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HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain.
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the similarity of hoxb3a/Hoxa3 (zeige HOXA3 Proteine) regulatory mechanisms reflect the shared descent of both genes from a single ancestral paralog, expression of both genes in the posterior hindbrain and spinal cord in embryo
Study revealed that HOXB4 was highly expressed in ovarian cancer cells. HOXB4 silencing enhanced the cytotoxic effect of Taxol and DDP (zeige TIMM8A Proteine) by downregulating ABC (zeige ABCB6 Proteine) transporters via inhibition of the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway. These results for the first time elucidated the critical roles and molecular basis of HOXB4 underlying drug resistance in ovarian cancer cells.
HOXB4 knockout led to downregulation of P-glycoprotein, multidrug resistance-associated protein 1 (zeige ABCC1 Proteine) and breast cancer resistance protein expression and PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling activity, suggesting that repression of HOXB4 might be a key point to reverse Multidrug resistance of K562/ADM (zeige ADM Proteine) cells.
This study provides novel evidences of the mechanisms integrating Notch (zeige NOTCH1 Proteine) and TNF-alpha (zeige TNF Proteine) signaling in the transcriptional induction of GATA3 (zeige GATA3 Proteine) and HOXB4.
Increased expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic Progenitors but does not effect the maturation of red blood cells.
The analysis of HOX (zeige MSH2 Proteine) expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX (zeige MSH2 Proteine) activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival
HOXA4 (zeige HOXA4 Proteine) increases short-term repopulation to higher levels than HOXB4, which may involve Notch (zeige NOTCH1 Proteine) signaling to induce self-renewal of primitive hematopoietic cells
showed that OAC1 treatment led to OCT4 (zeige POU5F1 Proteine)-mediated upregulation of HOXB4
decreased methylation at HOXB3 (zeige HOXB3 Proteine) and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML (zeige RUNX1 Proteine), while increased DNA methylation (zeige HELLS Proteine) at DCC (zeige DCC Proteine) distinctive to the high-risk AML (zeige RUNX1 Proteine) was associated with increased gene expression
Epigenetic analysis revealed that increased promoter methylation of HOXB4 correlates with decreased expression of its transcript in oral cancer cell lines. HOXB4 may work as an epigenetic biomarker gene.
Our study demonstrates for the first time the regulation of HOXB4 by miR (zeige MLXIP Proteine)-23a
Our data reveal a route to establishing functional multipotent HSCs that exploits aspects of in vitro differentiation, transcription factor re-specification with HoxB4 to enhance self-renewal, and Notch (zeige NOTCH1 Proteine)-mediated lineage specification
can amplify long-term repopulating hematopoietic stem cells in a controlled way. This characteristic depends on a proline-rich sequence near the N terminus, which is unique among HOX (zeige MSH2 Proteine) genes and highly conserved in higher mammals
Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Proteine)) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects.
these studies define the transcriptional pathways involved in HOXB4 HSC (zeige FUT1 Proteine) expansion in vivo and identify repression of Prdm16 (zeige PRDM16 Proteine) transcription as a mechanism by which expanding HSCs avoid leukemic transformation.
Hoxb4 favours the maintenance and increase of the CD4 (zeige CD4 Proteine) central memory phenotype T cell population.
The results show a novel role for DNA methylation (zeige HELLS Proteine) in the alternative promoter usage at the Runx1 (zeige RUNX1 Proteine) locus and identify HOXB4 as a direct activator of the Runx1 (zeige RUNX1 Proteine) P1 promoter.
Loss of Scmh1 (zeige SCMH1 Proteine) caused derepression of Hoxb4 and Hoxa9 (zeige HOXA9 Proteine), direct targets of Polycomb (zeige CBX2 Proteine)-group complex 1-mediated transcriptional silencing in hematopoietic cells.
HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation.
HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing hematopoietic stem cells into repopulating cells
Hoxb4 expression therefore would not appear to correlate with the cycling status of fetal liver hematopoietic stem cells(HSCs), although highly proliferative HSCs from young BM show strong Hoxb4 expression.
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
, homeo box B4
, hox4 protein
, hoxb4a protein
, Hoxb4a variant 2
, homeobox gene B-4
, homeobox protein Hox-B4a
, homeobox protein Zf-13
, homeo box 2F
, homeobox protein Hox-2.6
, homeobox protein Hox-2F
, homeobox protein Hox-B4
, homeobox protein Hox-Z