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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Zusätzlich bieten wir Ihnen ID4 Proteine (6) und ID4 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 79 products:
Human Polyclonal ID4 Primary Antibody für WB - ABIN516801
Oatley, Kaucher, Racicot, Oatley: Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. in Biology of reproduction 2011
Human Polyclonal ID4 Primary Antibody für IHC (p), IHC - ABIN314651
Vincent, Li, Lee, Liu, Etter, Diaz-Perez, Taylor, Gkountela, Lindgren, Clark: Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells. in PLoS ONE 2011
Dog (Canine) Polyclonal ID4 Primary Antibody für WB - ABIN2780374
Yu, Liu, Vandeusen, Becknell, Dai, Wu, Raval, Liu, Ding, Mao, Liu, Smith, Lee, Rassenti, Marcucci, Byrd, Caligiuri, Plass: Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. in Nature genetics 2005
Show all 2 Pubmed References
ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1, Sox9 and PTEN.
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (zeige ESR1 Antikörper) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (zeige ID1 Antikörper)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (zeige PRMT5 Antikörper) and were hypomethylated in PRMT5 (zeige PRMT5 Antikörper)-deficient cells, suggesting that PRMT5 (zeige PRMT5 Antikörper) plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (zeige MAPK14 Antikörper) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (zeige WNT2 Antikörper) signaling in the developing AVC endocardium
results highlight a key role for MALAT1 in control of VEGFA (zeige VEGFA Antikörper) isoforms expression in breast cancer cells expressing gain-of-function mutant p53 (zeige TP53 Antikörper) and ID4 proteins.
Study demonstrates that ID4, can promote p53 (zeige TP53 Antikörper)- dependent apoptosis and senescence in prostate cancer cells by specifically modifying the acetylation of p53 (zeige TP53 Antikörper), which increases its transcriptional activity and promotes the expression of pro-apoptotic and cell cycle regulatory genes.
The cellular uptake of inhibitor of DNA binding 4 protein (ID4) resulted in increased apoptosis, decreased proliferation and colony formation.
Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.
The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) patients, and overexpression of Id4 promoted HCC (zeige FAM126A Antikörper) cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
ID4 selectively regulates AR activity through direct interaction with FKBP52 (zeige FKBP4 Antikörper).
High ID4 expression is associated with basal breast cancer.
A cell-autonomous positive-signaling circuit is associated with the PDGFB (zeige PDGFB Antikörper)-NO-ID4-regulatory axis in glioblastoma cells.
ID4 expression induces AR expression in PC3 (zeige PCSK1 Antikörper) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.
CEACAM1 (zeige CEACAM1 Antikörper) is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 (zeige HDAC4 Antikörper) and CaMK2D (zeige CAMK2D Antikörper), and the same kinase enables lumen formation by CEACAM1 (zeige CEACAM1 Antikörper)
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27