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May play a role in cornification.. Zusätzlich bieten wir Ihnen Hornerin Antikörper (41) und Hornerin Kits (12) und viele weitere Produktgruppen zu diesem Protein an.
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These results indicate that hornerin is highly expressed in pancreatic tumor endothelium and alters tumor vessel parameters through a VEGF (zeige VEGFA Proteine)-independent mechanism. Angiogenesis is essential for solid tumor progression.
HRNR gene function is a target of FLG (zeige FGFR1 Proteine) adaptive sweep, and the functional FLG (zeige FGFR1 Proteine) variants that involve susceptibility to atopic dermatitis, seem to hitchhike the selective sweep on HRNR.
HRNR deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1 (zeige CAPN1 Proteine).
Human hornerin is a protein whose expression is changed by UVB irradiation.
Analysis of the rs877776 single nucleotide polymorphism in HRNR revealed neither a significant difference in genotype distribution between patients and controls nor a significant association of the variant with any atopic dermatitis-related phenotype.
Our data opens new possibilities for hornerin and its proteolytic fragments in the control of mammary cell function and breast cancer.
The data demonstrate that HRNR is a component of cornified cell envelopes of human epidermis. Its reduced expression in AD may contribute to the epidermal barrier defect observed in the disease.
hornerin is expressed in regenerating and psoriatic skin
HRNR is expressed in healthy skin and contributes to its barrier function
These results indicate that hornerin is highly expressed in pancreatic tumor endothelium and alters tumor vessel parameters through a VEGF (zeige VEGFA Proteine)-independent mechanism. Murine-specific hornerin knockdown in PDAC xenografts results in tumor vessels with decreased radii and tortuosity. Hornerin knockdown tumors have significantly reduced leakiness, increased oxygenation, and greater apoptosis.
May play a role in cornification.
filaggrin family member 3
, intermediate filament-associated protein
, S100 calcium binding protein A17, pseudogene 1
, S100 calcium binding protein A18, pseudogene 1
, protein S100-A16