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HOXC4 belongs to the homeobox family of genes. Zusätzlich bieten wir Ihnen Homeobox C4 Antikörper (84) und Homeobox C4 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment.
Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 (zeige HOXC6 Proteine) in lymphocytic progenitor cells.
Esr1 (zeige ESR1 Proteine) bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation.
Selective inhibition of class switching to IgG and IgE by recruitment of this and Oct-1 (zeige POU2F1 Proteine) proteins and Ku70 (zeige XRCC6 Proteine)/Ku86 (zeige XRCC5 Proteine) to newly identified ATTT cis (zeige CISH Proteine)-elements.
The hs1,2mediated enhancement of V(H) and C(H) promoter-driven transcription as induced by HoxC4 and Oct-1/Oct-2 suggests an important role of these homeodomain proteins in the overall regulation of the IgH locus expression.
The HOXC4 expression was clearly detected in all inv (zeige INVS Proteine)(7) positive patients.
HoxC4 directly activates the Aicda (zeige AICDA Proteine) promoter
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (zeige HOXA1 Proteine), HoxA5 (zeige HOXA5 Proteine), HoxC4 &HoxC8 (zeige HOXC8 Proteine) markedly enhanced. Irrespective of presence or absence of T3, insulin (zeige INS Proteine) down regulates HoxA10 (zeige HOXA10 Proteine). T3 results in over expression of HoxA5 (zeige HOXA5 Proteine), HoxC4 and HoxC8 (zeige HOXC8 Proteine) genes, whereas insulin (zeige INS Proteine) up regulates expression of only HoxC8 (zeige HOXC8 Proteine)
NF-kappaB (zeige NFKB1 Proteine) mediates APRIL-induced HoxC4 transcription.
These findings suggest that in lupus B cells, upregulation of HoxC4 plays a major role in dysregulation of AID expression.
Quantitative RNA analysis for the genes flanking the breakpoint indicated no changes in expression levels except for some homeobox (zeige PRRX1 Proteine) C (Hoxc) genes whose expression was elevated in developing and mature skin of the ears but not of other body regions.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.
homeobox protein Hox-C4
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, homeobox c4a
, homeobox gene C-4
, homeobox protein Hox-C4a
, homeo box 3E
, homeo box C4
, homeobox protein CP19
, homeobox protein Hox-3E
, homeobox protein Hox-3.5