Homeobox B4 Proteine (HOXB4)

HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. Zusätzlich bieten wir Ihnen Homeobox B4 Antikörper (93) und Homeobox B4 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HOXB4 3214 P17483
HOXB4 15412 P10284
Ratte HOXB4 HOXB4 497988  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top Homeobox B4 Proteine auf antikoerper-online.de

Showing 9 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Takifugu rubripes His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days

HOXB4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
Mouse (Murine)

Weitere Proteine zu Homeobox B4 (HOXB4) Interaktionspartnern

Human Homeobox B4 (HOXB4) Interaktionspartner

  1. Data suggests that an impaired capacity of eutopic and ectopic endometrial tissue to upregulate levels of HOXB4 during the proliferative phase may play a role in the pathogenesis of endometriosis and that further downregulation of HOXB4 may enhance ectopic implant invasiveness.

  2. Authors observed that induced expression of HOXB4 in the UW473 cell line significantly reduced in vitro cell proliferation and migration capability of UW473 cells with no effect on the in vivo tumorigenicity.

  3. Study revealed that HOXB4 was highly expressed in ovarian cancer cells. HOXB4 silencing enhanced the cytotoxic effect of Taxol and DDP (zeige TIMM8A Proteine) by downregulating ABC (zeige ABCB6 Proteine) transporters via inhibition of the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway. These results for the first time elucidated the critical roles and molecular basis of HOXB4 underlying drug resistance in ovarian cancer cells.

  4. HOXB4 knockout led to downregulation of P-glycoprotein, multidrug resistance-associated protein 1 (zeige ABCC1 Proteine) and breast cancer resistance protein expression and PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling activity, suggesting that repression of HOXB4 might be a key point to reverse Multidrug resistance of K562/ADM (zeige ADM Proteine) cells.

  5. This study provides novel evidences of the mechanisms integrating Notch (zeige NOTCH1 Proteine) and TNF-alpha (zeige TNF Proteine) signaling in the transcriptional induction of GATA3 (zeige GATA3 Proteine) and HOXB4.

  6. Increased expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic Progenitors but does not effect the maturation of red blood cells.

  7. The analysis of HOX expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival

  8. HOXA4 (zeige HOXA4 Proteine) increases short-term repopulation to higher levels than HOXB4, which may involve Notch (zeige NOTCH1 Proteine) signaling to induce self-renewal of primitive hematopoietic cells

  9. showed that OAC1 treatment led to OCT4 (zeige POU5F1 Proteine)-mediated upregulation of HOXB4

  10. decreased methylation at HOXB3 (zeige HOXB3 Proteine) and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML (zeige RUNX1 Proteine), while increased DNA methylation (zeige HELLS Proteine) at DCC (zeige DCC Proteine) distinctive to the high-risk AML (zeige RUNX1 Proteine) was associated with increased gene expression

Mouse (Murine) Homeobox B4 (HOXB4) Interaktionspartner

  1. Our data reveal a route to establishing functional multipotent HSCs that exploits aspects of in vitro differentiation, transcription factor re-specification with HoxB4 to enhance self-renewal, and Notch (zeige NOTCH1 Proteine)-mediated lineage specification

  2. can amplify long-term repopulating hematopoietic stem cells in a controlled way. This characteristic depends on a proline-rich sequence near the N terminus, which is unique among HOX genes and highly conserved in higher mammals

  3. Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Proteine)) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects.

  4. these studies define the transcriptional pathways involved in HOXB4 HSC (zeige FUT1 Proteine) expansion in vivo and identify repression of Prdm16 (zeige PRDM16 Proteine) transcription as a mechanism by which expanding HSCs avoid leukemic transformation.

  5. Hoxb4 favours the maintenance and increase of the CD4 (zeige CD4 Proteine) central memory phenotype T cell population.

  6. The results show a novel role for DNA methylation (zeige HELLS Proteine) in the alternative promoter usage at the Runx1 (zeige RUNX1 Proteine) locus and identify HOXB4 as a direct activator of the Runx1 (zeige RUNX1 Proteine) P1 promoter.

  7. Loss of Scmh1 (zeige SCMH1 Proteine) caused derepression of Hoxb4 and Hoxa9 (zeige HOXA9 Proteine), direct targets of Polycomb (zeige CBX2 Proteine)-group complex 1-mediated transcriptional silencing in hematopoietic cells.

  8. HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation.

  9. HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing hematopoietic stem cells into repopulating cells

  10. Hoxb4 expression therefore would not appear to correlate with the cycling status of fetal liver hematopoietic stem cells(HSCs), although highly proliferative HSCs from young BM show strong Hoxb4 expression.

Zebrafish Homeobox B4 (HOXB4) Interaktionspartner

  1. the similarity of hoxb3a/Hoxa3 (zeige HOXA3 Proteine) regulatory mechanisms reflect the shared descent of both genes from a single ancestral paralog, expression of both genes in the posterior hindbrain and spinal cord in embryo

Homeobox B4 (HOXB4) Protein Überblick

Protein Überblick

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Genbezeichner und Symbole assoziert mit Homeobox B4 Proteine (HOXB4)

  • homeobox B4 (HOXB4)
  • homeobox B4 (Hoxb4)
  • homeobox B4 (hoxb4)
  • homeobox B4 S homeolog (hoxb4.S)
  • homeobox B4a (hoxb4a)
  • hox4 protein (hox4)
  • homeo box B4 (Hoxb4)
  • hoxb4a protein (hoxb4a)
  • Chox-Z Protein
  • FrHOXB-4 Protein
  • hox-2.6 Protein
  • HOX-B4 Protein
  • hox2 Protein
  • hox2f Protein
  • HOXB4 Protein
  • HoxB4a Protein
  • RGD1560113 Protein
  • XHox-b4 Protein
  • Z-17 Protein
  • ZF-13 Protein
  • zf13 Protein

Bezeichner auf Proteinebene für Homeobox B4 Proteine (HOXB4)

homeo box 2F , homeo box B4 , homeobox protein Hox-2.6 , homeobox protein Hox-2F , homeobox protein Hox-B4 , homeobox protein Hox-Z , homeobox B4 , xhox-1A , Hoxb4a variant 2 , etID309956.3 , homeobox gene B-4 , homeobox protein Hox-B4a , homeobox protein Zf-13 , hox4 protein , hoxb4a protein , LOW QUALITY PROTEIN: homeobox protein Hox-B4 , FrHOXB-4 , Homeobox protein Hox-B4a , homeobox protein HoxB4a

3214 Homo sapiens
15412 Mus musculus
396230 Gallus gallus
548393 Xenopus (Silurana) tropicalis
608915 Canis lupus familiaris
734796 Xenopus laevis
749218 Pan troglodytes
768240 Bos taurus
30340 Danio rerio
445807 Ciona intestinalis
497988 Rattus norvegicus
100049485 Oryzias latipes
100719955 Cavia porcellus
101061711 Takifugu rubripes
101096120 Felis catus
Ausgewählte Anbieter für Homeobox B4 Proteine (HOXB4)
Haben Sie etwas anderes gesucht?