Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) ELISA Kits

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH2 Antikörper (113) und IDH2 Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top IDH2 ELISA Kits auf antikoerper-online.de

Showing 5 out of 14 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.074 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$589.47
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Maus
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Ratte
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
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Schwein
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
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Weitere ELISA Kits für IDH2 Interaktionspartner

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. TET2 (zeige TET2 ELISA Kits), ASXL1 (zeige ASXL1 ELISA Kits), IDH1 (zeige IDH1 ELISA Kits), and IDH2 Single Nucleotide Polymorphisms in Turkish Patients with Chronic Myeloproliferative Neoplasms.

  2. IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5'-diphosphate-ribose) polymerase inhibitors

  3. To confirm this result, we analyzed survival data from 142 LGGs from TCGA with IDH1 (zeige IDH1 ELISA Kits)/IDH2 mutations and no 1p19q codeletion. Despite the high rate of censured data, we found that CNLOH 17p, including the TP53 (zeige TP53 ELISA Kits) locus, was associated with better outcome (OR = 0.27; p = .026)

  4. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (zeige IDH1 ELISA Kits)/IDH2, ATRX (zeige ATRX ELISA Kits), and 1p/19q results.

  5. In this review, we focus on three key areas in acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)) developmental therapeutics: FLT3 (zeige FLT3 ELISA Kits) inhibitors, IDH(IDH1 (zeige IDH1 ELISA Kits) and IDH2 ) inhibitors, and drugs that may be particularly beneficial in secondary AML (zeige RUNX1 ELISA Kits)

  6. The role of mutant IDH1 (zeige IDH1 ELISA Kits) and IDH2 inhibitors in the treatment of acute myeloid leukemia (zeige BCL11A ELISA Kits).

  7. olaparib and other PARP (zeige COL11A2 ELISA Kits) inhibitors killed cells in multiple cancer cell lines that harbor IDH1 (zeige IDH1 ELISA Kits) and IDH2 mutations. In addition, glioma cell lines generated from patient tumors with IDH1 (zeige IDH1 ELISA Kits) mutations were vulnerable to the investigational PARP (zeige COL11A2 ELISA Kits) inhibitor talazoparib . In mice, olaparib slowed the growth of implanted IDH1 (zeige IDH1 ELISA Kits)-mutant tumors.

  8. demonstrate the presence of the IDH2 p.R172K/S mutation in patients with cutaneous localizations of angioimmunoblastic T-cell lymphomas.

  9. an IDH mutant-enriched subtype of cholangiocarcinoma with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number, is reported.

  10. IDH (zeige IDH1 ELISA Kits) mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm ICC cells are hypersensitive to dasatinib and critically dependent on SRC (zeige SRC ELISA Kits) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase (zeige alphaKGDHC ELISA Kits) and induces histone modifications in an ACL (zeige APOC4 ELISA Kits)-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart

  2. Increased obesity resistance and insulin (zeige INS ELISA Kits) sensitivity in mice lacking the IDH2 gene has been documented.

  3. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (zeige SOD2 ELISA Kits) expression, eNOS (zeige NOS3 ELISA Kits) phosphorylation and NO production in endothelial cells

  4. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  5. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  6. IDH2 and NPM1 (zeige GJA1 ELISA Kits) mutations synergize in the development and maintenance of acute myeloid leukemia (zeige BCL11A ELISA Kits) stem-like cells.

  7. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  8. These data demonstrate the proto-oncogenic role of mutant IDH2.

  9. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  10. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (zeige HIF1A ELISA Kits) expression, blunted mRNA expression of HIF-1alpha (zeige HIF1A ELISA Kits), VEGF (zeige VEGFA ELISA Kits), and the glucose transport protein Glut-1 (zeige SLC1A3 ELISA Kits) was also observed.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. The enzyme is highly sensitive to Mg(2 (zeige MCOLN1 ELISA Kits)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (zeige MCOLN1 ELISA Kits)+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B ELISA Kits)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B ELISA Kits)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 ELISA Kits) activity.

IDH2 Antigen-Profil

Beschreibung des Gens

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Genbezeichner und Symbole assoziert mit IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2) Antikörper
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) Antikörper
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2) Antikörper
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2) Antikörper
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S) Antikörper
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2) Antikörper
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867) Antikörper
  • D2HGA2 Antikörper
  • E430004F23 Antikörper
  • F6P23.14 Antikörper
  • F6P23_14 Antikörper
  • ICD-M Antikörper
  • IDH Antikörper
  • Idh-2 Antikörper
  • IDH-II Antikörper
  • IDH2 Antikörper
  • IDHM Antikörper
  • IDP Antikörper
  • IDPm Antikörper
  • isocitrate dehydrogenase II Antikörper
  • isocitrate dehydrogenase subunit 2 Antikörper
  • mNADP-IDH Antikörper
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 Antikörper
  • wu:fb33c06 Antikörper
  • wu:fk31e05 Antikörper
  • wu:fq43b01 Antikörper
  • zgc:55485 Antikörper

Bezeichner auf Proteinebene für IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

GENE ID SPEZIES
816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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