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This protein belongs to the basic helix-loop-helix family of transcription factors. Zusätzlich bieten wir Ihnen HES1 Kits (16) und HES1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 164 products:
Cow (Bovine) Polyclonal HES1 Primary Antibody für IF, IP - ABIN2779597
Hoebeke, De Smedt, Van de Walle, Reynvoet, De Smet, Plum, Leclercq: Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells. in Blood 2006
Show all 12 Pubmed References
Human Monoclonal HES1 Primary Antibody für ChIP, ICC - ABIN4317125
Wang, Wei, Han, Sato, Ghanbari-Azarnier, Whetstone, Poon, Hu, Zheng, Zhang, Wang, Wunder, Alman: Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. in Cancer research 2012
Show all 5 Pubmed References
Mouse (Murine) Polyclonal HES1 Primary Antibody für IF (p), IHC (p) - ABIN682393
Long, Qiu, Liu, Fei, Feng, Wang, Zhong, Yi, Liu, Zhang, Han: Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells. in Neuroscience 2012
Show all 3 Pubmed References
Human Polyclonal HES1 Primary Antibody für ICC, IF - ABIN440957
Kang, Yang, Xiao, Guo, Guo, Yan, Qi, Wang, Ryffel, Li, Deng: Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesisviathe Interleukin-33-MicroRNA-34a-Notch1 Pathway. in Frontiers in immunology 1970
In the present study, the authors reported the first observation of Hes1 oscillatory expression in human neural progenitor /stem cells, with an approximately 1.5 hour periodicity and a Hes1 protein half-life of about 17 (17.6 +/- 0.2) minutes. Human cytomegalovirus infection disrupts the Hes1 rhythm and down-regulates its expression.
A three-molecule score based on the expression of Notch (zeige NOTCH1 Antikörper) pathway molecules: Jagged1 (zeige JAG1 Antikörper), intracellular Notch1 (zeige NOTCH1 Antikörper) (ICN1) and Hes1 (JIH score) to assess prognostic value in non-metastasis clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC).
we demonstrate for the first time an essential role of HPV oncoprotein E6 that selectively overexpresses in CaCxSLCs and participates in maintenance of stem cell phenotype and stemness through upregulation of Hes1 while preponderance of E7 leads to differentiation.
IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase (zeige MUL1 Antikörper), followed by proteasomal degradation of Hes1.
Notch (zeige NOTCH1 Antikörper) signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch (zeige NOTCH1 Antikörper).
The phenotype was rescued by ectopic expression of miRNA182-5p in Delta182 cells. A bioinformatic analysis and Hes1 modulation data suggested that Hes1 could be a putative target of miRNA182-5p. A reciprocal relationship between miRNA182-5p and Hes1 was seen in the context of TK inhibition
These results suggest that HES1 promotes extracellular matrix protein expression and inhibits proliferative and migratory functions in the trabecular meshwork cells under oxidative stress, thereby providing a novel pathogenic mechanism underlying and a potential therapeutic target to primary open-angle glaucoma
Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target.
Low Hes1 expression is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.
GPR146 (zeige GPR146 Antikörper) has an antiviral role in fighting against viral infection, although the GPR146 (zeige GPR146 Antikörper)-mediated protection is eliminated by IRF3 (zeige IRF3 Antikörper)/HES1-signalling.
These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E (zeige APOE Antikörper)(-/-) mice, in which downregulation of hes1 and hes5 (zeige HES5 Antikörper) is involved.
Although Hes5 (zeige HES5 Antikörper)-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5 (zeige HES5 Antikörper)-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis (zeige CISH Antikörper)-regulatory elements that regulate endogenous Hes5 (zeige HES5 Antikörper) in the mouse lens and retina.
there is a link between Dmrta2 (zeige DMRTA2 Antikörper) modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development
Hes-1 expression is maintained in neural progenitor territory throughout mouse neocortical development, a simple shift from Notch (zeige NOTCH1 Antikörper)-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells.
inhibition of PTEN by Notch1 (zeige NOTCH1 Antikörper)/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy
this paper shows the critical role of the Notch1 (zeige NOTCH1 Antikörper)-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation
results suggest that SCF (zeige KITLG Antikörper)(FBXL14 (zeige FBXL14 Antikörper)) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process
that HIF-1alpha (zeige HIF1A Antikörper) but not HIF-2alpha (zeige EPAS1 Antikörper) is able to interact with either GA-binding protein alpha or GA-binding protein beta1
study identified nucleolar complex protein 3 homolog(FAD24 (zeige NOC3L Antikörper)) as a novel downstream target of transcription factor HES1 during adipogenesis
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
class B basic helix-loop-helix protein 39
, hairy homolog
, hairy-like protein
, transcription factor HES-1
, Hairy and enhancer of split 1-A
, Protein hairy-1
, transcription factor HES-1-A
, hairy and enhancer of split 1
, LOW QUALITY PROTEIN: transcription factor HES-1