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Receptor on natural killer (NK) cells for class I MHC..
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Mouse (Murine) Monoclonal Klra4 Primary Antibody für BR, FACS - ABIN2689815
Hanke, Takizawa, McMahon, Busch, Pamer, Miller, Altman, Liu, Cado, Lemonnier, Bjorkman, Raulet: Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. in Immunity 1999
this study shows that after mouse cytomegalovirus infection, Ly49D augmented IFN-gamma production by virus-specific Ly49H(+) NK cells and preferentially promoted the generation of memory Ly49H(+) NK cells
The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
The Ly49D activation receptor on mouse NK cells specifically recognizes the Chinese hamster histocompatibility class I molecule associated with Chinese hamster beta 2-microglobulin (zeige B2M Antikörper) (beta 2m) and is not tolerized in murine beta 2m deficiency.
Activating Ly49D NK cell receptors are provided a mechanism for release from inhibitory receptor blockade that enables them to become important initiators of microbial, antiviral, and antitumor immunity.
Coexpression of a Ly49A transgene partially rescued NKT (zeige CTSL1 Antikörper) cell development in Ly49D/H2-Dd transgenics.
Glycosylation of Ly-49D at amino acid residues NTT221-23 reduces receptor binding to H-2Dd (zeige DHDH Antikörper) tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands.
The MHC class I receptor Ly49D expressed on immature B cells recognizes MHC class I on peripheral tissues, inducing secretion of low levels of IFN-gamma (zeige IFNG Antikörper) and thereby down-regulating immature B cell homing to the lymph nodes or to sites of inflammation.
Ly49D stimulation triggers cellular activation of CD4 (zeige CD4 Antikörper) and CD8 (zeige CD8A Antikörper) populations; Ly49D recognizes the classical hamster class I molecule Hm1-C4 on CHO (zeige COL11A1 Antikörper) cells, as demonstrated by the killing of Hm1-C4-transfected thymoma cells by Ly49D cytotoxic T cells.
these data demonstrate that DAP10 (zeige HCST Antikörper) does associate with Ly49H and Ly49D in primary NK cells.
Receptor on natural killer (NK) cells for class I MHC.
T-cell surface glycoprotein Ly-49D
, killer cell lectin-like receptor 4
, killer cell lectin-like receptor subfamily A member 32
, lymphocyte antigen 49d