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Increases intracellular lipid accumulation.
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Thus, macrophage Hilpda is crucial to foam-cell formation and lipid deposition, and to controlled prostaglandin-E2 production. By these means Hilpda promotes lesion formation and progression of atherosclerosis
HILPDA is highly abundant in adipose tissue, where its levels are induced by peroxisome proliferator-activated receptor gamma (zeige PPARG ELISA Kits) and beta-adrenergic stimulation. In contrast to the reported inhibition of lipolysis by HILPDA in hepatocytes, those data do not support an important direct role of HILPDA in the regulation of lipolysis in adipocytes in vivo and in vitro.
When fasted, HILPDA KO mice are unable to maintain body temperature and become hypothermic at 22 degrees C.
data uncover HILPDA as a novel PPAR (zeige PPARA ELISA Kits) target that raises hepatic triglyceride storage via regulation of triglyceride secretion.
HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas
Authors conclude that HIG2 is overexpressed in GBM and upregulated by hypoxia.
Study showed for the first time that HIG-2 and SOX11 mutually co-regulate each other, and that HIG-2 and SOX11 knock-down promote increased proliferation in a non-synergistic manner in primary mantle cell lymphoma cells.
Data indicate that HIG2 (hypoxia-inducible gene 2) is a HIF-1alpha (zeige HIF1A ELISA Kits) target in regulating cell survival during hypoxia.
there was no significant relationship between HIG2 expression and age, clinical stage and histology in either cervical cancer or endometrial cancer.
Data show that DBN1, SETMAR and HIG2 are direct transcriptional targets of the SOX11 protein.
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation (By similarity).
hypoxia-inducible gene 2 protein
, hypoxia-inducible lipid droplet-associated protein
, hypoxia inducible gene 2
, hypoxia-inducible protein 2