Homeobox B4 Proteine (HOXB4)

HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. Zusätzlich bieten wir Ihnen Homeobox B4 Antikörper (96) und Homeobox B4 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte HOXB4 HOXB4 497988  
HOXB4 3214 P17483
HOXB4 15412 P10284
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Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,585.00
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,625.33
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$442.75
Details

HOXB4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Homeobox B4 (HOXB4) Interaktionspartnern

Zebrafish Homeobox B4 (HOXB4) Interaktionspartner

  1. the similarity of hoxb3a/Hoxa3 (zeige HOXA3 Proteine) regulatory mechanisms reflect the shared descent of both genes from a single ancestral paralog, expression of both genes in the posterior hindbrain and spinal cord in embryo

Human Homeobox B4 (HOXB4) Interaktionspartner

  1. HOXB4 knockout led to downregulation of P-glycoprotein, multidrug resistance-associated protein 1 (zeige ABCC1 Proteine) and breast cancer resistance protein expression and PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling activity, suggesting that repression of HOXB4 might be a key point to reverse Multidrug resistance of K562/ADM (zeige ADM Proteine) cells.

  2. This study provides novel evidences of the mechanisms integrating Notch (zeige NOTCH1 Proteine) and TNF-alpha (zeige TNF Proteine) signaling in the transcriptional induction of GATA3 (zeige GATA3 Proteine) and HOXB4.

  3. Increased expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic Progenitors but does not effect the maturation of red blood cells.

  4. The analysis of HOX (zeige MSH2 Proteine) expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX (zeige MSH2 Proteine) activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival

  5. HOXA4 (zeige HOXA4 Proteine) increases short-term repopulation to higher levels than HOXB4, which may involve Notch (zeige NOTCH1 Proteine) signaling to induce self-renewal of primitive hematopoietic cells

  6. showed that OAC1 treatment led to OCT4 (zeige POU5F1 Proteine)-mediated upregulation of HOXB4

  7. decreased methylation at HOXB3 (zeige HOXB3 Proteine) and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML (zeige RUNX1 Proteine), while increased DNA methylation (zeige HELLS Proteine) at DCC (zeige DCC Proteine) distinctive to the high-risk AML (zeige RUNX1 Proteine) was associated with increased gene expression

  8. Epigenetic analysis revealed that increased promoter methylation of HOXB4 correlates with decreased expression of its transcript in oral cancer cell lines. HOXB4 may work as an epigenetic biomarker gene.

  9. Our study demonstrates for the first time the regulation of HOXB4 by miR (zeige MLXIP Proteine)-23a

  10. our results outline the effects of HOXB4 in combination with stromal cells in the development of NK cells from embryonic stem cells.

Mouse (Murine) Homeobox B4 (HOXB4) Interaktionspartner

  1. Our data reveal a route to establishing functional multipotent HSCs that exploits aspects of in vitro differentiation, transcription factor re-specification with HoxB4 to enhance self-renewal, and Notch (zeige NOTCH1 Proteine)-mediated lineage specification

  2. can amplify long-term repopulating hematopoietic stem cells in a controlled way. This characteristic depends on a proline-rich sequence near the N terminus, which is unique among HOX (zeige MSH2 Proteine) genes and highly conserved in higher mammals

  3. Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Proteine)) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects.

  4. these studies define the transcriptional pathways involved in HOXB4 HSC (zeige FUT1 Proteine) expansion in vivo and identify repression of Prdm16 (zeige PRDM16 Proteine) transcription as a mechanism by which expanding HSCs avoid leukemic transformation.

  5. Hoxb4 favours the maintenance and increase of the CD4 (zeige CD4 Proteine) central memory phenotype T cell population.

  6. The results show a novel role for DNA methylation (zeige HELLS Proteine) in the alternative promoter usage at the Runx1 (zeige RUNX1 Proteine) locus and identify HOXB4 as a direct activator of the Runx1 (zeige RUNX1 Proteine) P1 promoter.

  7. Loss of Scmh1 (zeige SCMH1 Proteine) caused derepression of Hoxb4 and Hoxa9 (zeige HOXA9 Proteine), direct targets of Polycomb (zeige CBX2 Proteine)-group complex 1-mediated transcriptional silencing in hematopoietic cells.

  8. HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation.

  9. HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing hematopoietic stem cells into repopulating cells

  10. Hoxb4 expression therefore would not appear to correlate with the cycling status of fetal liver hematopoietic stem cells(HSCs), although highly proliferative HSCs from young BM show strong Hoxb4 expression.

Homeobox B4 (HOXB4) Protein Überblick

Protein Überblick

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Genbezeichner und Symbole assoziert mit Homeobox B4 Proteine (HOXB4)

  • homeobox B4 (hoxb4)
  • homeobox B4 (HOXB4)
  • hox4 protein (hox4)
  • hoxb4a protein (hoxb4a)
  • homeo box B4 (Hoxb4)
  • homeobox B4a (hoxb4a)
  • homeobox B4 (Hoxb4)
  • homeobox B4 S homeolog (hoxb4.S)
  • Chox-Z Protein
  • Hox-2.6 Protein
  • HOX-B4 Protein
  • HOX2 Protein
  • HOX2F Protein
  • hoxb4 Protein
  • RGD1560113 Protein
  • XHox-b4 Protein
  • Z-17 Protein
  • ZF-13 Protein
  • zf13 Protein

Bezeichner auf Proteinebene für Homeobox B4 Proteine (HOXB4)

homeobox B4 , homeo box B4 , hox4 protein , hoxb4a protein , Hoxb4a variant 2 , etID309956.3 , homeobox gene B-4 , homeobox protein Hox-B4a , homeobox protein Zf-13 , homeo box 2F , homeobox protein Hox-2.6 , homeobox protein Hox-2F , homeobox protein Hox-B4 , homeobox protein Hox-Z , xhox-1A

GENE ID SPEZIES
548393 Xenopus (Silurana) tropicalis
749218 Pan troglodytes
445807 Ciona intestinalis
100049485 Oryzias latipes
497988 Rattus norvegicus
30340 Danio rerio
3214 Homo sapiens
15412 Mus musculus
608915 Canis lupus familiaris
768240 Bos taurus
396230 Gallus gallus
734796 Xenopus laevis
Ausgewählte Anbieter für Homeobox B4 Proteine (HOXB4)
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