Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Location-regulated scaffolding protein connecting MEK to RAF.
Showing 10 out of 109 products:
the atypical C1 domain, the CC-SAM (zeige TTN Antikörper) domain is required to target KSR-1 to the plasma membrane.
KSR is a scaffold required for activation of the ERK/MAPK (zeige MAPK1 Antikörper) module.
Review discusses the possibility that KSR, a RAF (zeige ARAF Antikörper)-like protein, does not solely act as a scaffold, but directly induces RAF (zeige RAF1 Antikörper) catalytic function by a kinase-independent mechanism apparently shared by RAF (zeige RAF1 Antikörper)-like proteins.
DiRas3 (zeige DIRAS3 Antikörper) binds to KSR1 independently of its interaction with activated Ras and RAF (zeige RAF1 Antikörper).
praja2 (zeige PJA2 Antikörper) regulates KSR1 stability and mitogenic signaling.
These results suggest that Rap1 (zeige TERF2IP Antikörper) activation of ERKs requires PKA phosphorylation and KSR binding.
Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.
propose that phosphorylation of Tyr (zeige TYR Antikörper)(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses
Data indicate that phosphorylation of BRAF (zeige BRAF Antikörper) by AMPK (zeige PRKAA1 Antikörper) disrupts its association with KSR1.
Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR (zeige FRAP1 Antikörper)-dependent T cell differentiation.
Ksr1 plays a dispensable role in lipopolysaccharide (LPS (zeige TLR4 Antikörper))-induced ERK (zeige EPHB2 Antikörper) activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS (zeige TLR4 Antikörper) model.
The loss of Ksr1 inhibits Ras/Mapk (zeige MAPK1 Antikörper) pathway signaling leading to increased Myc (zeige MYC Antikörper)-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.
Data show that neurofibromin 2 (Merlin (zeige NF2 Antikörper)) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1) and DCAF1 (zeige VPRBP Antikörper) protein.
These results suggest that Rap1 (zeige RABGEF1 Antikörper) activation of ERKs requires PKA phosphorylation and KSR binding.
Upregulation of KSR1 is associated with Colorectal cancer.
the relative mRNA copy values of KSR1, ERK1 and ERK2 in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer
KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha (zeige ESR1 Antikörper)+ BC treated with adjuvant TAM (zeige CCNA1 Antikörper).
KSR1 is coordinately regulated with Notch (zeige NOTCH1 Antikörper) signaling and oxidative phosphorylation in papillary thyroid cancer.
KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 (zeige BARD1 Antikörper) abundance and increased BRCA1-BARD1 (zeige BARD1 Antikörper) interaction
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
, kinase suppressor of Ras85D
, suppressor of Ras1 3-1
, kinase suppressor of Ras 1
, protein Hb