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JAZF1 encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Zusätzlich bieten wir Ihnen JAZF Zinc Finger 1 Proteine (5) und JAZF Zinc Finger 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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PNPLA3 (zeige PNPLA3 Antikörper) and JAZF1 were associated with non-hepatitis B virus and non-hepatitis C virus-related hepatocellular carcinoma development among Japanese patients with type 2 diabetes mellitus
study found SNP rs7754840 in CDKAL1 (zeige CDKAL1 Antikörper), rs864745 in JAZF1, and rs35767 in IGF1 (zeige IGF1 Antikörper) might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population
genetic association study in Han population in China: Data suggest an SNP in PXK (zeige PXK Antikörper) [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L (zeige KIAA0319L Antikörper) [rs2275247(A/G)] or JAZF1 [rs1635852(C/T)] are not associated.
In African American men, the association between JAZF1 rs10486567 and prostate cancer may be modified by exposure to heavy metals such as Pb.
study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (zeige PXK Antikörper) (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis
Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 and PHF1 (zeige PHF1 Antikörper) genes were correlated with tumor category and outcome in endometrial sarcomas
genetic association studies in a population in Utah: Data suggest that an SNP in JAZF1 (rs1635852) is associated with type 2 diabetes; this SNP in JAZF1 intron 1 is part of a cis (zeige CISH Antikörper)-regulatory complex.
This study indicates a nominal role for JAZF1 and BCL11A (zeige BCL11A Antikörper) variants in type 2 diabetes susceptibility in African-Americans.
Single-nucleotide polymorphism of rs10486567 in JAZF1 is associated with prostate cancer.
The JAZF1 SNPs rs6968704 and rs10486567 were associated with decreased risk of prostate cancer but were not associated with diabetes.
TIP27 has an important role in glucose homeostasis through the regulation of hepatic glucose metabolism and insulin (zeige INS Antikörper) sensitivity. Furthermore, this regulation requires activation of PI3-kinase (zeige PIK3CA Antikörper).
aberrant JAZF1 expression contributes to the oncogenesis and type 2 diabetes pathogenesis
JAZF1 overexpression decreased serum cholesterol levels and hepatic cholesterol synthesis by inhibiting CREB (zeige CREB1 Antikörper)-dependent HMGCR (zeige HMGCR Antikörper) promoter transcriptional activity.
JAZF1 plays an important role in lipid metabolism and may thus provide a potential tool for the treatment of obesity and lipid metabolism disorders among other diseases
JAZF1 was significantly upregulated during the differentiation of 3T3-L1 preadipocytes. The overexpression of JAZF1 inhibited lipid accumulation in differentiated mature 3T3-L1 adipocytes.
results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes
Jazf1 overexpression may induce heart failure symptoms through the upregulation of pro-apoptotic genes in cardiomyocytes.
These results showed that JAZF1 in adipocytes and liver cells reduces lipid synthesis and increases lipolysis
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized
JAZF zinc finger 1
, juxtaposed with another zinc finger gene 1
, juxtaposed with another zinc finger protein 1
, TAK1-interacting protein 27
, zinc finger protein 802