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LEFTY1 encodes a member of the TGF-beta family of proteins.
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Theauthors find that zebrafish lefty (zeige LEFTY2 Proteine) mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
Our data do not support the reaction-diffusion model, but instead, we propose that Nodal activates signaling in a temporal window that is defined by a miR (zeige MYLIP Proteine)-430-mediated delay of Lft1/2 translation
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty (zeige LEFTY2 Proteine) range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning
Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4 (zeige BMP4 Proteine).
we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 (zeige LEFTY2 Proteine) transcription
study reports that microRNA-430 (miR (zeige MYLIP Proteine)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (zeige TGFB1 Proteine) Nodal antagonist lefty (zeige LEFTY2 Proteine)
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (zeige LEFTY2 Proteine)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (zeige DNMT3A Proteine) and DNMT3B (zeige DNMT3B Proteine); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (zeige HELLS Proteine) and demethylation crucial to regulation of key signalling pathways in early body plan formation
exogenous lefty1 administered to mice restored the endogenous expression levels of lefty1. The present study demonstrated that lefty1 attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (zeige TGFB1 Proteine) signaling pathway
Lefty-1 may prevent TGFB1 (zeige TGFB1 Proteine)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (zeige SMAD3 Proteine), JNK-3 (zeige MAPK10 Proteine), and BMP-5 (zeige BMP5 Proteine) signaling.
The expression of lefty (zeige LEFTY2 Proteine) in RCC (zeige XRCC1 Proteine) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (zeige XRCC1 Proteine).
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2 (zeige LEFTY2 Proteine)) has a conserved role in left-right asymmetry.
Taken together, these results suggest that optimal expression of Lefty1 and Lefty2 (zeige LEFTY2 Proteine) is critical for the balanced differentiation of mESCs into three germ layers.
Beta-catenin can recrui (zeige KDM1A Proteine)t the H3K4me2/1 d (zeige CTNNB1 Proteine)emethylase LSD1 to regulate the expression of the tumor suppressor Lefty1 in mouse embryonic stem cells.
Lefty (zeige LEFTY2 Proteine) can antagonise TGF-beta1 (zeige TGFB1 Proteine) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.
Cerberus (zeige CER1 Proteine)-like and Lefty-1 function redundantly to modulate Nodal signaling during gastrulation and regulate patterning of the primitive streak
Regulated expression and spatial distribution of lefty (zeige LEFTY2 Proteine) in mouse endometrium confines its biological impact on tissues that undergo remodelling during estrous cycle and pregnancy.
Lefty1 could regulates the cell cycle via modulating the expressions of P57 (zeige CDKN1C Proteine) and cyclin D1 (zeige CCND1 Proteine) and then inhibit the decidualization in vitro.
The mRNA levels of LSD1 (zeige KDM1A Proteine) and beta-catenin (zeige CTNNB1 Proteine) are inversely correlated with the levels of Lefty1 in pancreas and breast tumors.
Reprogrammed cancer cells share the mechanism for expression of Lefty (zeige LEFTY2 Proteine) with induced pluripotent cancer cells (iPS (zeige SLC27A4 Proteine)), thus contributing to the cancerous transformation of iPS (zeige SLC27A4 Proteine) cells.
Data suggest that Lefty (zeige LEFTY2 Proteine) is a novel TGF-beta (zeige TGFB1 Proteine) target molecule that mediates growth inhibition of pancreatic cancer cells.
Findings suggest that Lefty1 is negatively modulated by miR (zeige MLXIP Proteine)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.
The expression of Nodal in normal and malignant endometrial cells that lack Lefty (zeige LEFTY2 Proteine) strongly supports an important role for this embryonic morphogen (zeige SHH Proteine) in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis.
nodal and the inhibitors of Nodal signaling, lefty (zeige LEFTY2 Proteine)-A and lefty (zeige LEFTY2 Proteine)-B, are down-regulated very early upon differentiation of human embryonic stem cells
LEFTY (zeige LEFTY2 Proteine) proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
signaling molecule lefty1
, left-right determination factor 1
, left-right determination, factor B
, left-right determination factor 1-like
, protein lefty-1
, stimulated by retinoic acid gene 3 protein
, transforming growth factor beta-4
, left-right determination factor B
, protein lefty-B