anti-LEM Domain Containing 3 (LEMD3) Antikörper

This locus encodes a LEM domain-containing protein. Zusätzlich bieten wir Ihnen LEM Domain Containing 3 Kits (4) und LEM Domain Containing 3 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
LEMD3 23592 Q9Y2U8
LEMD3 380664 Q9WU40
LEMD3 680066  
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Top anti-LEM Domain Containing 3 Antikörper auf antikoerper-online.de

Showing 10 out of 27 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Maus Unkonjugiert FACS, IF, IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Hund Maus Unkonjugiert FACS, IF, WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$522.50
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, IHC (p), WB Anti-LEMD3 / MAN1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Maus Unkonjugiert FACS, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Flow cytometric Analysis of Hela cells, using anti-LEMD3 antibody (ABIN2453808), (Red), compared to a nonspecific negative control antibody, (Blue). 0.1 mL Anmelden zum Anzeigen Verfügbar
$451.00
Details
Human Kaninchen Unkonjugiert EIA, IF, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$474.10
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Immunohistochemical analysis of LEMD3 in human colon tissue with LEMD3 polyclonal antibody  at 2.5 ug/mL. Western blot analysis of LEMD3 in human colon tissue with LEMD3 polyclonal antibody  at 1 ug/mL. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$355.73
Details
Human Maus Unkonjugiert IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453229) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 0.1 mL Anmelden zum Anzeigen Verfügbar
$451.00
Details
Human Maus Unkonjugiert FACS, IF, IP, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-LEMD3 mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) 0.1 mL Anmelden zum Anzeigen Verfügbar
$451.00
Details
Human Maus Unkonjugiert FACS, IF, IP, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Immunohistochemical staining of paraffin-embedded liver tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453228, Dilution 1:50) 0.1 mL Anmelden zum Anzeigen Verfügbar
$451.00
Details
Human Maus Unkonjugiert FACS, IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453230) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 0.1 mL Anmelden zum Anzeigen Verfügbar
$482.90
Details

Weitere Antikörper gegen LEM Domain Containing 3 Interaktionspartner

Human LEM Domain Containing 3 (LEMD3) Interaktionspartner

  1. studies demonstrated that lower levels of MAN1 in differentiating MSC (zeige MSC Antikörper) are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis.

  2. Letter/Case-Report: novel frameshift mutation in RNA recognition motif of LEMD3 in patient with Buschke-Ollendorff syndrome.

  3. A novel mutation in LEMD3 splice site results in Buschke-Ollendorff syndrome.

  4. Data indicate that the inner nuclear membrane protein MAN1 directly binds the transcription activator BMAL1 (zeige ARNTL Antikörper) promoter and enhances its transcription.

  5. a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 Antikörper) signaling in which MAN1 competes with transcription factors for binding to Smad2 (zeige SMAD2 Antikörper) and Smad3 (zeige SMAD3 Antikörper) and facilitates their dephosphorylation by PPM1A (zeige PPM1A Antikörper).

  6. The absence of direct binding of BAF (zeige BANF1 Antikörper) to MAN1-C eliminates disruption of this interaction as the cause of the premature aging phenotype.

  7. Genetic analyses of three generations of a family with Buschke-Ollendorff syndrome having a variable phenotype showed a novel c.2203C>T nonsense mutation at the LEMD3 locus. The mutation induced a change in the 735 arginine codon to a stop codon.

  8. Buschke-Ollendorff syndrome in a three-generation family: influence of a novel LEMD3 mutation to tropoelastin (zeige ELN Antikörper) expression.

  9. We found a novel c.2203C > T (p.R735X) mutation in exon 9 of LEMD3, resulting in a premature stop codon at amino acid position 735.

  10. Absence of LEMD3 mutation in the exons and splice sites of a family with BOS suggests that there is genetic heterogeneity for this disorder.

Mouse (Murine) LEM Domain Containing 3 (LEMD3) Interaktionspartner

  1. a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 Antikörper) signaling in which MAN1 competes with transcription factors for binding to Smad2 (zeige SMAD2 Antikörper) and Smad3 (zeige SMAD3 Antikörper) and facilitates their dephosphorylation by PPM1A (zeige PPM1A Antikörper).

  2. the heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome.

  3. In Man1-deficient embryos, the expression of Tgfb1 (zeige TGFB1 Antikörper) is upregulated and Smad2 (zeige SMAD2 Antikörper)/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis.

  4. The nuclear envelope protein (zeige SUN2 Antikörper) MAN1 regulates TGFbeta (zeige TGFB1 Antikörper) signaling and vasculogenesis in the embryonic yolk sac (zeige ADCY10 Antikörper).

  5. Man1 regulates left-right asymmetry by controlling Nodal signaling in a node-independent manner

Pig (Porcine) LEM Domain Containing 3 (LEMD3) Interaktionspartner

  1. Genome-wide analysis combined with linkage results revealed LEMD3 and WIF1 (zeige WIF1 Antikörper) as the candidates for porcine ear size.

Xenopus laevis LEM Domain Containing 3 (LEMD3) Interaktionspartner

  1. LEM proteins, involved in signalling essential for organ development during early embryogenesis and suggests that loss of MAN1 may cause muscle and retina specific diseases

LEM Domain Containing 3 (LEMD3) Antigen-Profil

Protein Überblick

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Genbezeichner und Symbole assoziert mit LEMD3

  • LEM domain containing 3 (LEMD3) Antikörper
  • LEM domain containing 3 (Lemd3) Antikörper
  • LEM domain containing 3 (lemd3) Antikörper
  • LEM domain containing 3 S homeolog (lemd3.S) Antikörper
  • AI316861 Antikörper
  • im:7158446 Antikörper
  • lemd3 Antikörper
  • man1 Antikörper
  • RGD1561001 Antikörper
  • sane Antikörper
  • si:dkey-6a5.6 Antikörper
  • wu:fb34b12 Antikörper
  • xman1 Antikörper

Bezeichner auf Proteinebene für LEMD3

LEM domain-containing protein 3 , inner nuclear membrane protein Man1 , integral inner nuclear membrane protein , integral inner nuclear membrane protein MAN1 , LEM domain containing 3 , Smad1 antagonistic effector , LEM domain containing 3 S homeolog , nuclear membrane protein XMAN1

GENE ID SPEZIES
23592 Homo sapiens
380664 Mus musculus
417832 Gallus gallus
452050 Pan troglodytes
530659 Bos taurus
558474 Danio rerio
608380 Canis lupus familiaris
680066 Rattus norvegicus
717597 Macaca mulatta
100038042 Xenopus (Silurana) tropicalis
100079476 Ornithorhynchus anatinus
100346960 Oryctolagus cuniculus
100402143 Callithrix jacchus
100441107 Pongo abelii
100511508 Sus scrofa
100553511 Anolis carolinensis
398582 Xenopus laevis
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