Inositol Polyphosphate-5-Phosphatase, 75kDa Proteine (INPP5B)

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. Zusätzlich bieten wir Ihnen INPP5B Antikörper (45) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
INPP5B 16330 Q8K337
Ratte INPP5B INPP5B 362590  
INPP5B 3633 P32019
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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INPP5B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) Interaktionspartnern

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) Interaktionspartner

  1. These results suggest that the functions of OCRL (zeige OCRL Proteine)/INPP5B and proton-chloride exchange transporter 5 converge on shared mechanisms, the impairment of which has a dramatic effect on proximal tubule endocytosis

  2. study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl (zeige OCRL Proteine) function

  3. ADAM cleavage was only modestly impaired in numerous Inpp5b-null males and varied between individual animals.

  4. These results indicate a functional overlap of Ocrl (zeige OCRL Proteine) and Inpp5b in most cell lineages, especially in extraembryonic tissues.

  5. Inpp5b role in the regulation of cell adhesion in the testis and in the formation of junctional complexes with neighboring cells

  6. 72-5ptase expression promoted GLUT4 (zeige SLC2A4 Proteine) trafficking via a Rab11 (zeige RAB11A Proteine)-dependent pathway but not by Rab5 (zeige RAB5A Proteine)-mediated endocytosis. Therefore, endogenous PtdIns(3)P at the plasma membrane promotes GLUT4 (zeige SLC2A4 Proteine) translocation.

Human Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) Interaktionspartner

  1. OCRL (zeige OCRL Proteine)-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells

  2. The crystal structures of human INPP5B in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.

  3. study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl (zeige OCRL Proteine) function

  4. The homologous phosphatase Inpp5b was unable to complement the Ocrl1 (zeige OCRL Proteine)-dependent cell migration defect.

  5. INPP5B is also localised to the early secretory pathway including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC).

  6. The NH2-terminal region of OCRL, but not of INPP5B, binds clathrin heavy chain.

INPP5B Protein Überblick

Protein Überblick

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Genbezeichner und Symbole assoziert mit INPP5B

  • inositol polyphosphate-5-phosphatase B (INPP5B)
  • type II inositol 1,4,5-trisphosphate 5-phosphatase-like (LOC100224437)
  • inositol polyphosphate-5-phosphatase B L homeolog (inpp5b.L)
  • inositol polyphosphate 5-phosphatase OCRL-1 (LOC100159919)
  • inositol polyphosphate-5-phosphatase B (Inpp5b)
  • 5PTase Protein
  • 75kDa Protein
  • AW260155 Protein
  • INPP5P Protein

Bezeichner auf Proteinebene für INPP5B

inositol polyphosphate-5-phosphatase, 75kDa , inositol polyphosphate-5-phosphatase, 75kDa-like , type II inositol-1,4,5-trisphosphate 5-phosphatase-like , 5PTase , inositol polyphosphate-5-phosphatase, 75 kDa , phosphoinositide 5-phosphatase , type II inositol 1,4,5-trisphosphate 5-phosphatase , type II inositol-1,4,5-trisphosphate 5-phosphatase , 75 kDa inositol polyphosphate-5-phosphatase

GENE ID SPEZIES
419609 Gallus gallus
456767 Pan troglodytes
538291 Bos taurus
716851 Macaca mulatta
100054559 Equus caballus
100224437 Taeniopygia guttata
100350043 Oryctolagus cuniculus
100381066 Xenopus laevis
100159919 Acyrthosiphon pisum
100512110 Sus scrofa
16330 Mus musculus
362590 Rattus norvegicus
3633 Homo sapiens
100686373 Canis lupus familiaris
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