Immune Receptor Expressed On Myeloid Cells 1 Proteine (IREM1)

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. Zusätzlich bieten wir Ihnen Immune Receptor Expressed On Myeloid Cells 1 Antikörper (81) und Immune Receptor Expressed On Myeloid Cells 1 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IREM1 246746 Q6SJQ7
IREM1 287818 Q566E6
IREM1 146722 Q8TDQ1
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
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Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
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Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$624.00
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Human Cells Human Fc Tag SDS-PAGE 50 μg Anmelden zum Anzeigen 14 bis 16 Tage
$285.35
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
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Hefe Human His tag 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$484.00
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,370.50
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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IREM1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
, ,
Rat (Rattus)

Human , , ,
, ,

Weitere Proteine zu Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Interaktionspartnern

Mouse (Murine) Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Interaktionspartner

  1. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils.

  2. Docking of the cocomplex structures onto a cryo-EM-derived model of MNoV suggests that each virion can make multiple CD300lf engagements, and thus, infection may be driven by the avidity of cell surface clustered CD300lf.

  3. sCD300lf bound on the mouse norovirus P domain. The receptor-binding site was located on the topside of the P2 subdomain and involved hydrophilic and hydrophobic interactions. The sCD300lf bound in a small cavity and was further supported by a positive surface charge on the sCD300lf and negative surface charge on the P domain.

  4. Our results indicate that direct interaction of MNV with two cell-surface molecules, CD300lf and CD300ld, dictates permissive noroviral infection.

  5. CD300f helps to maintain immune homeostasis by promoting macrophage clearance of self-antigens, while conversely inhibiting DC uptake and presentation of self-antigens.

  6. dextran sodium sulfate-treated Cd300f-/- mice exhibit attenuated disease activity and histopathology in comparison with wild type controls

  7. data highlight a previously unappreciated role for dendritic cells in controlling gut homeostasis and show that CD300f-dependent regulation of apoptotic cell uptake is essential for suppressing overactive dendritic cell-mediated inflammatory responses, thereby controlling the development of chronic gut inflammation.

  8. ceramide-CD300f binding inhibits LPS-induced skin inflammation, implicating CD300f as a negative regulator of Toll-like receptor 4 (TLR4) signaling in vivo

  9. CD300lf is essential for murine noroviruse binding and replication in cell lines and primary cells.

  10. CD300f is implicated in Wallerian degeneration and nerve regeneration by modulating both the influx and phenotype of macrophages

  11. Y276 phosphorylation is necessary for enhanced CD300f-mediated phagocytosis through the recruitment of the p85alpha regulatory subunit of phosphatidylinositol-3-kinase

  12. data highlight a previously unidentified role for CD300f in IL-4Ralpha-induced immune cell responses

  13. CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis.

  14. Several extracellular lipids (including ceramide) and lipoproteins were possible ligands for LMIR3.

  15. We conclude that expression of CD300f conveys additional capacity to recognize phosphatidylserine to myeloid cells.

  16. CLM-1 as a negative regulator of myeloid effector cells in autoimmune demyelination.

  17. DIgR2 is a functionally inhibitory receptor and can mediate negative signaling to regulate DC-initiated antigen-specific T-cell responses.

  18. the innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4

  19. These results indicate that CD300LF mediates caspase and endoplasmic reticulum stress-independent cell death by a novel mechanism.

  20. LMIR3 has a unique property to associate with FcRgamma and thereby functions as an activating receptor in concert with TLR4 stimulation

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Interaktionspartner

  1. this study demonstrates the role of CD300f in governing innate immune eosinophil activities in pediatric Crohn's disease patients and in active ulcerative colitis patients

  2. findings suggest that two rare heterozygous truncating variations (RPS24 Q191X and CD300LF P261fsX266) are risk candidates for autism spectrum disorder.

  3. CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.

  4. The data suggest that the neuroprotective role of CD300f would be the result of a complex network of cell interactions.

  5. peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling

  6. CD300f blocked the activation of cells induced by all TLR ligands

  7. Data indicate that CD300F is an active regulator of TLR-mediated macrophage activation through association with SHP-1 involving MyD88 and/or TRIF.

  8. Findings indicate that IREM-1 exerted its inhibitory effect on BAFF-medicated signalling through ITIM-mediated regulation of ERK activities in THP-1 cells.

  9. IgSF13 was identified from dendritic cells; preferentially expressed in myelo-monocytic cells, including monocytes, monocyte-derived DC and monocyte-related cell lines; may be involved in the negative regulation of specific leukocyte population [IgSF13]

  10. a novel inhibitory receptor of the Ig superfamily in myeloid cells. (IREM-1 = immune receptor expressed on myeloid cells-1)

  11. reveal a putative functional duality of the IREM-1 myeloid cell receptor

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Protein Überblick

Protein Überblick

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6\; MIM 176883) or SHIP (INPP5D\; MIM 601582) (Sui et al., 2004

Genbezeichner und Symbole assoziert mit IREM1

  • CD300 molecule like family member F (Cd300lf)
  • Cd300 molecule-like family member F (Cd300lf)
  • CD300 molecule like family member f (CD300LF)
  • CD300f Protein
  • CLIM1 Protein
  • CLM-1 Protein
  • CLM1 Protein
  • Digr2 Protein
  • F730004D16Rik Protein
  • IgSF13 Protein
  • IREM-1 Protein
  • IREM1 Protein
  • LMIR3 Protein
  • NKIR Protein
  • Pigr3 Protein
  • RGD1309733 Protein

Bezeichner auf Proteinebene für IREM1

CD300 antigen-like family member F , CMRF-35-like molecule 1 , CMRF35-like molecule 1 , DC-derived Ig-like receptor 2 , MAIR-5 , MAIR-V , leukocyte mono-Ig-like receptor 3 , myeloid-associated immunoglobulin-like receptor 5 , CD300 antigen like family member F , CLM-1 , CD300 molecule like family member f , NK inhibitory receptor , immune receptor expressed on myeloid cells 1 , immunoglobin superfamily member 13 , immunoglobulin superfamily member 13 , inhibitory receptor IREM1

GENE ID SPEZIES
246746 Mus musculus
287818 Rattus norvegicus
146722 Homo sapiens
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