Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
IFIT2 encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Zusätzlich bieten wir Ihnen Interferon-Induced Protein with Tetratricopeptide Repeats 2 Antikörper (71) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 5 out of 5 products:
The results of the present study revealed that the inhibition of proteasome activity blocked the degradation of IFIT2 and promoted the aggregation of IFIT2 in the centrosome, which in turn induced cell apoptosis. In short, IFIT2 may be a potential target for cancer therapeutics.
Mechanistic investigations reveal that AJUBA (zeige AJUBA Proteine) specifically binds the FERM domain of JAK1 (zeige JAK1 Proteine) to dissociate JAK1 (zeige JAK1 Proteine) from the IFNgamma recepter, resulting in an inhibition of STAT1 (zeige STAT1 Proteine) phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (zeige AJUBA Proteine) in CRC (zeige CALR Proteine) specimens is negatively correlated with the levels of IFIT2 and pSTAT1
LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR (zeige MLXIP Proteine)-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance.
there is a positive feedback loop between phosphorylated STAT1 and ISG56, ISG54 or ISG60.
Data show that interferon (zeige IFNA Proteine)-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 (zeige IFIT1 Proteine) and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.
Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor.
IFIT2, a protein responsible for interferon (zeige IFNA Proteine) stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker.
ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation.
Inhibitor of kappaB kinase epsilon (IKK(epsilon (zeige IKBKE Proteine))), STAT1 (zeige STAT1 Proteine), and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
The expression of OASL (zeige OASL Proteine) and IFIT2 was significantly higher in SLE patients than in controls.
this study shows that activation of IRF3 (zeige IRF3 Proteine) contributes to IFN-gamma (zeige IFNG Proteine) and ISG54 expression during the immune responses to B16F10 tumor growth
Ifit2 exerts its antiviral effect mainly at the level of viral replication, as opposed to functioning as a mechanism that restricts viral entry/egress or transports rabies virus particles through axons.
the mechanism for the observed differential induction of the mouse Ifit1 (zeige IFIT1 Proteine), Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8 (zeige IRF8 Proteine)), which is highly expressed in B cells, played an essential role in this regulation.
These results indicate that high Sendai virus replication in the lungs of infected Ifit2(-/-) mice cooperates with elevated IFN-beta (zeige IFNB1 Proteine) induction to cause disease.
Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.
Ifit2 is a positive regulator of IFN-alpha (zeige IFNA Proteine)/beta expression during mouse hepatitis virus induced encephalitis.
IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS (zeige TLR4 Proteine))-induced TNF-alpha (zeige TNF Proteine) secretion and LPS (zeige TLR4 Proteine)-induced endotoxin shock.
These results suggest that Ifit2 restricts West Nile virus infection and pathogenesis in different tissues in a cell type-specific manner.
results indicate that in the brain, but not in other organs, Ifit2 is a major mediator of IFN's protective effect against VSV
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.
Interferon, alpha-inducible protein (MW 54kD)
, interferon-induced 54 kDa protein
, interferon-induced protein 54
, interferon-induced protein with tetratricopeptide repeats 2
, glucocorticoid-attenuated response gene 39 protein