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The protein encoded by IBTK binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. Zusätzlich bieten wir Ihnen Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase Antikörper (31) und und viele weitere Produktgruppen zu diesem Protein an.
Data suggest that IBTKalpha is (a) localized in hepatocytes in endoplasmic reticulum (ER), (b) associates with specific proteins (LC3b (zeige MAP1LC3B ELISA Kits), SEC16A, SEC31A (zeige SEC31A ELISA Kits)), and (c) plays role in autophagy. Progression of nonalcoholic fatty liver disease is associated with changes in liver: (a) up-regulation of expression of IBTKalpha, (b) unfolded protein response, (c) ER stress, and (d) inhibition of autophagy.
CRL3 (zeige IL31RA ELISA Kits)(IBTK) is a novel ubiquitin ligase with regulatory roles in cellular pathways, such as the Pdcd4 (zeige PDCD4 ELISA Kits)-dependent translation of mRNAs
Depletion of IBTKalpha by short hairpin RNA reduced viability of cultured cells coincident with increased caspase 3 (zeige CASP3 ELISA Kits)/7 cleavage, suggesting that IBTKalpha is a key regulator in determining cell fate during the UPR.
A novel pathway of Btk (zeige BTK ELISA Kits) regulation via protein kinase C (zeige PKC ELISA Kits) phosphorylation of IBtkgamma.
three novel (Ala347fsX55, I355T, and Thr324fsX24) mutations in Bruton's tyrosine kinase (zeige BTK ELISA Kits) in patients with X-linked agammaglobulinemia
The IBTK gene encodes the proteins IBtk-alpha, beta and gamma that regulate the B cell receptor signalling through Bruton's tyrosine kinase (zeige BTK ELISA Kits), which promotes B cell survival and differentiation.
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
inhibitor of Bruton agammaglobulinemia tyrosine kinase
, inhibitor of Bruton's tyrosine kinase
, inhibitor of Bruton tyrosine kinase-like
, BTK-binding protein
, Bruton agammaglobulinemia tyrosine kinase inhibitor
, inhibitor of Bruton tyrosine kinase
, inhibitor of Bruton's tyrosine kinase-alpha
, inhibitor of Bruton's tyrosine kinase-beta
, inhibitor of Bruton's tyrosine kinase-gamma