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This locus encodes a LEM domain-containing protein. Zusätzlich bieten wir Ihnen LEM Domain Containing 3 Proteine (3) und LEM Domain Containing 3 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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studies demonstrated that lower levels of MAN1 in differentiating MSC (zeige MSC Antikörper) are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis.
We used The Cancer Genome Atlas breast cancer patient data to identify ANKLE1 and ZNF404 as the target genes of candidate TF binding site SNPs in the 19p13.11 and 19q13.31 GWAS-identified loci. These SNPs are associated with the expression of ZNF404 and ANKLE1 in breast tissue.
the domains mediating nuclear import and export of Ankle1, were identified.
Expression of RCCD1 in whole blood was also suggestively associated with disease risk (p-value: 1.2x10-05), as were expression of ACAP1 (p-value: 1.9x10-05) and LRRC25 (p-value: 5.2x10-05). While genome-wide association studies (GWAS) have implicated RCCD1 and ANKLE1 in breast cancer risk, they have not identified the remaining three genes
Letter/Case-Report: novel frameshift mutation in RNA recognition motif of LEMD3 in patient with Buschke-Ollendorff syndrome.
A novel mutation in LEMD3 splice site results in Buschke-Ollendorff syndrome.
Data indicate that the inner nuclear membrane protein MAN1 directly binds the transcription activator BMAL1 (zeige ARNTL Antikörper) promoter and enhances its transcription.
a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 Antikörper) signaling in which MAN1 competes with transcription factors for binding to Smad2 (zeige SMAD2 Antikörper) and Smad3 (zeige SMAD3 Antikörper) and facilitates their dephosphorylation by PPM1A (zeige PPM1A Antikörper).
Ankle1 is conserved in metazoans and contains a unique C-terminal GIY-YIG motif that confers endonuclease activity in vitro and in vivo
The absence of direct binding of BAF (zeige BANF1 Antikörper) to MAN1-C eliminates disruption of this interaction as the cause of the premature aging phenotype.
the heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome.
In Man1-deficient embryos, the expression of Tgfb1 (zeige TGFB1 Antikörper) is upregulated and Smad2 (zeige SMAD2 Antikörper)/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis.
The nuclear envelope protein (zeige SUN2 Antikörper) MAN1 regulates TGFbeta (zeige TGFB1 Antikörper) signaling and vasculogenesis in the embryonic yolk sac (zeige ADCY10 Antikörper).
Man1 regulates left-right asymmetry by controlling Nodal signaling in a node-independent manner
Genome-wide analysis combined with linkage results revealed LEMD3 and WIF1 (zeige WIF1 Antikörper) as the candidates for porcine ear size.
LEM proteins, involved in signalling essential for organ development during early embryogenesis and suggests that loss of MAN1 may cause muscle and retina specific diseases
This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.
LEM domain-containing protein 3
, inner nuclear membrane protein Man1
, integral inner nuclear membrane protein
, integral inner nuclear membrane protein MAN1
, LEM domain containing 3
, Smad1 antagonistic effector
, LEM domain containing 3 S homeolog
, nuclear membrane protein XMAN1