Leucine Rich Repeat Containing 8 Family, Member A Proteine (LRRC8A)

LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. Zusätzlich bieten wir Ihnen LRRC8A Antikörper (48) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LRRC8A 56262 Q8IWT6
LRRC8A 241296 Q80WG5
Ratte LRRC8A LRRC8A 311846 Q4V8I7
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Top LRRC8A Proteine auf antikoerper-online.de

Showing 6 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,639.51
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

LRRC8A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) Interaktionspartnern

Human Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) Interaktionspartner

  1. LRRC8A channels support TNFalpha (zeige TNF Proteine)-induced superoxide production by Nox1 (zeige NOX1 Proteine) which is required for receptor endocytosis.

  2. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (zeige INS Proteine) sensitivity and glucose tolerance.

  3. LRRC8 channels transport the neurotransmitters glutamate (zeige GRIN1 Proteine), aspartate and gamma-aminobutyric acid (GABA) and the co-activator D-serine.

  4. It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 (zeige SLC31A1 Proteine) and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A (zeige ATP7A Proteine), ATP7B (zeige ATP7B Proteine)), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.

  5. LRRC8A is an essential regulator of cisplatin induced p53 (zeige TP53 Proteine) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2 (zeige MDM2 Proteine), as well as activation of caspase-9 (zeige CASP9 Proteine) and -3 in tumor cell lines.

  6. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  7. These data suggest that LRRC8A is associated with the deceleration mechanism of Volume-sensitive outwardly rectifying anion channel inactivation, while none of LRRC8 members is related to the acceleration mechanism.

  8. Study identified SWELL1 (LRRC8A), a member of a four-transmembrane protein family with unknown function, as essential for hypotonicity-induced iodide influx. SWELL1 is localized to the plasma membrane, and its knockdown dramatically reduces endogenous volume-regulated anion channel currents and regulatory cell volume decrease in various cell types.

  9. Genomic disruption of LRRC8A ablated volume-regulated anion channel (VRAC) currents. Cells with disruption of all five LRRC8 genes required LRRC8A cotransfection with other LRRC8 isoforms to reconstitute VRAC currents.

  10. LRRC8 is required for B cell development.

Mouse (Murine) Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) Interaktionspartner

  1. The SWELL1 induction occurs in insulin (zeige INS Proteine)- sensitive tissues (liver and adipose) in the setting of over-nutrition and contributes to improved systemic glycemia by supporting enhanced insulin (zeige INS Proteine)-sensitivity.

  2. Lrrc8a (SWELL1) depletion in MIN6 Insulinoma (zeige RPS15 Proteine) cells and islets significantly impairs glucose-stimulated insulin (zeige INS Proteine) secretion.

  3. LRRC8A-dependent volume-regulated anion channel activity is dispensable for T-cell development and function

  4. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (zeige INS Proteine) sensitivity and glucose tolerance.

  5. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  6. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

LRRC8A Protein Überblick

Protein Überblick

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Genbezeichner und Symbole assoziert mit LRRC8A

  • leucine rich repeat containing 8 VRAC subunit A (LRRC8A)
  • leucine rich repeat containing 8A (Lrrc8a)
  • leucine rich repeat containing 8 VRAC subunit A (Lrrc8a)
  • leucine rich repeat containing 8 VRAC subunit Aa (lrrc8aa)
  • leucine-rich repeat containing 8 family member A S homeolog (lrrc8a.S)
  • leucine rich repeat containing 8 family member A (LRRC8A)
  • AGM5 Protein
  • LLRC8A Protein
  • Lrrc8 Protein
  • mKIAA1437 Protein
  • wu:fb18g12 Protein
  • wu:fi21b10 Protein

Bezeichner auf Proteinebene für LRRC8A

leucine-rich repeat-containing protein 8A , leucine-rich repeat-containing 8 , leucine rich repeat containing 8A , leucine rich repeat containing 8 family member A , volume-regulated anion channel subunit LRRC8A

GENE ID SPEZIES
56262 Homo sapiens
241296 Mus musculus
311846 Rattus norvegicus
327642 Danio rerio
494672 Xenopus laevis
417201 Gallus gallus
491309 Canis lupus familiaris
505605 Bos taurus
100726291 Cavia porcellus
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