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Translational regulator that ensures constant high levels of translation under amino acid starvation. Zusätzlich bieten wir Ihnen IMPACT Antikörper (33) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest that high expression of protein IMPACT homolog in non-immune cells acts as a protective mechanism against indoleamine 2,3-dioxygenase (IDO (zeige IDO1 Proteine))-induced GCN2 (zeige EIF2AK4 Proteine) activation, making them resistant to the amino acid-deprived environment caused by IDO (zeige IDO1 Proteine).
This study extends our understanding of the roles played by GCN1 in GCN2 (zeige EIF2AK4 Proteine) activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha (zeige EIF2A Proteine) kinase.
the participation of the GCN2-IMPACT module of translational regulation in a highly controlled step in the development of the nervous system.
IMPACT ensures constant high levels of translation and low levels of CREB-2 (zeige ATF4 Proteine) and GADD53 in specific neuronal cells under amino acid starvation conditions.
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).
imprinted and ancient
, imprinted and ancient gene protein homolog
, protein IMPACT
, Impact homolog (mouse)
, protein IMPACT-A
, imprinted and ancient gene protein homolog A
, Impact homolog
, RWD domain containing 5
, imprinted and ancient gene protein