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The protein encoded by HABP2 is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. Zusätzlich bieten wir Ihnen HABP2 Antikörper (54) und HABP2 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
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The presence of the noninheritable V600E BRAF (zeige BRAF Proteine) mutation in this family supports Knudson's "double-hit" hypothesis for cancer development and suggests the involvement of more than 1 gene in the clinical expression of familial nonmedullary thyroid carcinoma.
The MI-SNP and MII-SNP FSAP gene polymorphisms were not predictive or prognostic biomarkers for coronary artery diseaseor its main risk factors.
NETs bind to FSAP, but do not activate pro-FSAP unless histones are released from NETs by DNAse (zeige DNASE2 Proteine). This activation of FSAP is likely to be important in diminishing the cytotoxic effect of histones, thus limiting the damaging effect of NETosis.
Regulation of gene expression by FSAP in vascular smooth muscle/endothelial cells accounts for its vasculo-regulatory properties.
The extent of CAC (zeige CA2 Proteine) in women is positively associated with total FSAP, but negatively associated with the specific activity of FSAP suggesting that FSAP may play a role in the evolution of CVD in women.
Report peptide substrates used in determining substrate specificity of Factor VII activating protease.
Two of 20 probands from families with history of PTC (zeige F9 Proteine) and breast carcinoma (BC) were evaluated by whole exome sequencing (WES) revealing HABP2 p.G534E.
No significant association was found between rs11196288 and early-onset ischemic stroke, large artery atherosclerotic stroke, or small vessel disease stroke. rs11196288 presented significant effect on late-onset SVD (zeige KCNJ13 Proteine) stroke susceptibility in the older population.
study on a wide series of familial non-medullary thyroid cancers indicates that the HABP2(G534E) variant is frequent, but does not segregate with the disease
Letter: G534E variant in HABP2 is not associated with non-medullary thyroid cancer in the Spanish population.
FSAP deficiency causes an increase in CCL2 (zeige CCL2 Proteine) expression and CCL2 (zeige CCL2 Proteine)-mediated infiltration of leukocytes into the injured vessel
the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta (zeige TGFB1 Proteine), was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD (zeige SMAD1 Proteine) binding sites.
Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice.
Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT (zeige AKT1 Proteine) pathway
Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury.
Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2 (zeige BMP2 Proteine)).
Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA (zeige RHOA Proteine)/Rho kinase (zeige ROCK2 Proteine) signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability.
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.
hyaluronan binding protein 2
, hyaluronan-binding protein 2-like
, factor VII activating protein
, factor VII-activating protease
, factor seven-activating protease
, hepatocyte growth factor activator-like protein
, hyaluronan-binding protein 2
, hyaluronic acid binding protein 2
, plasma hyaluronan binding protein
, plasma hyaluronan-binding protein
, hyaduronic acid-binding protein 2