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The protein encoded by HDLBP binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells.
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vigilin has been shown to bind over 700 mRNAs and has been associated with cancer progression and cardiovascular disease.
this study shows that vigilin (HDLBP) binds and negatively regulates MICB (zeige MICB Proteine) expression through its 5'UTR, and that vigilin downregulation in target cells leads to NK cell activation against said target cells
progressively upregulated vigilin may serve as a molecular risk marker for hepatocellular carcinoma development, and targeting vigilin may help to inhibit hepatocellular carcinoma cell growth, survival and migration.
CTCF (zeige CTCF Proteine) may regulate vigilin behavior and thus indirectly influence the binding of HP1alpha (zeige CBX5 Proteine) to the satellite 2 locus
Vigilin may have a relationship with hepatocellular carcinoma progression and proliferation.
identified a competition for binding the 69-nt sequence, through which vigilin and HuR (zeige ELAVL1 Proteine) exert opposing effects on c-fms (zeige CSF1R Proteine) expression, suggesting a role for vigilin in suppression of breast cancer progression
Expression profiles of human VIGILIN, H19, and IGF2 mRNA increased with cell-cycle prograssion.
RNA interference studies indicate vigilin is essential for cell viability but is not a global regulator of translation.
evidence that vigilin is bound to the ribosomal complex.
C-terminal domain of human vigilin binds to the histone methyltransferase SUV39H1 (zeige SUV39H1 Proteine) in vivo;a new model for vigilin-mediated, RNA-induced gene silencing is presented.
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. Three transcript variants encoding two different isoforms have been found for this gene.
, high density lipoprotein-binding protein
, high density lipoprotein binding protein (vigilin)
, high density lipoprotein binding protein
, HDL binding protein
, lipoprotein-binding protein
, high density lipoprotein (HDL) binding protein
, high density lipoprotein-binding protein (vigilin)