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HDAC11 encodes a class IV histone deacetylase. Zusätzlich bieten wir Ihnen Histone Deacetylase 11 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal HDAC11 Primary Antibody für IHC (p), WB - ABIN387965
Bradbury, Khanim, Hayden, Bunce, White, Drayson, Craddock, Turner: Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. in Leukemia 2005
Show all 4 Pubmed References
Human Polyclonal HDAC11 Primary Antibody für IHC (p), WB - ABIN387964
Gao, Cueto, Asselbergs, Atadja: Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. in The Journal of biological chemistry 2002
Show all 3 Pubmed References
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10 (zeige IL10 Antikörper). Hence, antagonizing HDAC11 activity may have anti-tumor potential, whereas activating HDAC11 may be useful to treat chronic inflammation or autoimmunity.
Results showed that the high levels of HDAC11 and lower levels of p53 (zeige TP53 Antikörper) were detected in pituitary tumor cells. A negative correlation was detected between the data of HDAC11 and p53 (zeige TP53 Antikörper).
Our study identified a group of cell cycle-promoting genes regulated by HDAC11.
High HDAC11 expression is associated with neoplasms.
Data indicate a pronounced deregulation of HDAC (zeige HDAC3 Antikörper) genes HDAC9 (zeige HDAC9 Antikörper) and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (zeige IGF2BP3 Antikörper) (PV) and primary myelofibrosis (PMF (zeige PRB1 Antikörper)).
These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L (zeige TNFSF4 Antikörper) expression.
HDAC11 associates with replication origins inhibits Cdt1 (zeige CDT1 Antikörper)-induced re-replication and suppresses MCM loading.
We found a reduction of HDAC 11 mRNA and increased HDAC 2 (zeige HDAC2 Antikörper) levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls.
Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer.
the absence of tumour-specific somatic events in WNT7A (zeige WNT7A Antikörper) and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours
our results indicate that HDAC11 would suppress myoblast differentiation via regulation of MyoD (zeige MYOD1 Antikörper)-dependent transcription. These findings suggest that HDAC11 is a novel critical target for controlling myoblast differentiation.
we have been able to demonstrate a lineage-restricted overexpression of HDAC11 in neutrophils and committed neutrophil precursors and it appears to associate with the transcription machinery, possibly regulating the expression of inflammatory and migratory genes in neutrophils. Our results highlight a unique and novel role for HDAC11
our results indicate that the alcohol-induced responsiveness of Kupffer cells to gut (zeige GUSB Antikörper)-derived endotoxin, in part, is governed by miR (zeige MLXIP Antikörper)-155 and HDAC11
HDAC11-knockout T cells displayed enhanced proliferation, proinflammatory cytokine production, and effector molecule expression of Eomes and TBX21 transcription factors previously shown to regulate inflammatory cytokine and effector molecule production.
HDAC11 appears to function as a negative regulator of myeloid-derived suppressor cells expansion/function in vivo.
HDAC6 (zeige HDAC6 Antikörper), primarily a cytoplasmic protein (zeige BLZF1 Antikörper), associates with HDAC11 and modulates the expression of IL-10 (zeige IL10 Antikörper) as a transcriptional activator.
The HDAC11 transcript is a PDGF (zeige PDGFA Antikörper) target; the HDAC11 mRNA abundance correlates inversely with proliferative status.
Male gender and male hormones accelerate kidney ischemia reperfusion-induced decreases in expression and binding of HDAC11, resulting in an increase in PAI-1 (zeige SERPINE1 Antikörper) expression.
Role for HDAC11 in central nervous system histone deacetylation and the development of oligodendrocytes and neurons during postnatal development.
HDAC11 negatively regulated expression of the gene encoding interleukin 10 (zeige IL10 Antikörper) in antigen-presenting cells.
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
, histone deacetylase X
, histone deacetylase 11