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The protein encoded by KIF23 is a member of kinesin-like protein family. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal KIF23 Primary Antibody für ICC, IF - ABIN151546
Soares, Battistella, Rocca, Matuo, Henriques, Larsen, Escargueil: Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. in The Biochemical journal 2011
Cow (Bovine) Polyclonal KIF23 Primary Antibody für WB - ABIN2778207
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
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Cow (Bovine) Polyclonal KIF23 Primary Antibody für WB - ABIN2778208
Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ... in Genome research 2006
Show all 2 Pubmed References
Authors found that KIF23 was regulated by TCF-4 (zeige TCF4 Antikörper) at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma.
Data show high level of KIF23 expression in the majority of primary and metastatic lung cancer tissues or cell lines and associates with poor survival.
In this study we show for the first time that KIF23 V1 and V2 have different localizations in hepatocellular carcinoma cells
Phosphorylation of S716 NDR (zeige STK38 Antikörper)/LATS (zeige LATS1 Antikörper), present only in the longest Kif23 isoform, is required for phosphorylation at S814, revealing phosphorylation at these two sites, and differential regulation of Kif23-14-3-3 (zeige YWHAQ Antikörper) interaction for the two Kif23 isoforms.
TRAF6 (zeige TRAF6 Antikörper) mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1.
Transcriptional regulation of KIF23 is mediated by TP53 (zeige TP53 Antikörper).
KIF23 mutation is associated with congenital dyserythropoietic anemia type III.
v-Src (zeige SRC Antikörper) inhibits cytokinesis through the delocalization of Mklp1 and Aurora B (zeige AURKB Antikörper) from the spindle midzone, resulting in binucleation.
It was shown that, during cytokinesis, Arf6 (zeige ARF6 Antikörper) is first accumulated around the cleavage furrow and, prior to abscission, recruited onto the Flemming body via interaction with MKLP1.
The results of this study indicated that downregulation of KIF23 decreases proliferation of glioma cells and that KIF23 may be a novel therapeutic target in malignant glioma.
depletion of KIF23 inhibited lung tumor formation in vivo, similar to what is seen with deletion of MMB (zeige DYRK1A Antikörper). In vitro, the depletion of KIF23 in lung cancer cell lines showed strong anti-proliferative activity, which was accompanied by apoptosis in a subset of cell lines.
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms.
kinesin family member 23
, kinesin-like protein KIF23
, kinesin-like protein KIF23-like
, kinesin-like 5 (mitotic kinesin-like protein 1)
, kinesin-like 5
, mitotic kinesin-like protein 1