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The protein encoded by HABP2 is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. Zusätzlich bieten wir Ihnen HABP2 Antikörper (40) und HABP2 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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Study showed that lower FSAP antigen plasma levels were associated with a higher chance of arterial recanalization after tissue plasminogen activator (zeige PLAT Proteine) treatment, suggesting an involvement of FSAP in tissue plasminogen activator (zeige PLAT Proteine)-induced clot (zeige TXNDC17 Proteine) lysis. FSAP antigen determination might be useful in predicting tissue plasminogen activator (zeige PLAT Proteine) response in stroke patients.
HABP2 polymorphisms are not associated with thyroid cancer.
the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta (zeige TGFB1 Proteine), was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD (zeige SMAD1 Proteine) binding sites.
Results show that G534E germline variant in HABP2 does not account for the familial nature of nonmedullary thyroid cancer in Australian kindreds but and is common in the general population.
omology modeling suggested that the Glu (zeige DCTN1 Proteine)-221 side chain could sterically hinder insertion of the N terminus into the HABP2 protease domain, helping to explain the detrimental effects of Glu (zeige DCTN1 Proteine)-221 substitution on HABP2 activity.
The data do not support the pathogenicity of the HABP2 c.1601G > A variant but highlight the existence of a new one that should be more extensively searched for in familial papillary thyroid carcinoma patients and its pathogenicity more carefully evaluated.
No evidence supporting a role for the HABP2 G534E variant (SNP rs7080536) in papillary thyroid carcinoma.
HABP2 G534E appears to be a susceptibility gene in a subgroup of Familial Non-Medullary Thyroid Cancer (FNMTC), providing important diagnostic implications for this hereditary thyroid cancer.
HABP2, which encodes an extracellular serine protease involved in coagulation, fibrinolysis, and inflammatory pathways, may be a genetic susceptibility locus for early-onset stroke. [Meta-Analysis]
Patients with Gram-negative sepsis caused by B. pseudomallei have abundant FSAP activation, which significantly correlates with stage of disease.
FSAP deficiency causes an increase in CCL2 (zeige CCL2 Proteine) expression and CCL2 (zeige CCL2 Proteine)-mediated infiltration of leukocytes into the injured vessel
Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice.
Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT (zeige AKT1 Proteine) pathway
Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury.
Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2 (zeige BMP2 Proteine)).
Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA (zeige RHOA Proteine)/Rho kinase (zeige ROCK2 Proteine) signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability.
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.
hyaluronan binding protein 2
, hyaluronan-binding protein 2-like
, factor VII activating protein
, factor VII-activating protease
, factor seven-activating protease
, hepatocyte growth factor activator-like protein
, hyaluronan-binding protein 2
, hyaluronic acid binding protein 2
, plasma hyaluronan binding protein
, plasma hyaluronan-binding protein
, hyaduronic acid-binding protein 2