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HDAC11 encodes a class IV histone deacetylase. Zusätzlich bieten wir Ihnen Histone Deacetylase 11 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal HDAC11 Primary Antibody für IHC (p), ELISA - ABIN543304
Bradbury, Khanim, Hayden, Bunce, White, Drayson, Craddock, Turner: Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. in Leukemia 2005
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Human Polyclonal HDAC11 Primary Antibody für IHC (p), ELISA - ABIN543305
Voelter-Mahlknecht, Ho, Mahlknecht: Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene. in International journal of molecular medicine 2005
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Human Polyclonal HDAC11 Primary Antibody für IHC (p), WB - ABIN387965
Gao, Cueto, Asselbergs, Atadja: Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. in The Journal of biological chemistry 2002
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Human Polyclonal HDAC11 Primary Antibody für IHC (p), WB - ABIN387964
Janssen, Schmalbach, Boeselt, Sarlette, Dengler, Petri: Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis. in Journal of neuropathology and experimental neurology 2010
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Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts.
Mycobacterium tuberculosis infection disturbs the HDAC6/HDAC11 levels to induce IL-10 expression in macrophages.
HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10. Hence, antagonizing HDAC11 activity may have anti-tumor potential, whereas activating HDAC11 may be useful to treat chronic inflammation or autoimmunity.
Results showed that the high levels of HDAC11 and lower levels of p53 were detected in pituitary tumor cells. A negative correlation was detected between the data of HDAC11 and p53.
Our study identified a group of cell cycle-promoting genes regulated by HDAC11.
High HDAC11 expression is associated with neoplasms.
Data indicate a pronounced deregulation of HDAC genes HDAC9 and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF).
These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression.
HDAC11 associates with replication origins inhibits Cdt1-induced re-replication and suppresses MCM loading.
We found a reduction of HDAC 11 mRNA and increased HDAC 2 levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls.
cloning and functional characterization
Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer.
the absence of tumour-specific somatic events in WNT7A and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours
HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells.
Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11
HDAC11-suppression suppresses oxidative stress to reduce apoptosis and inflammation in Fructose-treated primary cardiomyocytes.
Results demonstrate that HDAC11 is an important metabolic regulator. Mice that lack HDAC11 are protected from diet-induced obesity and fatty liver.
our results indicate that HDAC11 would suppress myoblast differentiation via regulation of MyoD-dependent transcription. These findings suggest that HDAC11 is a novel critical target for controlling myoblast differentiation.
we have been able to demonstrate a lineage-restricted overexpression of HDAC11 in neutrophils and committed neutrophil precursors and it appears to associate with the transcription machinery, possibly regulating the expression of inflammatory and migratory genes in neutrophils. Our results highlight a unique and novel role for HDAC11
our results indicate that the alcohol-induced responsiveness of Kupffer cells to gut-derived endotoxin, in part, is governed by miR-155 and HDAC11
HDAC11-knockout T cells displayed enhanced proliferation, proinflammatory cytokine production, and effector molecule expression of Eomes and TBX21 transcription factors previously shown to regulate inflammatory cytokine and effector molecule production.
HDAC11 appears to function as a negative regulator of myeloid-derived suppressor cells expansion/function in vivo.
HDAC6, primarily a cytoplasmic protein, associates with HDAC11 and modulates the expression of IL-10 as a transcriptional activator.
The HDAC11 transcript is a PDGF target; the HDAC11 mRNA abundance correlates inversely with proliferative status.
Male gender and male hormones accelerate kidney ischemia reperfusion-induced decreases in expression and binding of HDAC11, resulting in an increase in PAI-1 expression.
Role for HDAC11 in central nervous system histone deacetylation and the development of oligodendrocytes and neurons during postnatal development.
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
, histone deacetylase X
, histone deacetylase 11