Laminin, gamma 2 (LAMC2) ELISA Kits

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Zusätzlich bieten wir Ihnen LAMC2 Antikörper (55) und LAMC2 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
LAMC2 3918 Q13753
LAMC2 16782  
Anti-Ratte LAMC2 LAMC2 192362  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 6.7 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Am meisten referenzierte LAMC2 ELISA Kits

  1. Human LAMC2 ELISA Kit für Sandwich ELISA - ABIN417810 : Kosanam, Prassas, Chrystoja, Soleas, Chan, Dimitromanolakis, Blasutig, Rückert, Gruetzmann, Pilarsky, Maekawa, Brand, Diamandis: Laminin, gamma 2 (LAMC2): a promising new putative pancreatic cancer biomarker identified by proteomic analysis of pancreatic adenocarcinoma tissues. in Molecular & cellular proteomics : MCP 2013 (PubMed)
    Show all 4 Pubmed References

Weitere ELISA Kits für LAMC2 Interaktionspartner

Human Laminin, gamma 2 (LAMC2) Interaktionspartner

  1. Results indicate that LAMC2-Dox mice expressing the human protein are unable to sustain structuring of a proper basement membrane (BM) at the interface between ameloblasts and maturing enamel. This failure may be related to the atypical composition of the BM in the maturation stage and reaffirms that the atypical BM is essential for enamel maturation.

  2. Overexpression of LAMC2 and knockdown of CD82 (zeige CD82 ELISA Kits) markedly promoted GC cell invasion and activated EGFR (zeige EGFR ELISA Kits)/ERK1/2 (zeige MAPK1/3 ELISA Kits)-MMP7 (zeige MMP7 ELISA Kits) signaling via upregulation of the expression of phosphorylated (p)-EGFR (zeige EGFR ELISA Kits), p-ERK1/2 (zeige MAPK1/3 ELISA Kits) and MMP7 (zeige MMP7 ELISA Kits).

  3. The data presented provide a novel insight into how CDX2 (zeige CDX2 ELISA Kits) is implicated in the transcriptional regulation of LAMC2 in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha (zeige TNF ELISA Kits) is present.

  4. Seventeen percent of the patients were compound heterozygous or homozygous for mutations in the gene LAMA3 (zeige LAMA3 ELISA Kits), 59% carried mutations in both alleles of LAMB3 (zeige LAMB3 ELISA Kits), and 12% were homozygous for mutations in LAMC2. In nine patients with severe generalized JEB, detection of two mutations in one of the genes LAMA3 (zeige LAMA3 ELISA Kits), LAMB3 (zeige LAMB3 ELISA Kits), or LAMC2 was not possible, so the molecular basis of disease could not be clarified completely

  5. Laminin expression depends on Ecad (zeige CDH1 ELISA Kits) loss and allows Ecad (zeige CDH1 ELISA Kits)-defective gastric cancer cells to survive and invade.

  6. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT (zeige ITK ELISA Kits) and may be a potential therapeutic target.

  7. LAMC2 is a novel non-small cell lung cancer prognostic factor.

  8. Diagnostic value of p40 (zeige IL9 ELISA Kits) and LN332 in metaplastic spindle cell carcinoma of the breast was found to be less than that of routinely used markers (p63 (zeige RPE65 ELISA Kits) and cytokeratins). LN332 showed staining in a significant proportion of phyllodes tumours and sarcomas.

  9. The elevated expression of LAMC2 on cancer cells appears to drive tumorigenesis through its interactions with several cell-surface receptors

  10. Molecular expression of MMP-7 (zeige MMP7 ELISA Kits), laminin c2 or EGFR (zeige EGFR ELISA Kits), and their combinations, may be associated with gastric cancer tumor aggressiveness

Mouse (Murine) Laminin, gamma 2 (LAMC2) Interaktionspartner

  1. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT (zeige ITK ELISA Kits) and may be a potential therapeutic target.

  2. Periostin (zeige POSTN ELISA Kits) was associated with laminin gamma2, and this association enhanced the proteolytic cleavage of the laminin gamma2 long form to produce its short form.

  3. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1 (zeige NID1 ELISA Kits), fibulin-1 (zeige FBLN1 ELISA Kits) and fibulin-2 (zeige FBLN2 ELISA Kits)

  4. Thymosin beta(4 (zeige TMSB4X ELISA Kits)) stimulates Lamc2 production independent of TGF-beta (zeige TGFB1 ELISA Kits).

  5. agrin (zeige AGRN ELISA Kits) and perlecan (zeige HSPG2 ELISA Kits) cluster with laminin-2 to contribute to assembly of aneural AChR clusters that precede neural agrin (zeige AGRN ELISA Kits) release as well as affect later NMJ development

  6. Protein production was in excess of the amount required to form heterotrimeric laminin-332 and was associated with the migrating epithelial sheet, suggesting a potential role in wound healing for monomeric laminin-gamma2.

  7. Laminin gamma2 mediates Wnt5a (zeige WNT5A ELISA Kits)-induced invasion of gastric cancer cells.

LAMC2 Antigen-Profil

Beschreibung des Gens

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain\; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.

Genbezeichner und Symbole assoziert mit Laminin, gamma 2 (LAMC2) ELISA Kits

  • laminin subunit gamma 2 (LAMC2) Antikörper
  • laminin, gamma 2 (Lamc2) Antikörper
  • laminin subunit gamma 2 (Lamc2) Antikörper
  • AA589349 Antikörper
  • B2T Antikörper
  • BM600 Antikörper
  • CSF Antikörper
  • EBR2 Antikörper
  • EBR2A Antikörper
  • LAMB2T Antikörper
  • LAMC2 Antikörper
  • LAMNB2 Antikörper

Bezeichner auf Proteinebene für Laminin, gamma 2 (LAMC2) ELISA Kits

laminin 5 gamma 2 subunit , laminin subunit gamma-2 , laminin-5 gamma 2 , laminin, gamma 2 , laminin, gamma 2-like , laminin 5 gamma 2 , BM600-100kDa , CSF 140 kDa subunit , cell-scattering factor 140 kDa subunit , epiligrin subunit gamma , kalinin subunit gamma , ladsin 140 kDa subunit , laminin B2t chain , large adhesive scatter factor 140 kDa subunit , nicein subunit gamma , kalinin/nicein/epiligrin 100 kDa subunit , laminin gamma2 chain , laminin-5 subunit gamma , nicein, 100kD , nicein, 100kDa , lamimin, gamma 2

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