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HNRNPK belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Zusätzlich bieten wir Ihnen Heterogeneous Nuclear Ribonucleoprotein K Kits (30) und Heterogeneous Nuclear Ribonucleoprotein K Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 165 products:
Mouse (Murine) Monoclonal HNRNPK Primary Antibody für ChIP, ELISA - ABIN108575
Matunis, Michael, Dreyfuss: Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. in Molecular and cellular biology 1992
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Mouse (Murine) Monoclonal HNRNPK Primary Antibody für ChIP, ELISA - ABIN108576
Blanchette, Fuentes Medel, Gardner: Cell-type-specific and developmental regulation of heterogeneous nuclear ribonucleoprotein K mRNA in the rat nervous system. in Gene expression patterns : GEP 2006
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Human Polyclonal HNRNPK Primary Antibody für IF, WB - ABIN516590
Proepper, Steinestel, Schmeisser, Heinrich, Steinestel, Bockmann, Liebau, Boeckers: Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology. in PLoS ONE 2011
Chicken Monoclonal HNRNPK Primary Antibody für IHC (p), WB - ABIN2474083
Bomsztyk, Van Seuningen, Suzuki, Denisenko, Ostrowski: Diverse molecular interactions of the hnRNP K protein. in FEBS letters 1997
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we discovered that hnRNPK plays an important role in bladder cancer, suggesting that it is a potential prognostic marker and a promising target for treating bladder cancer.
The hnRNPK positively regulates the level of prostate tumor overexpressed 1 (zeige PTOV1 Antikörper)-antisense 1 which harbors five binding sites for miR (zeige MLXIP Antikörper)-1207-5p. The knockdown of hnRNPK or PTOV1 (zeige PTOV1 Antikörper)-AS1 (zeige PTGDR Antikörper) increased the enrichment of heme oxygenase-1 (zeige HMOX1 Antikörper) mRNA in miR (zeige MLXIP Antikörper)-1207-5p-mediated miRNA-induced silencing complex and thus suppressed the expression of heme oxygenase-1 (zeige HMOX1 Antikörper).
High HNRNPK expression is associated with pancreatic cancer.
Down-regulation of DAB2IP (zeige DAB2IP Antikörper) correlated negatively with hnRNPK and MMP2 (zeige MMP2 Antikörper) expressions in CRC (zeige CALR Antikörper) tissues. In conclusion, our study elucidates a novel mechanism of the DAB2IP (zeige DAB2IP Antikörper)/hnRNPK/MMP2 (zeige MMP2 Antikörper) axis in the regulation of CRC (zeige CALR Antikörper) invasion and metastasis, which may be a potential therapeutic target.
Tumor cells bearing a p53 (zeige TP53 Antikörper) mutation showed increased damage levels and delayed repair. Knockdown of hnRNPK applied simultaneously with irradiation reduced colony-forming ability and survival of tumor cells. Taken together, our data shows that hnRNPK is a relevant modifier of DNA damage repair and tumor cell survival. We therefore recommend further studies to evaluate the potential of hnRNPK as a drug target for improvement
Data suggest that hnRNPK plays role in heat shock response of cells by regulating HSF1; hnRNPK inhibits HSF1 activity, resulting in reduced expression of HSP27 and HSP70 mRNAs; hnRNPK also down-regulates binding of HSF1 to heat shock response element. (hnRNPK = heterogeneous-nuclear ribonucleoprotein K; HSF1 = heat shock transcription factor 1; HSP = heat-shock protein)
KRAS-mutant colorectal carcinoma shows intrinsic radioresistance along with rapid upregulation of hnRNP K in response to ionizing radiation that can effectively be targeted by MEK (zeige MAP2K1 Antikörper) inhibition.
Nujiangexathone A, a novel compound from Garcinia nujiangensis, down-regulates hnRNPK levels in cervical tumor cells, inducing cell cycle arrest.
Our study also suggests that loss of function variants in HNRNPK should be considered as a molecular basis for patients with Kabuki-like syndrome
these findings support a critical role for hnRNP K in the regulation of autophagy in drug-resistant leukemia cells, and this RNP (zeige RNPC3 Antikörper) is therefore a potential target of clinical drug-resistance treatment.
A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo has been described.
a previously unidentified function of phosphorylation at this phylogenetically conserved site and implicates hnRNPK as an intracellular molecular target of ERK (zeige MAPK1 Antikörper)-mediated signaling in axon outgrowth.
hnRNP K is essential for successful optic axon regeneration via a novel post-transcriptional regulatory pathway.
A crucial role is reported for hnrpk in axon development in Xenoops laevis.
This is the first study revealing the presence of a parallel increase in expressions of FTO (zeige FTO Antikörper) and HNRNPK proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK in FTO (zeige FTO Antikörper)-associated transformations.
hnRNPK recruits PCGF3 (zeige PCGF3 Antikörper)/5-PRC1 (zeige PRC1 Antikörper) to the Xist RNA B-repeat to establish polycomb (zeige CBX2 Antikörper)-mediated chromosomal silencing.
the beneficial actions of insulin (zeige INS Antikörper) in diabetic nephropathy appear to be mediated, in part, by suppressing renal Nrf2 (zeige NFE2L2 Antikörper) and Agt (zeige AGXT Antikörper) gene transcription and preventing Nrf2 (zeige NFE2L2 Antikörper) stimulation of Agt (zeige AGXT Antikörper) expression via hnRNP F (zeige HNRNPF Antikörper)/K.
the cytoplasmic hnRNPK interacts with GSK3beta and regulates its function.
Data implicate hnRNPK in the development of hematological disorders and suggest hnRNPK acts as a tumor suppressor.
These findings functionally integrate K17 (zeige KRT17 Antikörper), hnRNP K, and gene expression along with RSK (zeige RPS6KA1 Antikörper) and CXCR3 (zeige CXCR3 Antikörper) signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis
Nova haploinsufficient mice had spontaneous epilepsy
HnRNP K-3' UTR (zeige UTS2R Antikörper) complex inhibits TAK1 (zeige NR2C2 Antikörper) mRNA translation.
hnRNP-K regulates extracellular matrix, cell motility, and angiogenesis pathways. Involvement of the selected genes (Cck (zeige CCK Antikörper), Mmp-3 (zeige MMP3 Antikörper), Ptgs2 (zeige PTGS2 Antikörper), and Ctgf (zeige CTGF Antikörper)) and pathways was validated by gene-specific expression analysis
HNRNPK affects production of the essential NEAT1_2 isoform by negatively regulating its 3'-end polyadenylation by arresting CFIm (zeige CPSF6 Antikörper) complex binding near NEAT1_1's alternative polyadenylation site.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference\; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.
dC-stretch binding protein
, transformation upregulated nuclear protein
, dC stretch-binding protein
, hnRNP K
, heterogeneous nuclear ribonucleoprotein K
, heterogeneous nuclear ribonucleoprotein k
, hnRNP-K protein
, heterogeneous nuclear ribonucleoprotein K-like