Hepatic Leukemia Factor Proteine (HLF)

HLF encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. Zusätzlich bieten wir Ihnen HLF Antikörper (42) und HLF Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HLF 217082 Q8BW74
HLF 3131 Q16534
HLF 29452 Q9JHS1
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 15 bis 19 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 2 bis 3 Tage

HLF Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
Rat (Rattus)

Weitere Proteine zu Hepatic Leukemia Factor (HLF) Interaktionspartnern

Mouse (Murine) Hepatic Leukemia Factor (HLF) Interaktionspartner

  1. Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.

  2. Data show that Tet1 (zeige TET1 Proteine) modulates HIF-2alpha (zeige EPAS1 Proteine) and HIF-1alpha (zeige HIF1A Proteine) through different mechanisms.

  3. intestine HIF-2alpha (zeige EPAS1 Proteine) regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (zeige Neu3 Proteine), the gene encoding neuraminidase 3 (zeige Neu3 Proteine). These results suggest that intestinal HIF-2alpha (zeige EPAS1 Proteine) could be a viable target for hepatic steatosis therapy

  4. endothelial EPAS1 (zeige EPAS1 Proteine) has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II

  5. findings indicate that HIF-2alpha (zeige EPAS1 Proteine) increases cancer cell growth by up-regulating YAP1 (zeige YAP1 Proteine) activity

  6. Chronic activity of HIF2 (zeige EPAS1 Proteine) in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.

  7. this study shows that HIF-2alpha (zeige EPAS1 Proteine) acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha (zeige EPAS1 Proteine) and susceptibility to infection

  8. in neurons HIF-1 (zeige HIF1A Proteine) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (zeige HIF1A Proteine)/Hif2a (zeige EPAS1 Proteine)-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke

  9. HIF-2alpha (zeige EPAS1 Proteine) is a novel regulator of neutrophil recruitment to colon tumors.

  10. AQP1 (zeige AQP1 Proteine) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha (zeige EPAS1 Proteine).

Human Hepatic Leukemia Factor (HLF) Interaktionspartner

  1. Poly (ADP-ribose) polymerase (zeige PARP1 Proteine) inhibitors selectively induce cytotoxicity in TCF3 (zeige TCF3 Proteine)-HLF (zeige EPAS1 Proteine)-positive leukemic cells.

  2. HLF-mediated miR-132 directly suppresses TTK expression, thus exerting inhibitory effects on cancer cell proliferation, metastasis and radioresistance.

  3. Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3 (zeige TCF3 Proteine)-HLF (zeige EPAS1 Proteine) ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids.

  4. ectopic expression of HLF (zeige EPAS1 Proteine), an established transcription factor that cycles with circadian rhythms, can recapitulate many features associated with circadian-dependent physiological variation.

  5. both Lmo2 (zeige LMO2 Proteine) and Bcl-2 (zeige BCL2 Proteine) are required for the action of E2A (zeige TCF3 Proteine)-HLF (zeige EPAS1 Proteine) in leukemogenesis

  6. E2A (zeige TCF3 Proteine)-HLF (zeige EPAS1 Proteine) promotes cell survival of t(17;19)- acute lymphoblastic leukemia cells by aberrantly up-regulating LMO2 (zeige LMO2 Proteine) expression

  7. Evidence pertaining to leukemogenesis by the well-characterized oncogenic fusion protein E2A (zeige TCF3 Proteine)-HLF (zeige EPAS1 Proteine) is reviewed and its mechanistic implications are considered.

  8. E2A-HLF induces annexin II by substituting for cytokines that activate downstream pathways of Ras

  9. The E2A (zeige TCF3 Proteine)-HLF (zeige EPAS1 Proteine)-mediated over-expression of ABCB1 (zeige ABCB1 Proteine) may play a role in the clinical phenotype of ALLs with a t(17;19), suggesting pharmacologic modulation of ABCB1 (zeige ABCB1 Proteine) activity as a rational therapeutic strategy for this chemotherapy resistant subtype of ALL.

  10. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: E2A (zeige TCF3 Proteine)/PBX1 (zeige PBX1 Proteine) and E2A (zeige TCF3 Proteine)/HLF (zeige EPAS1 Proteine).

HLF Protein Überblick

Protein Überblick

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Genbezeichner und Symbole assoziert mit Hepatic Leukemia Factor Proteine (HLF)

  • HLF, PAR bZIP transcription factor (HLF)
  • hepatic leukemia factor (Hlf)
  • hepatic leukemia factor a (hlfa)
  • Hepatic leukemia factor (Bm1_18395)
  • Hepatic leukemia factor (hlf)
  • endothelial PAS domain protein 1 (Epas1)
  • HLF, PAR bZIP transcription factor (Hlf)
  • bHLHe73 Protein
  • DKFZp469P0721 Protein
  • E230015K02Rik Protein
  • HIF-2alpha Protein
  • Hif2a Protein
  • Hlf Protein
  • HLF1 Protein
  • HRF Protein
  • MOP2 Protein
  • zgc:153035 Protein

Bezeichner auf Proteinebene für Hepatic Leukemia Factor Proteine (HLF)

hepatic leukemia factor , hepatic leukemia factor 1 , zhlf1 , Hepatic leukemia factor , EPAS-1 , HIF-1-alpha-like factor , HIF-2-alpha , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HIF2-alpha , HLF (HIF1alpha-like factor) , Hif like protein , endothelial PAS domain-containing protein 1 , hypoxia inducible transcription factor 2alpha , hypoxia-inducible factor 2-alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , hypoxia-inducible factor 2 alpha

706623 Macaca mulatta
516069 Bos taurus
217082 Mus musculus
100192429 Ovis aries
100171535 Pongo abelii
593063 Strongylocentrotus purpuratus
417395 Gallus gallus
455140 Pan troglodytes
3131 Homo sapiens
768192 Danio rerio
6098588 Brugia malayi
100380463 Salmo salar
13819 Mus musculus
29452 Rattus norvegicus
100724740 Cavia porcellus
690286 Rattus norvegicus
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