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Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Zusätzlich bieten wir Ihnen HNRNPL Antikörper (118) und HNRNPL Kits (16) und viele weitere Produktgruppen zu diesem Protein an.
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High expression of HnRNP L is associated with oral squamous cell carcinoma.
uc.345 could upregulate the hnRNPL expression and that inhibition of (hnRNPL) dampens the tumorigenesis capability of uc.345.
HnRNP L is a novel regulator of HPV16 RNA processing.HnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt (zeige AKT1 Proteine) kinase-dependent manner.
Translation of VEGFA (zeige VEGFA Proteine) mRNA in myeloid cells is dictated by a bi-directional interaction between miR (zeige MLXIP Proteine)-574-3p, a CA-rich microRNA, and hnRNP L. In normoxia, miR (zeige MLXIP Proteine)-574-3p, acting as a decoy, binds cytoplasmic hnRNP L and prevents its binding to the CARE and stimulation of VEGFA (zeige VEGFA Proteine) mRNA translation, simultaneously permitting miR (zeige MLXIP Proteine)-297-mediated translational silencing.
High HNRNPL expression is associated with prostate cancer.
hnRNP-L contributes to poor prognosis and tumor progression of BC by inhibiting the intrinsic apoptotic signaling and enhancing MAPK (zeige MAPK1 Proteine) signaling pathways
hnRNP L inhibits proximal 5'SS but promotes two consecutive distal 5'SS splicing, antagonizing SRSF1 (zeige SRSF1 Proteine) roles in KLF6 (zeige KLF6 Proteine) pre-mRNA splicing.
HNRNPL acts as the adaptor to combine the two substructures and form the intact Sam68 (zeige KHDRBS1 Proteine) nuclear body through the interaction of two sets of RNA recognition motifs with the putative architectural RNA in the respective substructures.
hnRNPA2B1 (zeige HNRNPA2B1 Proteine), hnRNPD (zeige HNRNPD Proteine), hnRNPL , and YBX1 (zeige YBX1 Proteine) might play important roles in gastric cancer tumorigenesis.
hnRNP L controls inclusion of a broad spectrum of alternative cassette exons in T cells.
data suggest that hnRNP L is critical for the survival and functional integrity of HSCs by restricting the activation of caspase (zeige CASP3 Proteine)-dependent death receptor pathways
lncLGR facilitates the recruitment of hnRNPL to the GCK (zeige GCK Proteine) promoter and suppresses GCK (zeige GCK Proteine) transcription.
Hnrnpl binds to p53 (zeige TP53 Proteine) and inhibits its activation in mouse embryonic stem cells.
Aire (zeige AIRE Proteine)-containing complexes include 7SK RNA, the latter interaction disrupted by HNRNPL knockdown, suggesting that HNRNPL may partake in delivering inactive P-TEFb (zeige CCNT1 Proteine) to Aire (zeige AIRE Proteine)
Results identify a cancer-specific mechanism of hnRNP L phosphorylation and subsequent lowering of the caspase (zeige CASP3 Proteine)-9a/9b ratio, which is required for the tumorigenic capacity of non-small cell lung cancer cells.
identified hnRNP L as a novel Sam68 (zeige KHDRBS1 Proteine)-interacting protein partner.
Inflammation modulates the interaction of hnRNP I (zeige PTBP1 Proteine) and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase (zeige NOS2 Proteine) mRNA
decreased surface alpha2beta1 results from decreased Itga2 (zeige ITGA2 Proteine) pre-mRNA splicing regulated by hnRNP L and depends on CA repeat length at a specific site in intron 1
iNOS mRNA degradation is promoted upon binding of hnRNPI and hnRNPL to a destabilizing region within its 3'-UTR
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
, heterogeneous nuclear ribonucleoprotein L
, Heterogeneous nuclear ribonucleoprotein L
, heterogenous nuclear ribonucleoprotein L