Homeobox B4 Proteine (HOXB4)

HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. Zusätzlich bieten wir Ihnen Homeobox B4 Antikörper (94) und Homeobox B4 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HOXB4 3214 P17483
HOXB4 15412 P10284
Ratte HOXB4 HOXB4 497988  
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Showing 9 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$340.00
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,585.00
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,625.33
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,629.00
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Hefe Takifugu rubripes His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,759.17
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Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
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Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
Details

HOXB4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Homeobox B4 (HOXB4) Interaktionspartnern

Human Homeobox B4 (HOXB4) Interaktionspartner

  1. our data confirms that CaP growth and chemo-/radioresistance in vivo is associated with over-expression of EpCAM, which serves both a functional biomarker and promising therapeutic target.

  2. Data suggests that an impaired capacity of eutopic and ectopic endometrial tissue to upregulate levels of HOXB4 during the proliferative phase may play a role in the pathogenesis of endometriosis and that further downregulation of HOXB4 may enhance ectopic implant invasiveness.

  3. Authors observed that induced expression of HOXB4 in the UW473 cell line significantly reduced in vitro cell proliferation and migration capability of UW473 cells with no effect on the in vivo tumorigenicity.

  4. Study revealed that HOXB4 was highly expressed in ovarian cancer cells. HOXB4 silencing enhanced the cytotoxic effect of Taxol and DDP by downregulating ABC transporters via inhibition of the PI3K/Akt signaling pathway. These results for the first time elucidated the critical roles and molecular basis of HOXB4 underlying drug resistance in ovarian cancer cells.

  5. HOXB4 knockout led to downregulation of P-glycoprotein, multidrug resistance-associated protein 1 and breast cancer resistance protein expression and PI3K/Akt signaling activity, suggesting that repression of HOXB4 might be a key point to reverse Multidrug resistance of K562/ADM cells.

  6. This study provides novel evidences of the mechanisms integrating Notch and TNF-alpha signaling in the transcriptional induction of GATA3 and HOXB4.

  7. Increased expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic Progenitors but does not effect the maturation of red blood cells.

  8. The analysis of HOX expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival

  9. HOXA4 increases short-term repopulation to higher levels than HOXB4, which may involve Notch signaling to induce self-renewal of primitive hematopoietic cells

  10. showed that OAC1 treatment led to OCT4-mediated upregulation of HOXB4

  11. decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression

  12. a crucial regulator of NK lytic function

  13. Epigenetic analysis revealed that increased promoter methylation of HOXB4 correlates with decreased expression of its transcript in oral cancer cell lines. HOXB4 may work as an epigenetic biomarker gene.

  14. Our study demonstrates for the first time the regulation of HOXB4 by miR-23a

  15. our results outline the effects of HOXB4 in combination with stromal cells in the development of NK cells from embryonic stem cells.

  16. GATA-2 directly regulates HOXB4 expression in hematopoietic stem cells, which may play an important role in the development and/or progression of aplastic anemia.

  17. HOXB4-positivity as an independent predictor of overall survival of acute myeloid leukemia patients

  18. Expressions of ABCB1, BMI-1, HOXB4 were not detected in the patients with non-malignant hematologic diseases, but were higher in de novo acute leukemia patients and lower in patients in complete remission.

  19. Comparative transcriptome analysis of CD34(+) cells subjected or not to HOXB4 or HOXC4 demonstrated that both homeoproteins regulate the same set of genes, some of which encode key hematopoietic factors and signaling molecules.

  20. cytomegalovirus infection markedly down-regulated HOXB4 expression which affected proliferation and differentiation of erythroid and lymphocyte progenitor cells.

Mouse (Murine) Homeobox B4 (HOXB4) Interaktionspartner

  1. HOXB4 promoted the formation of hemogenic endothelium cells.

  2. Our data reveal a route to establishing functional multipotent HSCs that exploits aspects of in vitro differentiation, transcription factor re-specification with HoxB4 to enhance self-renewal, and Notch-mediated lineage specification

  3. can amplify long-term repopulating hematopoietic stem cells in a controlled way. This characteristic depends on a proline-rich sequence near the N terminus, which is unique among HOX genes and highly conserved in higher mammals

  4. Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects.

  5. these studies define the transcriptional pathways involved in HOXB4 HSC expansion in vivo and identify repression of Prdm16 transcription as a mechanism by which expanding HSCs avoid leukemic transformation.

  6. Hoxb4 favours the maintenance and increase of the CD4 central memory phenotype T cell population.

  7. The results show a novel role for DNA methylation in the alternative promoter usage at the Runx1 locus and identify HOXB4 as a direct activator of the Runx1 P1 promoter.

  8. Loss of Scmh1 caused derepression of Hoxb4 and Hoxa9, direct targets of Polycomb-group complex 1-mediated transcriptional silencing in hematopoietic cells.

  9. HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation.

  10. HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing hematopoietic stem cells into repopulating cells

  11. Hoxb4 expression therefore would not appear to correlate with the cycling status of fetal liver hematopoietic stem cells(HSCs), although highly proliferative HSCs from young BM show strong Hoxb4 expression.

  12. Data suggest that transduced Hoxb4 down-regulates Geminin protein probably by constituting the E3 ubiquitin ligase for Geminin to provide hematopoietic stem and progenitor cells with proliferation potential.

  13. Results compare the hematopoietic inductive effects of stromal cell lines derived from different subregions of the embryonic aorta-gonad-mesonephros tissue with the commonly used OP9 stromal cell line and with HOXB4 activation.

  14. Primitive hematopoietic stem cells (HSCs) are poised to become definitive adult HSCs and this transition can be promoted by HoxB4 expression.

  15. relative levels of NFY and YY1 binding could represent a mechanism for balancing activation and repression of Hoxb4 through the same site

  16. These data suggest a direct physiological role of Hoxb4 and Hoxb3 in regulating stem cell regeneration and that these genes are required for maximal proliferative response.

  17. NF-Y is a developmentally regulated inducer of the HOXB4 gene in hematopoietic cells.

  18. p38 mitogen-activated protein kinase (MAPK) was responsible for the TPO-induced Hoxb4 elevation

  19. the deficiency of Hoxb4 leads to hypocellularity in hematopoietic organs and impaired proliferative capacity but Hoxb4 is not required for the generation of HSCs or the maintenance of steady state hematopoiesis.

  20. Immunohistochemical analysis of transverse spinal cord sections demonstrated diffuse expression of Hoxb4 throughout the spinal cord at E12.5, after which expression was confined primarily to the presumptive gray matter.

Zebrafish Homeobox B4 (HOXB4) Interaktionspartner

  1. Hoxb4a favours the development of hematopoietic progenitor cells originated from hemangioblasts in vivo

  2. the similarity of hoxb3a/Hoxa3 regulatory mechanisms reflect the shared descent of both genes from a single ancestral paralog, expression of both genes in the posterior hindbrain and spinal cord in embryo

  3. hoxb4a in combination with its paralogs may play a significant role in the development of precerebellar, vagal, and pectoral fin neuronal subtypes

  4. continuous presence of hoxb4a positive neurons may provide a developmental plasticity for behavior-specific circuits to accommodate experience- and growth-related changes

Homeobox B4 (HOXB4) Protein Überblick

Protein Überblick

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Genbezeichner und Symbole assoziert mit Homeobox B4 Proteine (HOXB4)

  • homeobox B4 (HOXB4)
  • homeobox B4 (Hoxb4)
  • homeobox B4 (hoxb4)
  • homeobox B4 S homeolog (hoxb4.S)
  • homeobox B4a (hoxb4a)
  • hox4 protein (hox4)
  • homeo box B4 (Hoxb4)
  • hoxb4a protein (hoxb4a)
  • Chox-Z Protein
  • FrHOXB-4 Protein
  • hox-2.6 Protein
  • HOX-B4 Protein
  • hox2 Protein
  • hox2f Protein
  • HOXB4 Protein
  • HoxB4a Protein
  • RGD1560113 Protein
  • XHox-b4 Protein
  • Z-17 Protein
  • ZF-13 Protein
  • zf13 Protein

Bezeichner auf Proteinebene für Homeobox B4 Proteine (HOXB4)

homeo box 2F , homeo box B4 , homeobox protein Hox-2.6 , homeobox protein Hox-2F , homeobox protein Hox-B4 , homeobox protein Hox-Z , homeobox B4 , xhox-1A , Hoxb4a variant 2 , etID309956.3 , homeobox gene B-4 , homeobox protein Hox-B4a , homeobox protein Zf-13 , hox4 protein , hoxb4a protein , LOW QUALITY PROTEIN: homeobox protein Hox-B4 , FrHOXB-4 , Homeobox protein Hox-B4a , homeobox protein HoxB4a

GENE ID SPEZIES
3214 Homo sapiens
15412 Mus musculus
396230 Gallus gallus
548393 Xenopus (Silurana) tropicalis
608915 Canis lupus familiaris
734796 Xenopus laevis
749218 Pan troglodytes
768240 Bos taurus
30340 Danio rerio
445807 Ciona intestinalis
497988 Rattus norvegicus
100049485 Oryzias latipes
100719955 Cavia porcellus
101061711 Takifugu rubripes
101096120 Felis catus
Ausgewählte Anbieter für Homeobox B4 Proteine (HOXB4)
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