens ErbB3 (zeige ERBB3 Proteine) signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 (zeige ERBB3 Proteine) accumulation, enhanced ErbB3 (zeige ERBB3 Proteine) signaling to cell survival pathways
findings reveal a novel and essential role of Lrig1 in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB (zeige NTRK2 Proteine) with Lrig1 represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF (zeige BDNF Proteine) during brain development
LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin
a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (zeige AREG Proteine) and Egfr (zeige EGFR Proteine) activity.
LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.
Loss of one Apc (zeige APC Proteine) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.
At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.
LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (zeige STAT3 Proteine).
A review summarizes the data that LRIG1 is a ERBB (zeige EGFR Proteine) negative regulator and tumour suppressor.
LRIG1 Loss of heterozygosity (LOH) is frequent across cancers and its loss is an early event in the development of human squamous carcinomas.
Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).
leucine-rich repeat protein LRIG1
, leucine-rich repeats and immunoglobulin-like domains protein 1
, ortholog of mouse integral membrane glycoprotein LIG-1
, integral membrane glycoprotein