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ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. Zusätzlich bieten wir Ihnen ITPKC Antikörper (64) und ITPKC Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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The expression of ITPKC in various ciliated tissues suggest a role for the enzyme either in the development or in the function of these specialized cellular structures.
These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka (zeige ITPKA ELISA Kits), Itpkb, Itpkc]
This study identified several important polymorphisms in the ITPKC and SLC11A1 (zeige SLC11A1 ELISA Kits) genes in Koreans.
Genetic variants of ITPKC may have a potential association with HSCR (zeige EDNRB ELISA Kits) (Hirschsprung disease) susceptibility and/or developmental diseases related to enteric nervous system development.
this study shows that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 (zeige NLRP3 ELISA Kits) expression and production of IL-1beta (zeige IL1B ELISA Kits) and IL-18 (zeige IL18 ELISA Kits).
ITPKC polymorphisms are associated with Kawasaki disease.
SNP rs7251246 in ITPKC is associated with the severity of Kawasaki disease
Our results identify a novel polymorphism for renal function and highlight the importance of ITPKC as a key molecule to regulate calcium signaling.
a combinatorial association between ITPKC (rs28493229) and CASP3 (zeige CASP3 ELISA Kits) (rs113420705) was found in coronary artery lesion formation (P = 0.0227, OR: 3.06)in Taiwanese population
functional studies demonstrated that PPP3CC positively influences the protein level of ITPKC, likely by inhibiting phosphorylation of ITPKC and consequently preventing ITPKC from ubiquitin-mediated protein degradation
Functional single-nucleotide polymorphisms in ITPKC and CASP3 (zeige CASP3 ELISA Kits) are associated with susceptibility to Kawasaki's disease (KD).
the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of Kawasaki disease.
This gene encodes a member of the inositol 1,4,5-trisphosphate
inositol-trisphosphate 3-kinase C
, inositol 1,4,5-trisphosphate 3-kinase C
, inositol-trisphosphate 3-kinase C-like
, IP3 3-kinase C
, IP3K C
, insP 3-kinase C
, InsP 3 kinase C