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LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Zusätzlich bieten wir Ihnen LASP1 Antikörper (111) und LASP1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.
Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR (zeige MLXIP ELISA Kits)-145.
LASP1 enhances the expression and secretion of MMPs, favoring breast cancer cell migration and invasiveness.
miR (zeige MLXIP ELISA Kits)-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion
The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker
LASP-1 contributes to the formation and progression of prostate cancer through a NF-kappaappa B pathway.
LASP-1 may essentially involve in the metastasis and growth of CCA (zeige FBN2 ELISA Kits) and clinical significance of LASP-1 may reside in function as a biomarker to predict prognosis and as a promising therapeutic strategy for CCA (zeige FBN2 ELISA Kits) patients by the inhibition of LASP-1 expression
It is a target gene of miR-1.
LASP-1 associated with UHRF1, G9a (zeige EHMT2 ELISA Kits), Snail1 (zeige SNAI1 ELISA Kits) and di- and tri (zeige VANGL2 ELISA Kits)-methylated histoneH3 in a CXCL12 (zeige CXCL12 ELISA Kits)-dependent manner based on immunoprecipitation and proximity ligation assays
LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P (zeige S100P ELISA Kits) via the PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) pathway.
Results defined LASP1 as a direct target gene for HIF1alpha (zeige HIF1A ELISA Kits) upregulation that is critical for metastatic progression of PDAC.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
LIM-nebulette (zeige NEBL ELISA Kits), Lasp-1, and zyxin (zeige ZYX ELISA Kits) may play an important role in the organization of focal adhesions
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM (zeige MMRN1 ELISA Kits) proteins.
Data suggest that there are no functional differences between human and mouse LASP-1.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
LIM and SH3 domain protein 1
, LIM and SH3 protein 1
, lasp1 protein
, metastatic lymph node gene 50 protein
, MLN 50
, 40 kDa phosphoprotein
, phosphoprotein Lasp-1