Left-Right Determination Factor 1 Proteine (LEFTY1)

LEFTY1 encodes a member of the TGF-beta family of proteins. Zusätzlich bieten wir Ihnen Left-Right Determination Factor 1 Antikörper (83) und Left-Right Determination Factor 1 Kits (27) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LEFTY1 13590 Q64280
LEFTY1 498299  
LEFTY1 10637 O75610
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
HEK-293 Cells Human Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$1,250.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$749.00
Details
Escherichia coli (E. coli) Ratte His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$768.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 4 Days
$177.10
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$653.82
Details

LEFTY1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Rat (Rattus)

Human , , ,
, ,

Weitere Proteine zu Left-Right Determination Factor 1 (LEFTY1) Interaktionspartnern

Zebrafish Left-Right Determination Factor 1 (LEFTY1) Interaktionspartner

  1. Our data do not support the reaction-diffusion model, but instead, we propose that Nodal activates signaling in a temporal window that is defined by a miR (zeige MYLIP Proteine)-430-mediated delay of Lft1/2 translation

  2. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty (zeige LEFTY2 Proteine) range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  3. both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning

  4. Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4 (zeige BMP4 Proteine).

  5. we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 (zeige LEFTY2 Proteine) transcription

  6. study reports that microRNA-430 (miR (zeige MYLIP Proteine)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (zeige TGFB1 Proteine) Nodal antagonist lefty (zeige LEFTY2 Proteine)

Mouse (Murine) Left-Right Determination Factor 1 (LEFTY1) Interaktionspartner

  1. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (zeige LEFTY2 Proteine)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (zeige DNMT3A Proteine) and DNMT3B (zeige DNMT3B Proteine); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (zeige HELLS Proteine) and demethylation crucial to regulation of key signalling pathways in early body plan formation

  2. exogenous lefty1 administered to mice restored the endogenous expression levels of lefty1. The present study demonstrated that lefty1 attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (zeige TGFB1 Proteine) signaling pathway

  3. Lefty-1 may prevent TGFB1 (zeige TGFB1 Proteine)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (zeige SMAD3 Proteine), JNK-3 (zeige MAPK10 Proteine), and BMP-5 (zeige BMP5 Proteine) signaling.

  4. The expression of lefty (zeige LEFTY2 Proteine) in RCC (zeige XRCC1 Proteine) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (zeige XRCC1 Proteine).

  5. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2 (zeige LEFTY2 Proteine)) has a conserved role in left-right asymmetry.

  6. Taken together, these results suggest that optimal expression of Lefty1 and Lefty2 (zeige LEFTY2 Proteine) is critical for the balanced differentiation of mESCs into three germ layers.

  7. Beta-catenin can recrui (zeige KDM1A Proteine)t the H3K4me2/1 d (zeige CTNNB1 Proteine)emethylase LSD1 to regulate the expression of the tumor suppressor Lefty1 in mouse embryonic stem cells.

  8. Lefty (zeige LEFTY2 Proteine) can antagonise TGF-beta1 (zeige TGFB1 Proteine) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.

  9. Cerberus (zeige CER1 Proteine)-like and Lefty-1 function redundantly to modulate Nodal signaling during gastrulation and regulate patterning of the primitive streak

  10. Regulated expression and spatial distribution of lefty (zeige LEFTY2 Proteine) in mouse endometrium confines its biological impact on tissues that undergo remodelling during estrous cycle and pregnancy.

Human Left-Right Determination Factor 1 (LEFTY1) Interaktionspartner

  1. Lefty1 could regulates the cell cycle via modulating the expressions of P57 (zeige CDKN1C Proteine) and cyclin D1 (zeige CCND1 Proteine) and then inhibit the decidualization in vitro.

  2. The mRNA levels of LSD1 (zeige KDM1A Proteine) and beta-catenin (zeige CTNNB1 Proteine) are inversely correlated with the levels of Lefty1 in pancreas and breast tumors.

  3. Reprogrammed cancer cells share the mechanism for expression of Lefty (zeige LEFTY2 Proteine) with induced pluripotent cancer cells (iPS (zeige SLC27A4 Proteine)), thus contributing to the cancerous transformation of iPS (zeige SLC27A4 Proteine) cells.

  4. Data suggest that Lefty (zeige LEFTY2 Proteine) is a novel TGF-beta (zeige TGFB1 Proteine) target molecule that mediates growth inhibition of pancreatic cancer cells.

  5. Findings suggest that Lefty1 is negatively modulated by miR (zeige MLXIP Proteine)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  6. The expression of Nodal in normal and malignant endometrial cells that lack Lefty (zeige LEFTY2 Proteine) strongly supports an important role for this embryonic morphogen (zeige SHH Proteine) in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis.

  7. nodal and the inhibitors of Nodal signaling, lefty (zeige LEFTY2 Proteine)-A and lefty (zeige LEFTY2 Proteine)-B, are down-regulated very early upon differentiation of human embryonic stem cells

  8. LEFTY (zeige LEFTY2 Proteine) proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

Left-Right Determination Factor 1 (LEFTY1) Protein Überblick

Protein Überblick

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Genbezeichner und Symbole assoziert mit LEFTY1

  • lefty1 (lft1)
  • signaling molecule lefty1 (lefty1)
  • left-right determination factor 1 (LOC699924)
  • left-right determination factor 1 (LEFTY1)
  • left-right determination factor 1 (LOC100408003)
  • left-right determination factor 1 (LOC100597378)
  • left right determination factor 1 (Lefty1)
  • AI450052 Protein
  • antivin Protein
  • atv Protein
  • cb73 Protein
  • Ebaf Protein
  • ik:tdsubc_2b12 Protein
  • LEFTB Protein
  • lefty Protein
  • lefty-1 Protein
  • LEFTY1 Protein
  • LEFTYB Protein
  • RGD1561867 Protein
  • Stra3 Protein
  • Tgfb4 Protein
  • xx:tdsubc_2b12 Protein

Bezeichner auf Proteinebene für LEFTY1

signaling molecule lefty1 , left-right determination factor 1 , left-right determination, factor B , left-right determination factor 1-like , TGF-beta-4 , protein lefty-1 , stimulated by retinoic acid gene 3 protein , transforming growth factor beta-4 , left-right determination factor B , protein lefty-B

GENE ID SPEZIES
30145 Danio rerio
100049252 Oryzias latipes
699924 Macaca mulatta
737178 Pan troglodytes
100408003 Callithrix jacchus
100435934 Pongo abelii
100597378 Nomascus leucogenys
13590 Mus musculus
498299 Rattus norvegicus
10637 Homo sapiens
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