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IFRD1 is an immediate early gene that encodes a protein related to interferon-gamma. Zusätzlich bieten wir Ihnen Interferon Related Developmental Regulator 1 Antikörper (30) und viele weitere Produktgruppen zu diesem Protein an.
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High IFRD1 colon cancer expression was significantly associated with decreased 5-year patient survival.
this study shows that IFRD1 gene may be associated with pathogenesis of asthma
rs7817 polymorphism associated with nasal polyposis in cystic fibrosis (zeige S100A8 Proteine) patients
study reveals an EGFR (zeige EGFR Proteine)-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells
PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta.
Studied the association between IFRD1 polymorphisms and gastric cancer in a Chinese population.
IFRD1 expression is systemically up-regulated in CF neutrophils, is linked to the production of ROS (zeige ROS1 Proteine), and is modulated by chemokines in CF airway fluids, depending on the IFRD1 genotype.
This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR (zeige CFTR Proteine) airway epithelial cell models.
IFRD1 is a target gene of the BACH1 (zeige BACH1 Proteine) transcription factor according to ChIP-seq analysis in HEK (zeige EPHA3 Proteine) 293 cells.
This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in rat as nerve growth factor-inducible immediate early (zeige JUN Proteine) gene (named PC4).
adrenergic stimulation induced complex formation between Ifrd1, Sp1 (zeige SP1 Proteine) and mSIN3B, which is a component of the SIN (zeige POLR3E Proteine) complex containing histone deacetylase (zeige HDAC1 Proteine), in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 (zeige SP1 Proteine) and the mSIN3 complex.
These results suggest that BMP-2 (zeige BMP2 Proteine) directly induces Ifrd1 expression at the transcriptional level in osteoblasts via the Smad (zeige SMAD1 Proteine) pathway, and Ifrd1 negatively regulates BMP-2 (zeige BMP2 Proteine)-dependent osteoblastogenesis.
Ifrd1 has a pivotal role in bone homeostasis through its expression in osteoblasts in vivo and represents a therapeutic target for bone diseases.
High-fat diet feeding in the setting of tis7 deletion resulted in postresection anastomotic inflammation and small bowel obstruction.
TIS7 predominantly interacted with beta-catenin (zeige CTNNB1 Proteine) in the nucleus.
PC4 plays a role in muscle differentiation by controlling the MyoD (zeige MYOD1 Proteine) pathway through multiple mechanisms, and as such, it positively regulates regenerative myogenesis.
altered postresection adaptive responses of Tis7 knockout mice in short bowel syndrome model; results suggest a novel physiologic function for Tis7 in gut (zeige GUSB Proteine) as global regulator of lipid absorption/metabolism and epithelial cell proliferation
TIS7 protein interacts with several proteins of the SIN3 complex (mSin3B, HDAC1 (zeige HDAC1 Proteine), N-CoR (zeige NCOR1 Proteine) and SAP30 (zeige SAP30 Proteine). TIS7 is a transcriptional co-repressor affecting expression of specific genes in a HDAC (zeige HDAC3 Proteine)-activity-dependent manner during cell fate decisions.
Results suggest that TIS7 is not essential for mouse development but plays a novel regulatory role during adult muscle regeneration.
This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants.
12-O-tetradecanoylphorbol-13-acetate-induced sequence 7
, TPA induced sequence 7
, nerve growth factor-inducible protein PC4
, pheochromocytoma cell-4
, TPA-induced sequence 7