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The protein encoded by IL31RA belongs to the type I cytokine receptor family. Zusätzlich bieten wir Ihnen Interleukin 31 Receptor A Antikörper (52) und Interleukin 31 Receptor A Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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The first demonstration of the involvement of the IL-31 (zeige IL31 Proteine)/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31 (zeige IL31 Proteine), whose serum levels correlated with pruritus intensity.
The interleukin IL-31 (zeige IL31 Proteine)/IL-31receptor axis contributes to tumor growth in human follicular lymphoma.
IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1 (zeige TRPV1 Proteine)(+)/TRPA1 (zeige TRPA1 Proteine)(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch.
IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells.
IFN-gamma-induced (zeige SAMHD1 Proteine) IL-31RA upregulation in dermal microvascular endothelium is processed via JNK (zeige MAPK8 Proteine) and PI3 kinase (zeige PIK3CA Proteine) activation
The identification of OSMR (zeige OSMR Proteine) and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology.
A novel type I cytokine receptor (zeige EBI3 Proteine) is expressed on monocytes, signals proliferation, and activates STAT-3 (zeige STAT3 Proteine) and STAT-5 (zeige STAT5A Proteine).
GPL is a novel cytokine receptor (zeige EBI3 Proteine) related to GP130 (zeige IL6ST Proteine) and leukemia inhibitory factor receptor (zeige LIFR Proteine)
the molecular mechanisms underlying GPL-mediated signal transduction
IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma (zeige IFNG Proteine)
IL-31 (zeige IL31 Proteine) upregulates IL-31RA expression in DRG neuron cell bodies, and cutaneous-injected IL-31 (zeige IL31 Proteine)-induced itching is enhanced by DRG IL-31RA expression in mice
Anti-IL-31 (zeige IL31 Proteine) receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice
Gp130 (zeige LRPPRC Proteine)(757F/F) mice rapidly develop distal stomach tumors, with loss of SHP2 (zeige PTPN11 Proteine)/Erk (zeige EPHB2 Proteine)/AP-1 (zeige JUN Proteine) transcriptional regulation exemplified by decreased TFF1 (zeige TFF1 Proteine) expression and increased STAT1 (zeige STAT1 Proteine)/3 regulated genes such as Reg (zeige KCNH2 Proteine) I.
IL-31 receptor alpha signaling is a novel negative regulatory pathway that specifically limits T helper cell type 2 inflammation.
these data provide the first evidence of a function for IL-31 (zeige IL31 Proteine)-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
interleukin 31 receptor A
, gp130-like monocyte receptor
, IL-31 receptor subunit alpha
, IL-31R subunit alpha
, class I cytokine receptor
, cytokine receptor-like 3
, interleukin-31 receptor subunit alpha
, soluble type I cytokine receptor CRL3
, cytokine receptor NR10
, gp130-like receptor
, interleukin 31RA
, novel cytokine receptor 10