Interferon Related Developmental Regulator 1 Proteine (IFRD1)

IFRD1 is an immediate early gene that encodes a protein related to interferon-gamma. Zusätzlich bieten wir Ihnen Interferon Related Developmental Regulator 1 Antikörper (47) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IFRD1 3475 O00458
IFRD1 15982 P19182
IFRD1 29596 P20695
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Wheat germ Human GST tag 2 μg 11 bis 12 Tage
$338.33
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Hefe Ratte His tag   1 mg 60 bis 71 Tage
$3,259.67
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Hefe Wildschwein His tag   1 mg 60 bis 71 Tage
$3,263.33
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IFRD1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Interferon Related Developmental Regulator 1 (IFRD1) Interaktionspartnern

Human Interferon Related Developmental Regulator 1 (IFRD1) Interaktionspartner

  1. Results from a study on gene expression variability markers in early-stage human embryos shows that IFRD1 is a putative marker for the 3-day, 8-cell embryo stage.

  2. High IFRD1 colon cancer expression was significantly associated with decreased 5-year patient survival.

  3. this study shows that IFRD1 gene may be associated with pathogenesis of asthma

  4. rs7817 polymorphism associated with nasal polyposis in cystic fibrosis patients

  5. study reveals an EGFR-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells

  6. rs5009270 may contribute to hip OA susceptibility by altering proximal femur shape.

  7. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta.

  8. Studied the association between IFRD1 polymorphisms and gastric cancer in a Chinese population.

  9. IFRD1 expression is systemically up-regulated in CF neutrophils, is linked to the production of ROS, and is modulated by chemokines in CF airway fluids, depending on the IFRD1 genotype.

  10. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models.

  11. IFRD1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.

  12. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in rat as nerve growth factor-inducible immediate early gene (named PC4).

  13. IFRD1 is an inducer of skeletal muscle regeneration and of satellite cell amplification, by regulating MyoD and NF-kB.

  14. Identification of PC4/IFRD1 as a coactivator of MyoD, a key master gene of muscle development.

  15. In the absence of PC4/IFRD1 skeletal muscle differentiation is defective.

  16. IFRD1 mRNA decay stress-sensitive regulation is mediated by an upstream open reading frame

  17. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes

  18. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity

  19. Sequence conservation, animal models, and protein structure evaluation support the involvement of IFRD1 in SMNA

  20. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7).

Mouse (Murine) Interferon Related Developmental Regulator 1 (IFRD1) Interaktionspartner

  1. Ifrd1 is a critical mediator of both osteoblastogenesis and osteoclastogenesis through its expression in osteoblasts.

  2. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.

  3. adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.

  4. These results suggest that BMP-2 directly induces Ifrd1 expression at the transcriptional level in osteoblasts via the Smad pathway, and Ifrd1 negatively regulates BMP-2-dependent osteoblastogenesis.

  5. Ifrd1 has a pivotal role in bone homeostasis through its expression in osteoblasts in vivo and represents a therapeutic target for bone diseases.

  6. High-fat diet feeding in the setting of tis7 deletion resulted in postresection anastomotic inflammation and small bowel obstruction.

  7. TIS7 predominantly interacted with beta-catenin in the nucleus.

  8. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models.

  9. PC4 plays a role in muscle differentiation by controlling the MyoD pathway through multiple mechanisms, and as such, it positively regulates regenerative myogenesis.

  10. altered postresection adaptive responses of Tis7 knockout mice in short bowel syndrome model; results suggest a novel physiologic function for Tis7 in gut as global regulator of lipid absorption/metabolism and epithelial cell proliferation

  11. TIS7 protein interacts with several proteins of the SIN3 complex (mSin3B, HDAC1, N-CoR and SAP30. TIS7 is a transcriptional co-repressor affecting expression of specific genes in a HDAC-activity-dependent manner during cell fate decisions.

  12. Its expression may be involved in differentiation of neuronal progenitor cells to spiral ganglion cells by the initial sound input.

  13. Results suggest that TIS7 is not essential for mouse development but plays a novel regulatory role during adult muscle regeneration.

  14. TIS7 is a unique mediator of nutrient absorptive and metabolic adaptation following gut resection

  15. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes

  16. TIS7 inhibits CRABP II expression during axonal regeneration, thereby modulating retinoic acid signalling. Hence, neurite initiation and branching are regulated by a negative feedback mechanism involving TIS7 and CRABP II.

  17. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity

  18. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7).

  19. The gene IFRD1/PC4 is required for muscle differentiation. Inhibition of PC4 expression in myoblasts prevents morphological differentiation, impairing myogenin and myosin gene expression. This finding has been confirmed by gene knockout in mice.

Interferon Related Developmental Regulator 1 (IFRD1) Protein Überblick

Protein Überblick

This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit IFRD1

  • interferon-related developmental regulator 1 (ifrd1)
  • interferon related developmental regulator 1 L homeolog (ifrd1.L)
  • interferon related developmental regulator 1 (IFRD1)
  • interferon-related developmental regulator 1 (Ifrd1)
  • Ifnl Protein
  • IFR1 Protein
  • im:7067566 Protein
  • Pc4 Protein
  • si:dkey-192l17.2 Protein
  • Tis7 Protein
  • wu:fi35f04 Protein
  • wu:fj67a06 Protein
  • zgc:154080 Protein

Bezeichner auf Proteinebene für IFRD1

12-O-tetradecanoylphorbol-13-acetate-induced sequence 7 , TPA induced sequence 7 , nerve growth factor-inducible protein PC4 , pheochromocytoma cell-4 , TPA-induced sequence 7 , IRPR

GENE ID SPEZIES
555178 Danio rerio
494857 Xenopus laevis
395226 Gallus gallus
3475 Homo sapiens
482408 Canis lupus familiaris
493185 Sus scrofa
541283 Bos taurus
15982 Mus musculus
29596 Rattus norvegicus
702624 Macaca mulatta
463663 Pan troglodytes
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