anti-Kinase Suppressor of Ras 1 (KSR1) Antikörper

Location-regulated scaffolding protein connecting MEK to RAF. Zusätzlich bieten wir Ihnen Kinase Suppressor of Ras 1 Kits (10) und Kinase Suppressor of Ras 1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KSR1 16706 Q61097
KSR1 360573  
KSR1 8844 Q8IVT5
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Top anti-Kinase Suppressor of Ras 1 Antikörper auf antikoerper-online.de

Showing 10 out of 123 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IC, IF, IHC, WB   200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, treated with PDGF 50ng/ml 20', using KSR (Ab-392) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KSR (Ab-392) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells, using KSR (Phospho-Ser392) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using KSR (Phospho-Ser392) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Maus Kaninchen Unkonjugiert WB Mouse Ksr1 Antibody (C-term) (ABIN658071) western blot analysis in mouse NIH-3T3 cell line lysates (35 µg/lane). This demonstrates the Ksr1 antibody detected the Ksr1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert IHC, WB ABIN6267132 at 1/100 staining Human thyroid cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of HEK293 cells, using Phospho-KSR1 (Ser392/406) Antibody. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of Phospho-KSR1 (Ser569) in lysates of HepG2, using Phospho-KSR1 (Ser569) Antibody(ABIN6270247). 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$450.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of Phospho-KSR1(Thr425) in lysates of HepG2, using Phospho-KSR1(Thr425) Antibody(ABIN6267891). 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$450.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$493.17
Details

Am meisten referenzierte anti-Kinase Suppressor of Ras 1 Antikörper

  1. Human Polyclonal KSR1 Primary Antibody für IHC (p), ELISA - ABIN544441 : Jhiang: The RET proto-oncogene in human cancers. in Oncogene 2000 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen Kinase Suppressor of Ras 1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Kinase Suppressor of Ras 1 (KSR1) Interaktionspartner

  1. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.

  2. KSR is a scaffold required for activation of the ERK/MAPK module.

  3. Review discusses the possibility that KSR, a RAF-like protein, does not solely act as a scaffold, but directly induces RAF catalytic function by a kinase-independent mechanism apparently shared by RAF-like proteins.

Mouse (Murine) Kinase Suppressor of Ras 1 (KSR1) Interaktionspartner

  1. DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF.

  2. praja2 regulates KSR1 stability and mitogenic signaling.

  3. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.

  4. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  5. propose that phosphorylation of Tyr(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses

  6. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1.

  7. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation.

  8. Ksr1 plays a dispensable role in lipopolysaccharide (LPS)-induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model.

  9. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.

  10. The loss of Ksr1 inhibits Ras/Mapk pathway signaling leading to increased Myc-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.

  11. a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1

  12. Genetic disruption of KSR1 results in striking reductions in kit-ligand-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase.

  13. Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability.

  14. findings suggest that Ksr1 functions as a previously unknown scaffold that enhances iNOS activity and is therefore crucial for the pulmonary response to P. aeruginosa infections

  15. KSR1 is a functional protein kinase, MEK1 is an in vitro substrate of KSR1, and the catalytic activities of both proteins are required for eliciting cell survival responses downstream of TNF.

  16. Mice lacking both KSR1 and IL-10 develop exacerbated colitis due to dysregulated IFN-gamma production in T lymphocytes.

  17. despite a requirement for KSR1 for full ERK activation in thymocytes, full and efficient ERK activation is not essential for the majority of thymocyte selection events.

  18. Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor.

  19. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

  20. evidence for interaction of Nm23-H1 and the suppressor of kinase Ras(KSR)in mammalian cells; can phosphorylate KSR via a histidine-dependent pathway

Human Kinase Suppressor of Ras 1 (KSR1) Interaktionspartner

  1. findings demonstrate that KSR-MEK complexes allosterically activate BRAF through the action of N-terminal regulatory region and kinase domain contacts and challenge the accepted role of KSR as a scaffold for MEK recruitment to RAF

  2. Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

  3. praja2 regulates KSR1 stability and mitogenic signaling.

  4. Data show that neurofibromin 2 (Merlin) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1) and DCAF1 protein.

  5. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.

  6. Upregulation of KSR1 is associated with Colorectal cancer.

  7. the relative mRNA copy values of KSR1, ERK1 and ERK2 in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer

  8. KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha+ BC treated with adjuvant TAM.

  9. KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in papillary thyroid cancer.

  10. KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 abundance and increased BRCA1-BARD1 interaction

  11. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  12. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1.

  13. Our findings integrate KSR1 into a network involving DBC1 and SIRT1, which results in the regulation of p53 acetylation and its transcriptional activity.

  14. Elevated levels of phosphorylated KSR were detected in the nuclear fractions.

  15. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.

  16. VRK2A can form a high molecular size complex with both MEK1 and KSR1; the KSR1 complex assembled and retained by VRK2A in the endoplasmic reticulum can have a modulatory effect on the signal mediated by MAPK,locally affecting the magnitude of its responses

  17. simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1

  18. Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.

  19. KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels

  20. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.

Kinase Suppressor of Ras 1 (KSR1) Antigen-Profil

Protein Überblick

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Genbezeichner und Symbole assoziert mit KSR1

  • kinase suppressor of ras 1 (KSR1) Antikörper
  • kinase suppressor of ras (ksr) Antikörper
  • kinase suppressor of ras 1 (Ksr1) Antikörper
  • AW492498 Antikörper
  • B-KSR1 Antikörper
  • CG2899 Antikörper
  • D11Bhm183e Antikörper
  • D11Bhm184e Antikörper
  • dKsr Antikörper
  • Dmel\\CG2899 Antikörper
  • EK3-1 Antikörper
  • hb Antikörper
  • Ksr Antikörper
  • Ksr-1 Antikörper
  • l(3)j5E2 Antikörper
  • RSU2 Antikörper
  • SR3-1 Antikörper

Bezeichner auf Proteinebene für KSR1

CG2899-PA , kinase suppressor of Ras85D , ksr-PA , suppressor of Ras1 3-1 , kinase suppressor of Ras 1 , mKSR1 , protein Hb

GENE ID SPEZIES
100071912 Equus caballus
40660 Drosophila melanogaster
16706 Mus musculus
360573 Rattus norvegicus
8844 Homo sapiens
427839 Gallus gallus
610451 Canis lupus familiaris
100511282 Sus scrofa
100138565 Bos taurus
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