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KLF14 encodes a member of the Kruppel-like family of transcription factors. Zusätzlich bieten wir Ihnen KLF14 Antikörper (27) und KLF14 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.
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SNPs at the CETP (zeige CETP Proteine), HNF4A (zeige HNF4A Proteine) and KLF14 (zeige SP6 Proteine) locus are associated with HDL (zeige HSD11B1 Proteine)-C levels and type 2 diabetes (in female participants).
KLF14 (zeige SP6 Proteine) plays an important role in increasing glucose uptake and insulin (zeige INS Proteine) sensitivity by the activation of PI3-kinase (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway in vitro.
KLF14 (zeige SP6 Proteine) transcription is significantly downregulated, whereas Plk4 transcription is upregulated in multiple types of cancers, and there exis (zeige SP6 Proteine)ts an inverse correlation between KLF14 and Plk4 protein expression in human breast and colon cancers.
Trans (zeige SP6 Proteine)duction of HepG2 cells with human KLF14 showed that KLF14 is a regu (zeige SP6 Proteine)lator of APOA1 expres (zeige HSD11B1 Proteine)sion.
The risk allele C of rs151290 in KCNQ1 (zeige KCNQ1 Proteine) and risk allele G of rs972283 in KLF14 (zeige SP6 Proteine) were both associated with increased risk of T2DM in a global population.
This is the first description of the activity and mechanisms underlying the function of KLF14 (zeige SP6 Proteine) as an activator protein and novel regulator of lipid signaling.
The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations.
we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis (zeige CISH Proteine)-acting expression quantitative trait locus (eQTL (zeige EQTN Proteine)) of the maternally expressed transcription factor KLF14 (zeige SP6 Proteine) acts as a master trans regulator of adipose gene expression
KLF14 (zeige SP6 Proteine) gene is imprinted, with preferential expression from the maternal allele.
the TGFbeta (zeige TGFB1 Proteine) pathway activation leads to recruitment of a KLF14 (zeige SP6 Proteine)-mSin3A-HDAC2 (zeige HDAC2 Proteine) repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing.
these data provide proof of concept that deregulation of KLF14 (zeige SP6 Proteine)/PLK1 cascade plays a key role in thrombin (zeige F2 Proteine)-induced endothelial dysfunction in type 2 diabetes mellitus
DNA methylation (zeige HELLS Proteine) at Klf14 (zeige SP6 Proteine) regulated mRNA expressions, which were downstream and inflammation genes in the adipose tissue. The methylation level of KLF14 (zeige SP6 Proteine) supposed to predict inflammatory change in the adipose tissue as epigenetic biomarker in the whole blood.
Klf14 (zeige SP6 Proteine) is not expressed in adult liver and its deletion does not affect plasma HDL (zeige HSD11B1 Proteine)-cholesterol concentration and other diet-induced obesity phenotypes in male mice. Klf14 (zeige SP6 Proteine) is highly expressed in mouse adenohypophysis and KLF14 (zeige SP6 Proteine) loss of function impacts on the pituitary transcriptome.
These data demonstrate an important role for KLF14 (zeige SP6 Proteine) expression in atherosclerotic lesion formation.
KLF14 (zeige SP6 Proteine) reduction serves as a mechanism leading to centrosome amplification and tumorigenesis. On the other hand, forced expression of KLF14 (zeige SP6 Proteine) leads to mitotic catastrophe.
KLF14 (zeige SP6 Proteine) is dysregulated in the liver of 2 dyslipidemia mouse models. KLF14 (zeige SP6 Proteine) regulates plasma HDL (zeige HSD11B1 Proteine)-C levels and cholesterol efflux capacity by modulating hepatic ApoA-I (zeige APOA1 Proteine) production. Hepatic-specific Klf14 (zeige SP6 Proteine) deletion in mice decreased circulating HDL (zeige HSD11B1 Proteine)-C levels.
The presence of progesterone induced the gene expression of egr-1 (zeige EGR1 Proteine) and also KLF14 (zeige SP6 Proteine), indicating that this steroid channels the signaling pathway into a non-canonical mechanism.
KLF14 (zeige SP6 Proteine) gene is intronless, and is monoallelically expressed from the maternal allele in both human and mouse.
This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.
BTE-binding protein 5
, Krueppel-like factor 14
, basic transcription element-binding protein 5
, transcription factor BTEB5
, LOW QUALITY PROTEIN: Krueppel-like factor 14