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Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Zusätzlich bieten wir Ihnen LRRC26 Antikörper (28) und viele weitere Produktgruppen zu diesem Protein an.
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Suggest that BK channel modulation by auxiliary gamma subunits depends on intra- and/or juxta-membrane mechanisms.
Regulation of the Ca(2+)- and voltage-activated large conductance Ca(2+)-activated K(+) (BK) channel by associated gamma1-subunits, was investigated.
The role of CAPC in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment.
in non-excitable LNCaP prostate cancer cells, BK channels can be activated at negative voltages without rises in [Ca(2+)](i) through their complex with an auxiliary protein, leucine-rich repeat (LRR)-containing protein 26 (LRRC26)
CAPC transcripts have differential expression in cancer cell lines, and that S-CAPC is translated into a 7.5 kDa protein using a non-AUG start codon.
LRRC26-containing BK channels are competent to contribute to resting K(+) efflux at normal cell membrane potentials with resting cytosolic Ca(2+) concentrations and likely play a critical physiological role in supporting normal secretory function in all secretory epithelial cells.
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.
leucine rich repeat containing 26
, BK channel auxiliary gamma subunit LRRC26
, BK channel auxilliary gamma subunit LRRC26
, cytokeratin associated protein
, cytokeratin-associated protein in cancer
, leucine-rich repeat-containing protein 26