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Promotes neurite outgrowth in hippocampal neurons.
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SALM3 regulates excitatory synapse development and locomotion behavior.
LRFN4 complexed with 14-3-3s and NCK1 to mediate elongation in monocytic cells via Rac-1-mediated actin cytoskeleton reorganization
Data indicate that LRFN4 signaling plays an important role in the migration of monocytes/macrophages.
Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth.
Expression of SALM family proteins SALM3 and SALM5 (zeige LRFN5 Proteine) in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons.
Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).
fibronectin type III, immunoglobulin and leucine rich repeat domains 6
, leucine-rich repeat and fibronectin type-III domain-containing protein 4
, synaptic adhesion-like molecule 3
, leucine rich repeat and fibronectin type III domain containing 4