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INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. Zusätzlich bieten wir Ihnen INPP4B Antikörper (31) und INPP4B Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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Data provides evidence that INPP4B may play a role in regulating callosal axon formation by the formation of Satb2 (zeige SATB2 Proteine)-positive pyramidal neurons and controlling axon polarization.
Study provides evidence that INPP4B loss can promote follicular-like thyroid cancer progression and metastasis in the context of PTEN haploinsufficiency through the isoform-specific regulation of AKT (zeige AKT1 Proteine) signaling at the endosomes.
Results provide evidence that INPP4B is a bona fide tumor suppressor whose function is particularly important in situations of PTEN deficiency. Biochemical data demonstrates that INPP4B directly dephosphorylates PtdIns(3,4,5)P3.
ERalpha (zeige ESR1 Proteine) plays a protective role in bladder cancer initiation and growth at least partly via modulating the INPP4B/Akt (zeige AKT1 Proteine) pathway.
mice carrying the longer-latency Inpp4b allele(474R/548P)) exhibited significantly longer cortical motor evoked potential latencies indicating that INPP4B regulates nerve conduction velocity
Hyperactivation of the PI3K/AKT (zeige AKT1 Proteine) pathway caused by the decrease in INPP4B in granulosa cells promotes an ovarian environment defective in folliculogenesis and conducive to teratoma (zeige DND1 Proteine) formation.
In vivo mice deficient in Inpp4b displayed increased osteoclast differentiation rate and potential resulting in decreased bone mass and osteoporosis
This study provides first insight for a physiological role of PI-4-phosphatase II in the proerythroblast by controlling Epo (zeige EPO Proteine) responsiveness through a negative regulation of the PI3K/Akt (zeige AKT1 Proteine) pathway
High INPP4B expression is associated with melanoma.
INPP4B role in regulating phosphatidylinositol-3-kinase signaling in the triple-negative breast cancer cells.
Fisher's exact SubID was used to reveal EVI1 as a transcriptional regulator of INPP4B in AML; a finding which was validated in vitro. Next, we used CoxPH SubID to conduct a pan-cancer analysis of INPP4B's prognostic significance
INPP4B acted as a tumour suppressor in human prostate cancer
INPP4B is down-regulated in colorectal adenocarcinomas.
Collectively, these results suggest that INPP4B may function as an oncogenic driver in colon cancer, with potential implications for targeting INPP4B as a novel approach to treat this disease.
Study shows that IRF2 (zeige IRF2 Proteine) knockdown inhibits growth, colony formation of OCI/AML-2 (zeige RUNX3 Proteine), OCI/AML-3 (zeige RUNX2 Proteine), and THP-1 cells. In addition, IRF2 (zeige IRF2 Proteine) knockdown induces apoptosis of acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B contributes to the effects of IRF2 (zeige IRF2 Proteine) on apoptosis and growth of AML (zeige RUNX1 Proteine) cells. Thus, IRF2 (zeige IRF2 Proteine) serves as an important regulator in AML (zeige RUNX1 Proteine) by targeting INPP4B.
Immunohistochemical assessment of nestin (zeige NES Proteine) and INPP4b provides an accurate, accessible and inexpensive tool to identify basal-like breast cancer subtype in the clinically problematic setting of weak oestrogen receptor positivity
This study sthe (zeige GLRA1 Proteine) identification of a novel small transcript variant of INPP4B (INPP4B-S) that has a role in promoting proliferation of colon and breast cancer cells. INPP4B-S differed from full length INPP4B (INPP4B-FL) by the insertion of a small exon between exons 15 and 16 and the deletion of exons 20-24.
presented data indicate that INPP4B is crucial for docetaxel-resistant PCa (zeige FLVCR1 Proteine) cell survival, potentially by regulating EMT (zeige ITK Proteine) through the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.
inositol polyphosphate 4-phosphatase type II beta isoform
, type II inositol 3,4-bisphosphate 4-phosphatase
, type II inositol-3,4-bisphosphate 4-phosphatase
, inositol polyphosphate 4-phosphatase type II
, inositol polyphosphate-4-phosphatase type II 105kD
, inositol polyphosphate-4-phosphatase, type II, 105kD
, inositol polyphosphate 4-phosphatase II; 4-phosphatase II