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mouse homolog associates with microtubulew and appears to play a role in mitosis in fibroblasts and in migration in developing neurons [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen KIF15 Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.
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KIF15 knockdown using short hairpin RNA in two human lung adenocarcinoma cell lines induced G1/S phase cell cycle arrest and inhibited cell growth.
The non-motor microtubule-binding tail domain interacts with the microtubule's E-hook tail with a rupture force higher than the stall force of the motor. This allows Kif15 dimers to productively and efficiently generate forces that could potentially slide microtubules apart.
Both Kif15 and KBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length.
This study identified KIF15 as a critical regulator that promotes pancreatic cancer proliferation, broadening our understanding of KIF15 function in tumorigenesis.
To our knowledge, KIF15 is the first kinesin to be associated with congenital thrombocytopenia.
KIF15 is involved in alternative spindle assembly pathways.
When intersecting microtubules are parallel, Kif15 motors can drive (biased) parallel sliding because the motor simultaneously steps on both microtubules that it cross-links.
These data reveal that hKif15 is a plus-end-directed processive homotetramer that can step against loads of up to 3.5 pN.
Eg5, Kif15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation.
regulates alpha2 integrin internalization
Although Kif15 contains ADP in the catalytic site, its motor-domain structure was captured in the ;ATP-like' configuration, with the neck linker docked to the catalytic core.
By examining Kif15 activity in two cellular contexts, it was found that Kif15 bound to kinetochore fibers antagonizes centrosome separation while Kif15 bound to nonkinetochore MTs mediates centrosome separation.
Pole separation depends on Hklp2/Kif15, an otherwise dispensable plus end-directed spindle motor and results in spindles with two centrosomal poles.
Kif15 can replace all essential functions of Eg5 in bipolar spindle assembly.
Hklp2 participates in the assembly and stabilization of the bipolar spindle.
mouse homolog associates with microtubulew and appears to play a role in mitosis in fibroblasts and in migration in developing neurons
kinesin-like protein 2-A
, kinesin-like protein KIF15-A
, kinesin family member 15
, kinesin-like protein KIF15-B
, kinesin-like protein 2-B
, kinesin-like protein KIF15-like
, kinesin-like 7
, kinesin-like protein 2
, kinesin-like protein 7
, kinesin-like protein KIF15
, serologically defined breast cancer antigen NY-BR-62
, N-10 kinesin
, kinesin 15